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    METHOD FOR PRODUCING A POLYGLYCEROL NANOGEL FOR THE ENCAPSULATION AND RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES
    1.
    发明申请
    METHOD FOR PRODUCING A POLYGLYCEROL NANOGEL FOR THE ENCAPSULATION AND RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES 有权
    用于生物活性物质包埋和释放的聚甘油纳米粒子的方法

    公开(公告)号：US20150283094A1

    公开(公告)日：2015-10-08

    申请号：US14426713

    申请日：2013-09-05

    Applicant: FREIE UNIVERSITÄT BERLIN ,  LUDWIG-MAXIMILIANS-UNIVRSITÄT

    Inventor： Rainer Haag ,  Dirk Steinhilber ,  Wolfgang Friess ,  Sarah Hedtrich (Born Küchler) ,  Madeleine Witting

    IPC: A61K9/51 ,  A61K38/38 ,  C07K16/00 ,  A61K38/50

    CPC classification number: A61K9/5146 ,  A61K9/06 ,  A61K9/5192 ,  A61K38/385 ,  A61K38/50 ,  B01J13/0065 ,  C07K16/00 ,  C12Y302/01017 ,  C12Y305/01001

    Abstract: A method for producing a polyglycerol nanogel is disclosed, the method comprising the following steps: Mixing an aqueous solution of first polyglycerol macromonomers, which are modified with a first reactive group, with an aqueous solution of second polyglycerol macromonomers, which are modified with a second reactive group, wherein the first reactive group and the second reactive group can react with each other forming a chemical bond; transferring the mixture into an organic non-solvent; and precipitation of a polyglycerol nanogel consisting of first polyglycerol macromonomers and second polyglycerol macromonomers which are covalently bound to each other. According to an aspect of the invention, the method is characterized in that the organic non-solvent is miscible with water and in that the method is carried out without adding surface-active substances.

    Abstract translation: 公开了一种聚甘油纳米凝胶的制造方法，该方法包括以下步骤：将第一聚甘油大分子单体的第一聚甘油大分子单体的水溶液与第二聚甘油大分子单体的水溶液混合， 反应性基团，其中第一反应性基团和第二反应性基团可以彼此反应形成化学键; 将混合物转移到有机非溶剂中; 和由共价键合的第一聚甘油大分子单体和第二聚甘油大分子单体组成的聚甘油纳米凝胶的沉淀。 根据本发明的一个方面，该方法的特征在于有机非溶剂与水混溶，并且该方法在不添加表面活性物质的情况下进行。

    Polyglycerol derivative and a method for manufacturing the same
    3.
    发明授权
    Polyglycerol derivative and a method for manufacturing the same 有权

    公开(公告)号：US10525141B2

    公开(公告)日：2020-01-07

    申请号：US15566717

    申请日：2016-04-15

    Applicant: FREIE UNIVERSITÄT BERLIN

    Inventor： Rainer Haag ,  Sabine Reimann ,  Jens Dernedde

    IPC: A61K47/10 ,  A61K47/60 ,  C08G65/22 ,  C08G65/34 ,  C08G83/00

    Abstract: It is provided a polyglycerol derivative, comprising a dendritic polyglycerol backbone and at least one substituent in the nature of a covalently bound negatively charged group chosen from the group consisting of sulfates, sulfonates, phosphates, phosphonates, bisphosphonates, carboxylates and combinations thereof. The substituent is bound to the polyglycerol backbone via a linker, the linker being chosen from the group consisting of moieties being or comprising a carbamate group, an ester group, an orthoester group, an amide group, a disulfide bridge group, an acetal group, an imine group and combinations thereof.

    Amphiphilic block copolymer and coating arrangement
    4.
    发明授权
    Amphiphilic block copolymer and coating arrangement 有权

    公开(公告)号：US11041090B2

    公开(公告)日：2021-06-22

    申请号：US16314630

    申请日：2017-06-30

    Applicant: FREIE UNIVERSITÄT BERLIN

    Inventor： Rainer Haag ,  Marie Weinhart ,  Qiang Wei ,  Leixiao Yu

    IPC: C09D171/02 ,  C12M1/00 ,  C08G83/00 ,  C09D201/00 ,  C08G65/00 ,  C09D201/06 ,  C09D201/02 ,  C08G65/22 ,  C08G65/334 ,  C09D5/00

    Abstract: The disclosure relates to an amphiphilic block copolymer comprising a first block consisting of a polymeric hydrophilic domain, wherein the polymeric hydrophilic domain consists of a polyglycerol; an optional second block consisting of a hydrophobic domain and a first linker domain, wherein the second block is covalently bound to the first block via the first linker domain, an optional third block consisting of a catechol domain and a second linker domain, wherein the third block is covalently bound to the first block via the second linker domain; and a fourth block consisting of a crosslinking domain and a third linker domain, wherein the fourth block is covalently bound to the first block via the third linker domain, wherein the crosslinking domain comprises a reactive residue enabling a crosslinking between individual molecules of the amphiphilic block copolymer.

    Bioinert article and its use
    5.
    发明授权
    Bioinert article and its use 有权

    公开(公告)号：US10047230B2

    公开(公告)日：2018-08-14

    申请号：US15021250

    申请日：2014-09-08

    Applicant: FREIE UNIVERSITÄT BERLIN

    Inventor： Rainer Haag ,  Marie Weinhart ,  Qiang Wei ,  Tobias Becherer ,  Ingo Grunwald

    IPC: A61F2/02 ,  C09D5/16 ,  C08G83/00 ,  A61L27/34 ,  C08J7/04 ,  C09D201/00 ,  C09D201/06 ,  C08L101/00 ,  C12M1/00 ,  A61F2/00 ,  C09D171/00

    Abstract: An article, comprising a substrate and a polymer film attached to the substrate is provided, the polymer film comprising a first layer of a first polymer functionalized by a first functionalization compound covalently bound to said first polymer and bearing at least one catecholic group being present on a surface of the first layer. The polymer film is a layered film, a top layer of which is formed by the first layer, the layered film comprising at least one further layer of at least one further polymer functionalized by a further functionalization compound covalently bound to said further polymer and bearing at least one catecholic group being present on a surface of the at least one further layer, wherein an average ratio of catecholic groups per polymer molecule is equal to or less than 1 in case of the first polymer and greater than 1 in case of the further polymer.

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