公开(公告)号：US10100125B2

公开(公告)日：2018-10-16

申请号：US15036170

申请日：2014-11-19

申请人： FREDAX AB

发明人： Par Oskar Vilhelmsson Timmermand ,  Amanda Thuy Tran ,  Sven-Erik Strand ,  Urpo Juhani Lamminmaki ,  Kjell Sjostrom

IPC分类号： C07K16/40 ,  C07K16/30 ,  A61K51/10 ,  A61K39/00

摘要： The present invention provides antibody polypeptides with binding specificity for human kallikrein-2 (hK2), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2 and SEQ ID NO: 3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO: 4 and SEQ ID NO: 5 and SEQ ID NO: 6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The invention further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer.