公开(公告)号：US20170081289A1

公开(公告)日：2017-03-23

申请号：US15312111

申请日：2015-05-20

Applicant: FUJI CHEMICAL INDUSTRIES CO., LTD.

Inventor： Takashi FUJITA ,  Satochi KOBAYASHI ,  Ryoma SHINOHARA ,  Yasuhiro NISHIDA ,  Jiro TAKAHASHI

IPC: C07D233/61 ,  C07C403/24

CPC classification number: C07D233/61 ,  A61K31/22 ,  A61K31/27 ,  A61K31/4178 ,  C07C403/24

Abstract: The object of the present invention is to find a carotenoid compound that is excellent in water solubility.A carotenoid derivative having a formula (I): wherein X represents a carbonyl group or a methylene group, one of R1 and R2 represents (a) or (b) and the other represents (a), (b), (c) or a hydrogen atom: (a): —CO-A-B-D wherein A represents an alkylene group an alkenylene group, etc., B represents a formula of —S(O)n— or a formula of —NR4CONR5— and D represents a hydrogen atom, a carboxy group, etc., (b): —CO-E-F wherein E represents an alkylene group or a formula of —NR3— wherein R3 represents (a1) a hydrogen atom, (b1) an alkyl group etc., and F represents a sulfo group and (c): —CO-G wherein G represents a hydrogen atom, an alkyl group, etc., a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester or amide thereof.