公开(公告)号：US20230136466A1

公开(公告)日：2023-05-04

申请号：US17944006

申请日：2022-09-13

申请人： FENFEI LENG ,  EDDY ALFONSO ,  ZIFANG DENG

发明人： FENFEI LENG ,  EDDY ALFONSO ,  ZIFANG DENG

IPC分类号： A61K31/7048 ,  A61P31/04 ,  A61K31/7076 ,  A61K31/475 ,  A61K31/196 ,  A61K31/5377 ,  A61K31/404 ,  A61K31/427 ,  A61K31/519 ,  A61K31/429 ,  A61K31/4196 ,  A61K31/433 ,  A61K31/513 ,  A61K31/366 ,  A61K31/443 ,  A61K31/498 ,  A61K31/496 ,  A61K31/24 ,  A61K31/185 ,  A61K31/4155 ,  A61K31/4184 ,  A61K31/381 ,  A61K31/352 ,  A61K31/52 ,  A61K31/192 ,  A61K31/473

摘要： The subject invention provides fluorophore-quencher nucleic acid molecules comprising relaxed or supercoiled DNA molecules, and their use in rapid and efficient high-throughput screening (HTS) assays to screen and identify compounds that inhibit DNA gyrases. These compounds can be used as antibiotics for treating bacterial infections, especially, multidrug resistant bacterial infections.