公开(公告)号：US11332543B2

公开(公告)日：2022-05-17

申请号：US15761260

申请日：2016-10-04

申请人： FREDAX AB

发明人： Amanda Thuy Tran ,  Anders Axelsson ,  Cecilia Ann-Christin Malmborg Hager ,  Kjell Sjöström ,  Sven-Erik Strand ,  Urpo Juhani Lamminmäki

IPC分类号： A61K39/00 ,  C07K16/30 ,  A61K51/10 ,  A61K39/395 ,  A61K47/68 ,  A61P35/00 ,  G01N33/574

摘要： The present invention provides antibody polypeptides with binding specificity for prostate specific antigen (PSA), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO:1 and SEQ ID NO:2 and SEQ ID NO:3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO:4 and SEQ ID NO:5 and SEQ ID NO:6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The invention further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer.

公开(公告)号：US20220242969A1

公开(公告)日：2022-08-04

申请号：US17717254

申请日：2022-04-11

申请人： FREDAX AB

发明人： Amanda Thuy Tran ,  Anders Axelsson ,  Cecilia Ann-Christin Malmborg Hager ,  Kjell Sjöström ,  Sven-Erik Strand ,  Urpo Juhani Lamminmäki

IPC分类号： C07K16/30 ,  A61K51/10 ,  A61K39/395 ,  A61K47/68 ,  A61P35/00 ,  G01N33/574

摘要： The present invention provides antibody polypeptides with binding specificity for prostate specific antigen (PSA), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO:1 and SEQ ID NO:2 and SEQ ID NO:3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO:4 and SEQ ID NO:5 and SEQ ID NO:6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The invention further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer

公开(公告)号：US20180273634A1

公开(公告)日：2018-09-27

申请号：US15761260

申请日：2016-10-04

申请人： FREDAX AB

发明人： Amanda Thuy Tran ,  Anders Axelsson ,  Cecilia Ann-Christin Malmborg Hager ,  Kjell Sjöström ,  Sven-Erik Strand ,  Urpo Juhani Lamminmäki

IPC分类号： C07K16/30 ,  A61K47/68 ,  G01N33/574 ,  A61K51/10 ,  A61P35/00

CPC分类号： C07K16/3069 ,  A61K39/395 ,  A61K47/6803 ,  A61K47/6869 ,  A61K51/1072 ,  A61K51/1096 ,  A61K2039/505 ,  A61P35/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/57434

摘要： The present invention provides antibody polypeptides with binding specificity for prostate specific antigen (PSA), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO:1 and SEQ ID NO:2 and SEQ ID NO:3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO:4 and SEQ ID NO:5 and SEQ ID NO:6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The invention further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer