公开(公告)号：US20230348779A1

公开(公告)日：2023-11-02

申请号：US18347582

申请日：2023-07-06

Applicant: FUJIFILM Corporation

Inventor： Masato SAKAKIBARA ,  Hiyoku NAKATA ,  Hiroaki TANAKA

IPC: C09K11/06 ,  G01N33/533

CPC classification number: C09K11/06 ,  G01N33/533 ,  C09K2211/1096

Abstract: There are provided a fluorescent compound of the following formula or a salt thereof and a labeled biological substance.






Y represents —NR10R11 or —OR12, and R1 to R12, R21 to R23, and Z represent specific groups and satisfy the following regulations.
At least one of R21 or R22 is an alkenyl group, an alkynyl group, an aryl group, or a heteroaryl group. In a case of R21=an aryl group and R22=an alkyl group or an aryl group, at least R7 and R8, or R10 and R11 are bonded to each other to form a 4-membered ring.
A compound of Formula (I) or (II) or a salt thereof satisfies condition α, and a compound of Formula (III) or (IV) or a salt thereof satisfies condition β.
(Condition α)
In a case where Z is an aryl group, the aryl group has a specific structure.
(Condition β)
At least R7 and R8, or R10 and R11 are bonded to each other to form a 4-membered ring.

公开(公告)号：US20220281899A1

公开(公告)日：2022-09-08

申请号：US17742390

申请日：2022-05-11

Applicant: FUJIFILM Corporation

Inventor： Hiyoku NAKATA ,  Masato SAKAKIBARA ,  Akihiro ASAKURA ,  Keiko MAKITA

IPC: C07F5/02 ,  A61K49/00

Abstract: Provided are the following compound and a fluorescently labeled biological substance having this fluorescent compound. X represents CR7 or N.
R1 to R7, Q1, and Q2 represent a hydrogen atom, a halogen atom, a cyano group, or a group represented by Formula (A), and adjacent substituents may form a ring structure.
However, at least one of R3, R4, R7, Q1, or Q2 contains, as a hydrophilic group, at least one of a carboxy group or a salt thereof, a sulfo group or a salt thereof, a phosphono group or a salt thereof, an onio group, or a polyamino acid residue, where at least one of Q1 or Q2 represents an alkyl group.