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1.发明公开公开(公告)号：US20240226257A9
公开(公告)日：2024-07-11
申请号：US18492705
申请日：2023-10-23
发明人： Justin J. Taylor , Denise Galloway , Paul Nghiem , David Koelle , Haroldo Rodriguez , Joseph Carter
IPC分类号： A61K39/00 , A61K45/06 , A61P35/00 , C07K16/28 , G01N33/533 , G01N33/574
CPC分类号： A61K39/001111 , A61K45/06 , A61P35/00 , C07K16/2809 , G01N33/533 , G01N33/57492 , A61K2039/53 , G01N2333/7051
摘要： Antibodies that bind the tumor (T) antigen of the Merkel cell polyomavirus are disclosed. The antibodies can be use used in cell-based immunotherapies, antibody-based therapies, diagnostics, and detection assays, among other uses. Related diagnostics are also described
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公开(公告)号：US20240150444A1
公开(公告)日：2024-05-09
申请号：US18548017
申请日：2022-02-25
CPC分类号： C07K16/1027 , A61P31/12 , A61K38/00 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： Antibodies that protect against respiratory viral infections including human parainfluenza viruses (HPIV), respiratory syncytial virus (RSV), and human metapneumovirus (HMPV) are described. Certain antibodies disclosed herein neutralize more than one virus (e.g., RSV and HMPV). The binding fragments of the antibodies can be engineered into numerous formats including those that provide simultaneous protection against multiple viruses.
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3.发明公开公开(公告)号：US20240094209A1
公开(公告)日：2024-03-21
申请号：US18509663
申请日：2023-11-15
发明人： Evan Greene , Greg Finak , Raphael Gottardo
IPC分类号： G01N33/574 , G16B5/00 , G16B25/10
CPC分类号： G01N33/5743 , G16B5/00 , G16B25/10
摘要： Disclosed herein are to markers, methods and systems for identifying cell populations, diagnosing, monitoring and treating cancer, including biomarkers predictive of response to immunotherapy treatment in Merkel cell carcinoma.
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公开(公告)号：US11932691B2
公开(公告)日：2024-03-19
申请号：US17157810
申请日：2021-01-25
IPC分类号： C07K16/28 , G01N33/574
CPC分类号： C07K16/2803 , G01N33/57492 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/622 , C07K2317/92 , G01N2333/70503
摘要： The present disclosure relates to anti-ROR1 binding proteins, including those that bind to a ROR1 or portion thereof such as an intracellular C terminal portion of a ROR1 protein, and the use of such binding proteins in immunohistochemical and diagnostic methods. Related kits and methods of using the binding proteins are also provided, as are methods of treatment of subjects having diseases or conditions determined to be candidates for such treatments by the binding proteins or methods of this disclosure.
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5.发明授权公开(公告)号：US11872195B2
公开(公告)日：2024-01-16
申请号：US16222942
申请日：2018-12-17
IPC分类号： A61K48/00 , C12N9/22 , C07K14/705 , C12N15/88 , A61K35/14
CPC分类号： A61K48/005 , C07K14/705 , C12N9/22 , C12N15/88 , A61K35/14
摘要： Compositions and methods that rapidly and selectively modify hematopoietic stem cells (or cells derived therefrom) to achieve therapeutic objectives by providing for transient expression of nucleic acids are described. The transient expression leads to permanent therapeutic changes in the modified cells, referred to herein as “hit and run” effects.
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公开(公告)号：US11821111B2
公开(公告)日：2023-11-21
申请号：US17097853
申请日：2020-11-13
发明人： Jesse Bloom , Allison Greaney , Andrea Loes , Adam S. Dingens
CPC分类号： C40B50/06 , C12N7/00 , C12N15/1065 , C12N2760/16021
摘要： Methods to create barcoded influenza viruses without disrupting the function of the viral proteins and the proper packaging of the viral genome segments are described. The barcoded influenza viruses can be used within deep mutational scanning libraries to map influenza resistance mutations to therapeutic treatments. The libraries can also be used to predict influenza strains that may become resistant to therapeutic treatments and/or more easily evolve to infect new species. The libraries include features that allow efficient collection and assessment of informative data, obviating bottlenecks of previous approaches.
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公开(公告)号：US20230313224A1
公开(公告)日：2023-10-05
申请号：US17995671
申请日：2021-04-12
发明人： Andre Lieber , Hans-Peter Kiem , Hongjie Wang
IPC分类号： C12N15/86 , C07K14/075 , C07K14/755 , C12N5/0789 , A61P7/00
CPC分类号： C12N15/86 , A61P7/00 , C07K14/075 , C07K14/755 , C12N5/0647 , C12N2710/10343 , C12N2800/90
摘要： The current disclosure provides recombinant adenoviral vectors and adenoviral genomes that can accommodate or that contain a large transposon payload, for instance a transposon payload of up to 40 kb. The adenoviral vectors and genomes can deliver the large transposon payload into a target genome, for instance for gene therapy.
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公开(公告)号：US20230312674A1
公开(公告)日：2023-10-05
申请号：US18053283
申请日：2022-11-07
发明人： Matthias Stephan
CPC分类号： C07K14/7051 , A61K47/6931 , A61K47/6849 , A61P35/00 , A61K39/001168 , A61K9/0019 , A61K39/39 , A61K2039/852 , A61K2039/555
摘要： Systems and methods to increase the efficacy of vaccines that require or are rendered more effective with T cell mediated immunity are described. The systems and methods utilize polynucleotides that genetically modify T cells to express a T cell receptor specific for an administered vaccine antigen.
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公开(公告)号：US11718876B2
公开(公告)日：2023-08-08
申请号：US17351135
申请日：2021-06-17
IPC分类号： C12Q1/6881 , C12Q1/6883
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present disclosure provides a panel of nucleic acid molecule primers specific for HLA-specific alleles and other genetic polymorphisms, which are useful for quantitatively amplifying these markers to detect, diagnose, and monitor individuals who have or are at risk of certain disease conditions, such as autoimmune disease, proliferative disease, infectious disease, allograft rejection, or pregnancy-related pathologies.
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公开(公告)号：US20230220103A1
公开(公告)日：2023-07-13
申请号：US17907648
申请日：2021-03-31
IPC分类号： C07K16/28 , C07K14/725 , C07K14/705 , C12N15/63
CPC分类号： C07K16/2896 , C07K14/7051 , C07K14/70521 , C12N15/63 , C07K2317/565 , C07K2317/622 , C07K2319/03 , C07K2317/526
摘要： Chimeric antigen receptors (CARs) with binding domains derived from a novel suite of human CD33-binding antibodies are described. The CARs include optimized short and intermediate spacer regions. The current disclosure also provides methods of cell expansion/activation processes utilizing IL-2, IL-7, IL-15, and/or IL-21 that improve cellular proliferation and cell lysis of the CARs as described.
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