公开(公告)号：US20230138930A1

公开(公告)日：2023-05-04

申请号：US18050240

申请日：2022-10-27

申请人： FUDAN UNIVERSITY ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES ,  SHANGHAI MIRACOGEN INC.

发明人： Ke YU ,  Jingkang SHEN ,  Tao MENG ,  Lanping MA ,  Xuesai ZHANG ,  Qingrou LI ,  Qing LIN

IPC分类号： A61K47/68 ,  C07K16/36 ,  A61P35/00 ,  A61K31/537 ,  A61K47/54 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/5365

摘要： A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

公开(公告)号：US20210214447A1

公开(公告)日：2021-07-15

申请号：US17055499

申请日：2019-05-10

申请人： FUDAN UNIVERSITY ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Ke YU ,  Jingkang SHEN ,  Tao MENG ,  Jinpeng PEI ,  Lanping MA ,  Xin WANG ,  Rui JIN ,  Zhiyan DU ,  Lin CHEN ,  Ting YU ,  Yongliang ZHANG

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61K45/06 ,  A61P35/00

摘要： Disclosed are a new AXL-targeting monoclonal antibody and antibody-drug conjugate. Also disclosed is a method for preparing said antibody and antibody-drug conjugate. The AXL antibody of the present invention can bind with purified humanAXL protein and multiple AXL on tumor cell surface with high effectiveness and high specificity. Said humanized antibody also has high affinity and low immunogenicity. Said AXL antibody-drug conjugate has markable performance against tumors having high AXL expression.

公开(公告)号：US20180079749A1

公开(公告)日：2018-03-22

申请号：US15561003

申请日：2016-03-24

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA,CHINESE ACADEMY OF SCIENCES ,  SHANDONG LUOXIN PHARMACEUTICAL GROUP STOCK CO., LTD.

发明人： Jingkang SHEN ,  Tao MENG ,  Ting YU ,  Lanping MA ,  Xin WANG ,  Lin CHEN

IPC分类号： C07D471/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D519/00

摘要： Provided is a process of synthesizing a substituted pyridine and pyrimidine compound. Particularly, provided is a method for preparing a compound of formula III via a compound of formula II′, wherein the definition of each of groups is as described as the description. Compound with other methods, the method in the present invention has features of high yield and a result product being easier to separate.