公开(公告)号：US10940188B2

公开(公告)日：2021-03-09

申请号：US16779132

申请日：2020-01-31

申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services ,  THE JOHNS HOPKINS UNIVERSITY

发明人： Hengli Tang ,  Emily M. Lee ,  Yichen Cheng ,  Yi Zhou ,  Wei Zheng ,  Ruili Huang ,  Miao Xu ,  Wenwei Huang ,  Menghang Xia ,  Hongjun Song ,  Guo-Li Ming ,  Zhexing Wen

IPC分类号： A61K38/55 ,  A61K31/24 ,  A61K31/609 ,  A61K38/43 ,  A61K45/06 ,  C07C239/02 ,  C07C239/08 ,  A61K38/00

摘要： The present invention concerns the use of compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering a compound or class of compound disclosed herein, such as a niclosamide compound, an emricasan compound, a cyclin-dependent kinase inhibitor, a proteasome inhibitor, or a combination of two or more of the foregoing, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections.

公开(公告)号：US10555942B2

公开(公告)日：2020-02-11

申请号：US16156124

申请日：2018-10-10

申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  THE JOHNS HOPKINS UNIVERSITY ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Hengli Tang ,  Emily M. Lee ,  Anil Mathew Tharappel ,  Hongjun Song ,  Guo-Li Ming ,  Wei Zheng ,  Miao Xu ,  Shu Yang ,  Ruili Huang ,  Wenwei Huang ,  Khalida Shamim ,  Hao Li

IPC分类号： A61K31/4745 ,  A61K45/06 ,  A61P31/14

摘要： The present invention concerns the use of emetine compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering an emetine compound such as emetine or cephaeline, or a combination of two or more emetine compounds, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections.

公开(公告)号：US11207315B2

公开(公告)日：2021-12-28

申请号：US16718343

申请日：2019-12-18

申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  THE JOHNS HOPKINS UNIVERSITY ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Hengli Tang ,  Emily M. Lee ,  Anil Mathew Tharappel ,  Hongjun Song ,  Guo-Li Ming ,  Wei Zheng ,  Miao Xu ,  Shu Yang ,  Ruili Huang ,  Wenwei Huang ,  Khalida Shamim ,  Hao Li

IPC分类号： A61K31/4745 ,  A61K45/06 ,  A61P31/14

摘要： The present invention concerns the use of emetine compounds for the treatment or prevention of Flavivirus infections, such as dengue virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus infection, by administering an emetine compound such as emetine or cephaeline, or a combination of two or more emetine compounds, to a subject in need thereof; methods for inhibiting Flavivirus infections such as dengue virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such dengue virus infections.

公开(公告)号：US11471443B2

公开(公告)日：2022-10-18

申请号：US16861281

申请日：2020-04-29

申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： Hengli Tang ,  Emily M. Lee ,  Wei Zheng ,  Ruili Huang ,  Miao Xu ,  Wenwei Huang ,  Khalida Shamim ,  Guoli Ming ,  Hongjun Song

IPC分类号： A61K31/4162 ,  A61P31/14 ,  A61K31/4184 ,  A61K31/245 ,  A61K31/433 ,  A61K31/4535 ,  A61K31/517 ,  A61K31/4741 ,  A61K31/554 ,  A61K31/422 ,  A61K31/4709 ,  A61K31/336 ,  A61K31/427 ,  A61K31/506 ,  A61K31/519 ,  A61K31/352 ,  A61K31/165

摘要： The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.

公开(公告)号：US11878004B2

公开(公告)日：2024-01-23

申请号：US17809353

申请日：2022-06-28

申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： Hengli Tang ,  Emily M. Lee ,  Wei Zheng ,  Ruili Huang ,  Miao Xu ,  Wenwei Huang ,  Khalida Shamim ,  Guoli Ming ,  Hongjun Song

IPC分类号： A61K31/4162 ,  A61P31/14 ,  A61K31/4184 ,  A61K31/245 ,  A61K31/433 ,  A61K31/4535 ,  A61K31/517 ,  A61K31/4741 ,  A61K31/554 ,  A61K31/422 ,  A61K31/4709 ,  A61K31/336 ,  A61K31/427 ,  A61K31/506 ,  A61K31/519 ,  A61K31/352 ,  A61K31/165

CPC分类号： A61K31/4184 ,  A61K31/165 ,  A61K31/245 ,  A61K31/336 ,  A61K31/352 ,  A61K31/4162 ,  A61K31/422 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4535 ,  A61K31/4709 ,  A61K31/4741 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/554 ,  A61P31/14

摘要： The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.

公开(公告)号：US11779570B2

公开(公告)日：2023-10-10

申请号：US17809345

申请日：2022-06-28

申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： Hengli Tang ,  Emily M. Lee ,  Wei Zheng ,  Ruili Huang ,  Miao Xu ,  Wenwei Huang ,  Khalida Shamim ,  Guoli Ming ,  Hongjun Song

IPC分类号： A61K31/4162 ,  A61P31/14 ,  A61K31/4184 ,  A61K31/245 ,  A61K31/433 ,  A61K31/4535 ,  A61K31/517 ,  A61K31/4741 ,  A61K31/554 ,  A61K31/422 ,  A61K31/4709 ,  A61K31/336 ,  A61K31/427 ,  A61K31/506 ,  A61K31/519 ,  A61K31/352 ,  A61K31/165

CPC分类号： A61K31/4184 ,  A61K31/165 ,  A61K31/245 ,  A61K31/336 ,  A61K31/352 ,  A61K31/4162 ,  A61K31/422 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4535 ,  A61K31/4709 ,  A61K31/4741 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/554 ,  A61P31/14

摘要： The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.

公开(公告)号：US11903929B2

公开(公告)日：2024-02-20

申请号：US17809327

申请日：2022-06-28

申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： Hengli Tang ,  Emily M. Lee ,  Wei Zheng ,  Ruili Huang ,  Miao Xu ,  Wenwei Huang ,  Khalida Shamim ,  Guoli Ming ,  Hongjun Song

IPC分类号： A61K31/4162 ,  A61P31/14 ,  A61K31/4184 ,  A61K31/245 ,  A61K31/433 ,  A61K31/4535 ,  A61K31/517 ,  A61K31/4741 ,  A61K31/554 ,  A61K31/422 ,  A61K31/4709 ,  A61K31/336 ,  A61K31/427 ,  A61K31/506 ,  A61K31/519 ,  A61K31/352 ,  A61K31/165

CPC分类号： A61K31/4184 ,  A61K31/165 ,  A61K31/245 ,  A61K31/336 ,  A61K31/352 ,  A61K31/4162 ,  A61K31/422 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4535 ,  A61K31/4709 ,  A61K31/4741 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/554 ,  A61P31/14

摘要： The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.

公开(公告)号：US11850236B2

公开(公告)日：2023-12-26

申请号：US17809339

申请日：2022-06-28

申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： Hengli Tang ,  Emily M. Lee ,  Wei Zheng ,  Ruili Huang ,  Miao Xu ,  Wenwei Huang ,  Khalida Shamim ,  Guoli Ming ,  Hongjun Song

IPC分类号： A61K31/4162 ,  A61P31/14 ,  A61K31/4184 ,  A61K31/245 ,  A61K31/433 ,  A61K31/4535 ,  A61K31/517 ,  A61K31/4741 ,  A61K31/554 ,  A61K31/422 ,  A61K31/4709 ,  A61K31/336 ,  A61K31/427 ,  A61K31/506 ,  A61K31/519 ,  A61K31/352 ,  A61K31/165

CPC分类号： A61K31/4184 ,  A61K31/165 ,  A61K31/245 ,  A61K31/336 ,  A61K31/352 ,  A61K31/4162 ,  A61K31/422 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4535 ,  A61K31/4709 ,  A61K31/4741 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/554 ,  A61P31/14

摘要： The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.

公开(公告)号：US11096927B2

公开(公告)日：2021-08-24

申请号：US16721221

申请日：2019-12-19

申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： Hengli Tang ,  Emily M. Lee ,  Wei Zheng ,  Ruili Huang ,  Miao Xu ,  Wenwei Huang ,  Khalida Shamim ,  Guoli Ming ,  Hongjun Song

IPC分类号： A61P31/14 ,  A61K31/165 ,  A61K31/4184 ,  A61K31/245 ,  A61K31/433 ,  A61K31/4535 ,  A61K31/4162 ,  A61K31/517 ,  A61K31/4741 ,  A61K31/554 ,  A61K31/422 ,  A61K31/4709 ,  A61K31/336 ,  A61K31/427 ,  A61K31/506 ,  A61K31/519 ,  A61K31/352

摘要： The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.

公开(公告)号：US20140322704A1

公开(公告)日：2014-10-30

申请号：US14366467

申请日：2012-12-19

申请人： The Florida State University Research Foundation, Inc.

发明人： Hengli Tang ,  Xianfang Wu

IPC分类号： C12N7/00 ,  C12Q1/02 ,  C12N5/071

CPC分类号： C12N7/00 ,  C12N5/067 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/12 ,  C12N2501/16 ,  C12N2501/385 ,  C12N2501/415 ,  C12N2503/02 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2730/10151 ,  C12N2770/24251 ,  C12Q1/025 ,  C12Q1/18 ,  G01N33/5067 ,  G01N33/5767

摘要： The invention relates to the discovery that DHH derived from stem cells are permissive for infection by hepatitis viruses (HV), such as hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV) and hepatitis E virus (HEV). Included in the invention are HV-permissive DHHs and methods of making an HCV-permissive DHH derived from a stem cell. Also included is an HV culture system comprising at least one HV-permissive DHH. The HV-permissive DHH and HV culture system are useful for conducting HV life cycle analyses, diagnosing a subject as being infected with HV, genotyping and characterizing the HV of a subject infected with HV, detecting drug resistance of HV obtained from a subject infected with HV, screening for and identify modulators of HV infection, and monitoring the effect of a treatment of HV in a subject.

摘要翻译： 本发明涉及从干细胞衍生的DHH允许肝炎病毒（HV）如甲型肝炎病毒（HAV），乙型肝炎病毒（HBV），丙型肝炎病毒（HCV），丙型肝炎病毒（HCV） HDV）和戊型肝炎病毒（HEV）。 本发明中包括HV允许DHH和制备衍生自干细胞的HCV允许DHH的方法。 还包括HV培养系统，其包括至少一种HV允许DHH。 HV允许DHH和HV培养系统可用于进行HV生命周期分析，诊断被感染HV的受试者，对感染HV的受试者的HV进行基因分型和表征，检测从感染的受试者获得的HV的耐药性 HV，筛选和鉴定HV感染的调节剂，并监测受试者中HV的治疗效果。