-
公开(公告)号:US20230139737A1
公开(公告)日:2023-05-04
申请号:US17832214
申请日:2022-06-03
发明人: Rachel PERRET , Philip D. GREENBERG , Thomas M. SCHMITT , Aude G. CHAPUIS , Ingunn M. STROMNES , Tijana MARTINOV
摘要: The present disclosure provides compositions and methods for targeting a Ras antigen to, for example, treat or prevent cancer. Disclosed embodiments include binding proteins, such as a T cell receptor or a chimeric antigen receptor, that bind to a Ras antigen:HLA complex. Polynucleotides encoding such binding protein can introduced into a host cell, such as a T cell, and the cell can be used in immunotherapy for treating various cancers. Also provided are immunogenic polypeptides that can be useful to, for example, induce an immune response against a mutated Ras or to identify a binding protein that binds to a Ras antigen.