公开(公告)号：US20230242529A1

公开(公告)日：2023-08-03

申请号：US18170022

申请日：2023-02-16

申请人： FIMECS, Inc.

发明人： Yusuke TOMINARI ,  Yoshihide TOMATA ,  Kanae GAMO ,  Naomi KITAMOTO

IPC分类号： C07D471/04 ,  C07D209/08 ,  C07D209/42 ,  C07D231/14 ,  C07D231/56 ,  C07D235/08 ,  C07D403/06 ,  C07D403/12 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D487/08 ,  C07D495/14

CPC分类号： C07D471/04 ,  C07D209/08 ,  C07D209/42 ,  C07D231/14 ,  C07D231/56 ,  C07D235/08 ,  C07D403/06 ,  C07D403/12 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D487/08 ,  C07D495/14

摘要： One of the purposes of the present invention is to provide a heterocyclic derivative that has an IAP (particularly XIAP) binding (inhibiting) activity. Another of the purposes of the present invention is to provide a heterocyclic derivative that has an IAP (particularly XIAP) binding (inhibiting) activity and exhibits a protein degradation induction activity. The present invention provides a compound represented by formula (I) (the symbols in the formula are as defined in the present Description) and salts thereof.

公开(公告)号：US20210179614A1

公开(公告)日：2021-06-17

申请号：US17263580

申请日：2019-07-31

申请人： FIMECS, INC.

发明人： Yusuke TOMINARI ,  Yoshihide TOMATA ,  Kanae GAMO ,  Naomi KITAMOTO

IPC分类号： C07D471/04 ,  C07D209/42 ,  C07D231/14 ,  C07D231/56 ,  C07D235/08 ,  C07D403/06 ,  C07D413/14 ,  C07D403/12 ,  C07D487/04 ,  C07D487/08 ,  C07D209/08 ,  C07D495/14 ,  C07D417/14

摘要： One of the purposes of the present invention is to provide a heterocyclic derivative that has an IAP (particularly XIAP) binding (inhibiting) activity. Another of the purposes of the present invention is to provide a heterocyclic derivative that has an IAP (particularly XIAP) binding (inhibiting) activity and exhibits a protein degradation induction activity. The present invention provides a compound represented by formula (I) (the symbols in the formula are as defined in the present Description) and salts thereof.

公开(公告)号：US20220402935A1

公开(公告)日：2022-12-22

申请号：US17630203

申请日：2020-07-31

申请人： FIMECS, INC.

发明人： Yusuke TOMINARI ,  Yoshihide TOMATA ,  Kanae GAMO ,  Naomi KITAMOTO

IPC分类号： C07D495/04 ,  C07D519/00 ,  A61P35/00 ,  A61P11/00

摘要： It is to provide a novel heterocyclic compound which has the effect of inducing degradation of interleukin-1 receptor-associated kinase-M (IRAK-M) protein and is expected to be useful for the prevention/treatment of cancer, fibrosis, infectious diseases, etc. The present invention provides a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof.