公开(公告)号：US20210332137A1

公开(公告)日：2021-10-28

申请号：US17224865

申请日：2021-04-07

申请人： Five Prime Therapeutics, Inc.

发明人： Sandeep P. INAMDAR ,  Helen L. COLLINS ,  Hong XIANG ,  Xiang ZHANG ,  Neyssa MARINA

IPC分类号： C07K16/28 ,  A61P35/00

摘要： The present disclosure provides methods of administering antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4 to a subject in need thereof, for example, a cancer patient, in combination with a PD-1/PD-L1 antagonist, such as an anti-PD-1 antibody.

公开(公告)号：US20210340214A1

公开(公告)日：2021-11-04

申请号：US17271792

申请日：2019-08-28

申请人： FIVE PRIME THERAPEUTICS, INC.

发明人： Sandeep P. INAMDAR ,  Kristen PIERCE ,  Hong XIANG ,  Susannah D. BARBEE

IPC分类号： C07K14/705 ,  A61P35/00 ,  A61K9/00 ,  A61K31/7012 ,  C07K16/18

摘要： The present disclosure provides methods of administering fusion proteins comprising the extracellular domain of human cluster of differentiation 80 (CD80) and the fragment crystallizable (Fc) domain of human immunoglobulin G 1 (IgG1) to a subject in need thereof, for example, a cancer patient.

公开(公告)号：US20230023174A1

公开(公告)日：2023-01-26

申请号：US17773800

申请日：2020-11-11

申请人： FIVE PRIME THERAPEUTICS, INC.

发明人： Hong XIANG ,  Siddhartha MITRA

IPC分类号： C07K14/705 ,  A61P35/00

摘要： The present disclosure provides methods of administering fusion proteins comprising the extracellular domain of human cluster of differentiation 80 (CD80) and the fragment crystallizable (Fc) domain of human immunoglobulin G1 (IgG1) to a subject in need thereof, for example, a cancer patient.

公开(公告)号：US20210070862A1

公开(公告)日：2021-03-11

申请号：US16997581

申请日：2020-08-19

申请人： Five Prime Therapeutics, Inc.

发明人： Sandeep P. INAMDAR ,  Helen L. COLLINS ,  Xiang ZHANG ,  Hong XIANG

IPC分类号： C07K16/28 ,  A61P35/00

摘要： The present disclosure provides methods of administering antibodies and antigen-binding fragments thereof that specifically bid to human B7-H4 to a subject in need thereof, for example, a cancer patient.

公开(公告)号：US20230382972A9

公开(公告)日：2023-11-30

申请号：US17773800

申请日：2020-11-04

申请人： FIVE PRIME THERAPEUTICS, INC.

发明人： Hong XIANG ,  Siddhartha MITRA

IPC分类号： C07K14/705 ,  A61P35/00

CPC分类号： C07K14/70532 ,  A61P35/00 ,  A61K2039/505

摘要： The present disclosure provides methods of administering fusion proteins comprising the extracellular domain of human cluster of differentiation 80 (CD80) and the fragment crystallizable (Fc) domain of human immunoglobulin G1 (IgG1) to a subject in need thereof, for example, a cancer patient.