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公开(公告)号：US11939383B2
公开(公告)日：2024-03-26
申请号：US17006670
申请日：2020-08-28
发明人： Charles Kaplan , Alessandro Palumbo , Kathy Miller , Hangil Park , Nerissa Mendoza , Majid Ghoddusi
IPC分类号： C07K16/18 , A61K39/00 , A61K39/395 , A61P35/00 , C07K16/28 , G01N33/574
CPC分类号： C07K16/2827 , G01N33/57492 , C07K2317/56 , C07K2317/565 , G01N2333/70532
摘要： The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4. The anti-B7-H4 antibodies or antigen-binding fragments thereof are useful, for example in detecting B7-H4. Immunohistochemistry (IHC) can be used to detect B7-H4. The present disclosure also provides methods for treating cancer wherein increased B7-H4 has been detected, by administering a therapeutic anti-B7-H4 antibody or antigen-binding fragment thereof.
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公开(公告)号：US20240043542A1
公开(公告)日：2024-02-08
申请号：US18484986
申请日：2023-10-11
发明人： Charles Kaplan , Derrick Houser , Luis Borges , Gloria Brattich , David Bellovin , Felicia Kemp , Majid Ghoddusi , Nels P. Nielson , Kathy Miller , Maike Schmidt
IPC分类号： C07K16/28 , A61P35/00 , G01N33/574
CPC分类号： C07K16/2827 , C07K16/2818 , A61P35/00 , G01N33/57492 , A61K2039/505
摘要： The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4 (and optionally cynomolgus monkey, mouse, and/or rat B7-H4) and compositions comprising such antibodies or antigen-binding fragments thereof. In a specific aspect, the antibodies or antigen-binding fragments thereof that specifically bind to human B7-H4 increase T cell proliferation, increase interferon-gamma production, and/or deplete B7-H4 expressing cells via ADCC activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody or antigen-binding fragment thereof that specifically binds to human B7-H4.
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公开(公告)号：US11789010B2
公开(公告)日：2023-10-17
申请号：US16608911
申请日：2018-04-27
CPC分类号： G01N33/5011 , G01N15/10 , G01N2015/0065 , G01N2015/1006 , G01N2333/70532 , G01N2800/52
摘要： This application relates to use of CD80 (B7-1) extracellular domain (ECD) polypeptides and CD80-ECD fusion molecules and their use in methods of increasing the number of central memory T cells or for treatment for cancer or for use in cancer vaccine compositions.
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4.发明公开公开(公告)号：US20230192870A1
公开(公告)日：2023-06-22
申请号：US17812592
申请日：2022-07-14
发明人： Katherine E. Lewis , Serena Kimi Perna , Michael Carleton , Ke Xu , Penny Phillips , Dimple Pandya , Brian Wong , Julie Hambleton , Robert Sikorski , Emma Masteller , Kevin Hestir , David Bellovin , Janine Powers , Ernestine Lee
IPC分类号： C07K16/28 , A61K47/69 , A61K47/64 , A61P35/00 , A61K31/337 , A61K31/513 , A61K31/7068 , A61K39/395 , C12Q1/6886
CPC分类号： C07K16/2866 , A61K47/6929 , A61K47/643 , A61P35/00 , A61K31/337 , A61K31/513 , A61K31/7068 , A61K39/3955 , C07K16/2818 , C12Q1/6886 , A61K2039/507
摘要： The present invention relates to methods of treating pancreatic cancer with particular dosage regimes of antibodies that bind colony stimulating factor 1 receptor (CSF1R) (e.g. cabiralizumab) in combination with antibodies that bind programmed cell death 1 (PD-1) (e.g. nivolumab).
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公开(公告)号：US20230013293A1
公开(公告)日：2023-01-19
申请号：US17685056
申请日：2022-03-02
发明人： Charles Kaplan , Derrick Houser , Luis Borges , Gloria Brattich , David Bellovin , Felicia Kemp , Majid Ghoddusi , Nels P. Nielson , Kathy Miller , Maike Schmidt
IPC分类号： C07K16/28 , A61P35/00 , G01N33/574
摘要： The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4 (and optionally cynomolgus monkey, mouse, and/or rat B7-H4) and compositions comprising such antibodies or antigen-binding fragments thereof. In a specific aspect, the antibodies or antigen-binding fragments thereof that specifically bind to human B7-H4 increase T cell proliferation, increase interferon-gamma production, and/or deplete B7-H4 expressing cells via ADCC activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody or antigen-binding fragment thereof that specifically binds to human B7-H4.
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公开(公告)号：US20220348657A1
公开(公告)日：2022-11-03
申请号：US17604505
申请日：2020-04-17
发明人： Luis BORGES , Artur KARASYOV , Zheng MENG , Shawn RUSSELL , Nathan SALLEE , Hongbing ZHANG , Aileen ZHOU
IPC分类号： C07K16/28 , C07K14/705 , G01N33/554
摘要： Provided herein are components (e.g., cells and soluble proteins), systems, and methods for assessing the biological activity of soluble proteins comprising an Fc domain and a CD28-binding domain (e.g., CD80 extracellular domain Fc fusion proteins).
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公开(公告)号：US20220168416A1
公开(公告)日：2022-06-02
申请号：US17554423
申请日：2021-12-17
IPC分类号： A61K39/395 , C07K16/28 , A61K33/243 , A61K31/337 , A61K31/513 , A61K45/06
摘要： The present invention provides antibodies that bind FGFR2IIIb, wherein the antibodies are afucosylated. The present invention provides compositions comprising antibodies that bind FGFR2IIIb, wherein at least 95% of the antibodies in the composition are afucosylated. In some embodiments, methods of treating cancer comprising administering afucosylated anti-FGFR2IIIb antibodies are provided.
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公开(公告)号：US11306150B2
公开(公告)日：2022-04-19
申请号：US16476814
申请日：2018-01-10
摘要： Methods of identifying and using PSGL-1 antagonists are provided. Such methods include, but are not limited to, methods of treating cancer. PSGL-1 antagonists include, but are not limited to, antibodies that bind PSGL-1 and antibodies that bind VISTA, wherein the antibodies inhibit PSGL-1 binding to VISTA, e.g., at acidic pH (e.g., pH 6.0), as well as PSGL-1 and VISTA extracellular domain polypeptides.
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公开(公告)号：US20210332137A1
公开(公告)日：2021-10-28
申请号：US17224865
申请日：2021-04-07
发明人： Sandeep P. INAMDAR , Helen L. COLLINS , Hong XIANG , Xiang ZHANG , Neyssa MARINA
摘要： The present disclosure provides methods of administering antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4 to a subject in need thereof, for example, a cancer patient, in combination with a PD-1/PD-L1 antagonist, such as an anti-PD-1 antibody.
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10.发明授权公开(公告)号：US10975153B2
公开(公告)日：2021-04-13
申请号：US15319143
申请日：2015-06-18
发明人： Julie Hambleton , Emma Masteller , James Zanghi , Robert Sikorski , Hong Xiang
IPC分类号： C07K16/28 , A61K39/00 , A61K39/395
摘要： Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided. Such methods include, but are not limited to, methods of treating rheumatoid arthritis.
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