公开(公告)号：US10525141B2

公开(公告)日：2020-01-07

申请号：US15566717

申请日：2016-04-15

Applicant: FREIE UNIVERSITÄT BERLIN

Inventor： Rainer Haag ,  Sabine Reimann ,  Jens Dernedde

IPC: A61K47/10 ,  A61K47/60 ,  C08G65/22 ,  C08G65/34 ,  C08G83/00

Abstract: It is provided a polyglycerol derivative, comprising a dendritic polyglycerol backbone and at least one substituent in the nature of a covalently bound negatively charged group chosen from the group consisting of sulfates, sulfonates, phosphates, phosphonates, bisphosphonates, carboxylates and combinations thereof. The substituent is bound to the polyglycerol backbone via a linker, the linker being chosen from the group consisting of moieties being or comprising a carbamate group, an ester group, an orthoester group, an amide group, a disulfide bridge group, an acetal group, an imine group and combinations thereof.