公开(公告)号：US20220281899A1

公开(公告)日：2022-09-08

申请号：US17742390

申请日：2022-05-11

Applicant: FUJIFILM Corporation

Inventor： Hiyoku NAKATA ,  Masato SAKAKIBARA ,  Akihiro ASAKURA ,  Keiko MAKITA

IPC: C07F5/02 ,  A61K49/00

Abstract: Provided are the following compound and a fluorescently labeled biological substance having this fluorescent compound. X represents CR7 or N.
R1 to R7, Q1, and Q2 represent a hydrogen atom, a halogen atom, a cyano group, or a group represented by Formula (A), and adjacent substituents may form a ring structure.
However, at least one of R3, R4, R7, Q1, or Q2 contains, as a hydrophilic group, at least one of a carboxy group or a salt thereof, a sulfo group or a salt thereof, a phosphono group or a salt thereof, an onio group, or a polyamino acid residue, where at least one of Q1 or Q2 represents an alkyl group.

公开(公告)号：US20200342599A1

公开(公告)日：2020-10-29

申请号：US16928974

申请日：2020-07-14

Applicant: FUJIFILM Corporation

Inventor： Sohichiro NAKAMURA ,  Ryusuke OSAKI ,  Sho ONOZAWA ,  Akihiro ASAKURA

IPC: G06T7/00 ,  G06T7/62 ,  G01N21/45 ,  G01N15/06 ,  C12Q1/02

Abstract: Provided is a determination method capable of non-destructively and simply determining a state of a sphere that is an aggregate of a plurality of cells. A phase difference image of a sphere that is an aggregate of a plurality of cells is generated from a hologram obtained by imaging the sphere, and a state of the sphere is determined on the basis of the phase difference image and a shape index value corresponding to a shape of the sphere.

公开(公告)号：US20210088526A1

公开(公告)日：2021-03-25

申请号：US17105638

申请日：2020-11-27

Applicant: FUJIFILM Corporation

Inventor： Hiyoku NAKATA ,  Kousuke WATANABE ,  Akihiro ASAKURA ,  Keiko MAKITA ,  Yoshinori KANAZAWA ,  Kazuhei KANEKO

IPC: G01N33/58 ,  C09K11/06 ,  C09B23/06 ,  G01N21/64

Abstract: Provided are any one of the following fluorescent compounds and a fluorescent labeled biological substance having this fluorescent compound. X represents CR5 or N, and R1 to R7, Q1, Q2, L1, and L2 each represent a specific group.
a ring β1 and a ring β2 are a 5- to 8-membered ring,
At least one of R1 to R7, L1, L2, Q1, or Q2 has a specific hydrophilic group.
However, in a case where the ring β1 and the ring β2 are a 6-membered ring, and L1 and L2 are an arylene group, R5 is not an aryl group substituted with a linear alkyl group having 18 or more carbon atoms. In addition to the regulation of the ring β1, the ring β2, L1, and L2, in a case where R5 has a substituent having a dipyrromethene boron complex structure, the dipyrromethene boron complex structure has a structure in which a dipyrromethene skeleton is coordinately bonded to a boron atom in the tridentate or tetradentate coordination.