公开(公告)号：US10940188B2

公开(公告)日：2021-03-09

申请号：US16779132

申请日：2020-01-31

申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services ,  THE JOHNS HOPKINS UNIVERSITY

发明人： Hengli Tang ,  Emily M. Lee ,  Yichen Cheng ,  Yi Zhou ,  Wei Zheng ,  Ruili Huang ,  Miao Xu ,  Wenwei Huang ,  Menghang Xia ,  Hongjun Song ,  Guo-Li Ming ,  Zhexing Wen

IPC分类号： A61K38/55 ,  A61K31/24 ,  A61K31/609 ,  A61K38/43 ,  A61K45/06 ,  C07C239/02 ,  C07C239/08 ,  A61K38/00

摘要： The present invention concerns the use of compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering a compound or class of compound disclosed herein, such as a niclosamide compound, an emricasan compound, a cyclin-dependent kinase inhibitor, a proteasome inhibitor, or a combination of two or more of the foregoing, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections.