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公开(公告)号：US11332543B2
公开(公告)日：2022-05-17
申请号：US15761260
申请日：2016-10-04
申请人： FREDAX AB
发明人： Amanda Thuy Tran , Anders Axelsson , Cecilia Ann-Christin Malmborg Hager , Kjell Sjöström , Sven-Erik Strand , Urpo Juhani Lamminmäki
IPC分类号： A61K39/00 , C07K16/30 , A61K51/10 , A61K39/395 , A61K47/68 , A61P35/00 , G01N33/574
摘要： The present invention provides antibody polypeptides with binding specificity for prostate specific antigen (PSA), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO:1 and SEQ ID NO:2 and SEQ ID NO:3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO:4 and SEQ ID NO:5 and SEQ ID NO:6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The invention further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer.
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公开(公告)号：US10100125B2
公开(公告)日：2018-10-16
申请号：US15036170
申请日：2014-11-19
申请人： FREDAX AB
发明人： Par Oskar Vilhelmsson Timmermand , Amanda Thuy Tran , Sven-Erik Strand , Urpo Juhani Lamminmaki , Kjell Sjostrom
摘要： The present invention provides antibody polypeptides with binding specificity for human kallikrein-2 (hK2), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2 and SEQ ID NO: 3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO: 4 and SEQ ID NO: 5 and SEQ ID NO: 6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The invention further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer.
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公开(公告)号：US20180273634A1
公开(公告)日：2018-09-27
申请号：US15761260
申请日：2016-10-04
申请人： FREDAX AB
发明人： Amanda Thuy Tran , Anders Axelsson , Cecilia Ann-Christin Malmborg Hager , Kjell Sjöström , Sven-Erik Strand , Urpo Juhani Lamminmäki
IPC分类号： C07K16/30 , A61K47/68 , G01N33/574 , A61K51/10 , A61P35/00
CPC分类号： C07K16/3069 , A61K39/395 , A61K47/6803 , A61K47/6869 , A61K51/1072 , A61K51/1096 , A61K2039/505 , A61P35/00 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/624 , C07K2317/92 , C07K2317/94 , G01N33/57434
摘要： The present invention provides antibody polypeptides with binding specificity for prostate specific antigen (PSA), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO:1 and SEQ ID NO:2 and SEQ ID NO:3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO:4 and SEQ ID NO:5 and SEQ ID NO:6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The invention further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer
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公开(公告)号：US20160369009A1
公开(公告)日：2016-12-22
申请号：US15036170
申请日：2014-11-19
申请人： FREDAX AB
发明人： Par Oskar Vilhelmsson Timmermand , Amanda Thuy Tran , Sven-Erik Strand , Urpo Juhani Lamminmaki
CPC分类号： C07K16/40 , A61K51/1045 , A61K51/1075 , A61K51/1096 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The present invention provides antibody polypeptides with binding specificity for human kallikrein-2 (hK2), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2 and SEQ ID NO: 3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO: 4 and SEQ ID NO: 5 and SEQ ID NO: 6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The invention further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer.
摘要翻译： 本发明提供对人激肽释放酶-2（hK2）具有结合特异性的抗体多肽，其中所述抗体多肽包含（a）包含SEQ ID NO：1和SEQ ID NO：2和SEQ ID NO：2的氨基酸序列的重链可变区 （SEQ ID NO：3）和/或（b）包含SEQ ID NO：4和SEQ ID NO：5和SEQ ID NO：6的氨基酸序列的轻链可变区，其中重链可变区和轻链可变区 区域包含来自一个或多个人抗体的框架氨基酸序列。 本发明进一步提供所述抗体多肽在前列腺癌的诊断和治疗中的用途。
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公开(公告)号：US20220242969A1
公开(公告)日：2022-08-04
申请号：US17717254
申请日：2022-04-11
申请人： FREDAX AB
发明人： Amanda Thuy Tran , Anders Axelsson , Cecilia Ann-Christin Malmborg Hager , Kjell Sjöström , Sven-Erik Strand , Urpo Juhani Lamminmäki
IPC分类号： C07K16/30 , A61K51/10 , A61K39/395 , A61K47/68 , A61P35/00 , G01N33/574
摘要： The present invention provides antibody polypeptides with binding specificity for prostate specific antigen (PSA), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO:1 and SEQ ID NO:2 and SEQ ID NO:3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO:4 and SEQ ID NO:5 and SEQ ID NO:6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The invention further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer
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公开(公告)号：US20160317683A1
公开(公告)日：2016-11-03
申请号：US15135028
申请日：2016-04-21
申请人： FredAx AB
CPC分类号： A61K51/1072 , A61K47/6803 , A61K49/16 , A61K49/221 , A61K51/1018 , A61K51/1075 , A61K51/1093 , A61K51/1096 , C07K16/18 , C07K16/3069 , C07K16/40 , C07K2317/565 , G01N33/57434 , G01N2333/96455
摘要： The present application provides an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein (for example, PSA or hK2) for use in the treatment of prostate cancer, and a method for the treatment of prostate cancer in a patient, the method comprising the step of administering a therapeutically effective amount of an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein to the patient.
摘要翻译： 本申请提供了一种包含或组成具有对用于治疗前列腺癌的激肽释放酶蛋白（例如PSA或hK2）的特异性的结合部分的药物，以及用于治疗患者中前列腺癌的方法， 方法包括给患者施用治疗有效量的包含结合部分或由激肽释放酶蛋白的特异性组成的试剂。
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公开(公告)号：US09345782B2
公开(公告)日：2016-05-24
申请号：US14354617
申请日：2012-10-26
申请人： FREDAX AB
IPC分类号： A61K39/00 , A61K47/48 , A61K51/10 , C07K16/30 , G01N33/574 , A61K49/16 , A61K49/22 , C07K16/18
CPC分类号： A61K51/1072 , A61K47/6803 , A61K49/16 , A61K49/221 , A61K51/1018 , A61K51/1075 , A61K51/1093 , A61K51/1096 , C07K16/18 , C07K16/3069 , C07K16/40 , C07K2317/565 , G01N33/57434 , G01N2333/96455
摘要： The present application provides an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein (for example, PSA or hK2) for use in the treatment of prostate cancer, and a method for the treatment of prostate cancer in a patient, the method comprising the step of administering a therapeutically effective amount of an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein to the patient.
摘要翻译： 本申请提供了一种包含或组成具有对用于治疗前列腺癌的激肽释放酶蛋白（例如PSA或hK2）的特异性的结合部分的药物，以及用于治疗患者中前列腺癌的方法， 方法包括给患者施用治疗有效量的包含结合部分或由激肽释放酶蛋白的特异性组成的试剂。
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公开(公告)号：US20140286862A1
公开(公告)日：2014-09-25
申请号：US14354617
申请日：2012-10-26
申请人： FREDAX AB
CPC分类号： A61K51/1072 , A61K47/6803 , A61K49/16 , A61K49/221 , A61K51/1018 , A61K51/1075 , A61K51/1093 , A61K51/1096 , C07K16/18 , C07K16/3069 , C07K16/40 , C07K2317/565 , G01N33/57434 , G01N2333/96455
摘要： The present application provides an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein (for example, PSA or hK2) for use in the treatment of prostate cancer, and a method for the treatment of prostate cancer in a patient, the method comprising the step of administering a therapeutically effective amount of an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein to the patient.
摘要翻译： 本申请提供了一种包含或组成具有对用于治疗前列腺癌的激肽释放酶蛋白（例如PSA或hK2）的特异性的结合部分的药物，以及用于治疗患者中前列腺癌的方法， 方法包括给患者施用治疗有效量的包含结合部分或由激肽释放酶蛋白的特异性组成的试剂。
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