COMBINED PHARMACEUTICAL FORMULATION COMPRISING DRUG-CONTAINING LIPOSOME COMPOSITION AND PLATINUM PREPARATION

    公开(公告)号:US20210213051A1

    公开(公告)日:2021-07-15

    申请号:US17219064

    申请日:2021-03-31

    Abstract: An object of the present invention is to provide a pharmaceutical formulation obtained by combining a liposome composition, in which liposomes encapsulate a drug, with a platinum preparation. According to the present invention, there is provided a pharmaceutical formulation including (A) a liposome composition in combination with (B) a platinum preparation, in which the liposome composition includes, as constitutional components of a liposome membrane, a hydrophilic polymer-modified diacylphosphatidylethanolamine; a dihydrosphingomyelin; and cholesterols, the liposome composition includes a drug and has an inner water phase containing ammonium sulfate, a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more, and the liposome composition and the platinum preparation are administered simultaneously or sequentially.

Patent Agency Ranking