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公开(公告)号：US20210100745A1
公开(公告)日：2021-04-08
申请号：US17121870
申请日：2020-12-15
Applicant: FUJIFILM Corporation
Inventor： Makoto ONO , Kohei ONO , Takeshi MATSUMOTO , Mikinaga MORI
Abstract: Provided are a liposome composition which has a practically required long-term preservation stability, and which has a release rate of a drug on the order of several tens of hours due to releasability of a drug being able to be suitably controlled by rendering an inner water phase hyper-osmotic; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which the content of cholesterols is 10 mol % to 35 mol % with respect to the total amount of lipid components in the liposome composition, and each of the liposomes encapsulates a drug in a dissolved state, and an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase.
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公开(公告)号：US20170202774A1
公开(公告)日：2017-07-20
申请号：US15474644
申请日：2017-03-30
Applicant: FUJIFILM Corporation
Inventor： Makoto ONO , Kohei ONO , Takeshi MATSUMOTO , Mikinaga MORI
IPC: A61K9/127 , A61K31/7068
CPC classification number: A61K9/127 , A61K9/1278 , A61K31/7068 , A61K47/24 , A61K47/28 , B82Y5/00
Abstract: Provided are a liposome composition in which an osmotic pressure of an inner water phase is 2-fold to 8-fold relative to the osmotic pressure of an outer water phase, and which encapsulates a water-soluble drug in a dissolved state, and also exhibits excellent preservation stability; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes obtained from lipids dissolved and emulsified in an organic solvent, each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which each of the liposomes encapsulates a water-soluble drug in a dissolved state, and an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase; and a method for producing the same.
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公开(公告)号：US20130084580A1
公开(公告)日：2013-04-04
申请号：US13625542
申请日：2012-09-24
Applicant: FUJIFILM Corporation
Inventor： Atsuhiko WADA , Mikinaga MORI
CPC classification number: G01N33/553 , G01N33/54386
Abstract: A chromatographic kit is provided including a labeling substance holding area having a labeling substance modified with a first binding substance of a test substance, and a labeling substance capturing area having a second binding substance of the test substance or a binding substance of the first binding substance in this order from upstream to downstream of a development direction of a test sample including the test substance, and further including an area having a color developing reagent in order to detect a first amplification reagent of two types of amplification reagents used to amplify the signal of the labeling substance when detecting the labeling substance.
Abstract translation: 提供了一种色谱试剂盒，其包括具有被测试物质的第一结合物质改性的标记物质的标记物质保存区域和具有测试物质的第二结合物质或第一结合物质的结合物质的标记物质捕获区域 从包含测试物质的测试样品的显影方向的上游到下游的顺序，并且还包括具有显色剂的区域，以便检测用于放大信号的两种类型的扩增试剂的第一扩增试剂 检测标签物质时的标记物质。
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公开(公告)号：US20180243215A1
公开(公告)日：2018-08-30
申请号：US15968110
申请日：2018-05-01
Applicant: FUJIFILM Corporation
Inventor： Takahiro SEKIGUCHI , Mikinaga MORI , Kentaro NUMAJIRI , Hiroyuki KITAOKA
IPC: A61K9/127 , A61K31/7068
CPC classification number: A61K9/127 , A61K9/1271 , A61K9/1278 , A61K31/7068
Abstract: An object of the present invention is to provide a liposome composition containing a liposome having an excellent leakage rate of a nucleic acid analog anticancer agent, and a method for producing the same. According to the present invention, there are provided a liposome composition containing a liposome which (1) contains a nucleic acid analog anticancer agent and in which (2) a content ratio of a lysophospholipid contained in a lipid forming the liposome with respect to a total amount of phospholipids other than the lysophospholipid contained in the lipid forming the liposome is 0.01 mol % to 5 mol % and (3) a nucleic acid analog anticancer agent/lipid ratio is 2 mass % to 10 mass %, and a method for producing the same.
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公开(公告)号：US20140093868A1
公开(公告)日：2014-04-03
申请号：US14098798
申请日：2013-12-06
Applicant: FUJIFILM Corporation
Inventor： Atsuhiko WADA , Mikinaga MORI
IPC: G01N33/553
CPC classification number: G01N33/553 , G01N33/54386
Abstract: A chromatographic kit is provided including a labeling substance holding area having a labeling substance modified with a first binding substance of a test substance, and a labeling substance capturing area having a second binding substance of the test substance or a binding substance of the first binding substance in this order from upstream to downstream of a development direction of a test sample including the test substance, and further including an area having a color developing reagent in order to detect a first amplification reagent of two types of amplification reagents used to amplify the signal of the labeling substance when detecting the labeling substance.
Abstract translation: 提供了一种色谱试剂盒，其包括具有被测试物质的第一结合物质改性的标记物质的标记物质保存区域和具有测试物质的第二结合物质或第一结合物质的结合物质的标记物质捕获区域 从包含测试物质的测试样品的显影方向的上游到下游的顺序，并且还包括具有显色剂的区域，以便检测用于放大信号的两种类型的扩增试剂的第一扩增试剂 检测标签物质时的标记物质。
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Patent Agency Ranking
公开(公告)号：US20210128471A1
公开(公告)日：2021-05-06
申请号：US17140502
申请日：2021-01-04
Applicant: FUJIFILM Corporation
Inventor： Takahiro SEKIGUCHI , Mikinaga MORI , Kentaro NUMAJIRI , Hiroyuki KITAOKA
IPC: A61K9/127 , A61K31/7068
Abstract: An object of the present invention is to provide a liposome composition containing a liposome having an excellent leakage rate of a nucleic acid analog anticancer agent, and a method for producing the same. According to the present invention, there are provided a liposome composition containing a liposome which (1) contains a nucleic acid analog anticancer agent and in which (2) a content ratio of a lysophospholipid contained in a lipid forming the liposome with respect to a total amount of phospholipids other than the lysophospholipid contained in the lipid forming the liposome is 0.01 mol % to 5 mol % and (3) a nucleic acid analog anticancer agent/lipid ratio is 2 mass % to 10 mass %, and a method for producing the same.
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公开(公告)号：US20200016079A1
公开(公告)日：2020-01-16
申请号：US16583518
申请日：2019-09-26
Applicant: FUJIFILM Corporation
Inventor： Noriyuki KASAGI , Naoki YAMADA , Mikinaga MORI , Takayuki KATO , Takayuki KOBAYASHI
Abstract: An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.
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公开(公告)号：US20180243214A1
公开(公告)日：2018-08-30
申请号：US15967970
申请日：2018-05-01
Applicant: FUJIFILM Corporation
Inventor： Tsukasa KITAHASHI , Shinji MIMA , Takeshi MATSUMOTO , Takahiro SEKIGUCHI , Mikinaga MORI
IPC: A61K9/127 , A61K31/7068 , A61K31/337 , A61K47/28 , A61K47/24 , A61P35/00
CPC classification number: A61K9/127 , A61K31/337 , A61K31/7068 , A61K47/24 , A61K47/28 , A61P35/00 , A61K2300/00
Abstract: An object of the present invention is to provide a tumor therapeutic agent and a kit which have superior antitumor effects as compared with gemcitabine, a taxane antitumor agent, and a combination therapy thereof which have been put on the market. According to the present invention, there is provided a tumor therapeutic agent obtained by combining a taxane antitumor agent with a liposome composition in which gemcitabine or a salt thereof is contained in a liposome.
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公开(公告)号：US20210275453A1
公开(公告)日：2021-09-09
申请号：US17184928
申请日：2021-02-25
Applicant: FUJIFILM Corporation
Inventor： Tsukasa KITAHASHI , Shinji MIMA , Takeshi MATSUMOTO , Takahiro SEKIGUCHI , Mikinaga MORI
IPC: A61K9/127 , A61K47/24 , A61K47/28 , A61K31/337 , A61K31/7068 , A61P35/00
Abstract: An object of the present invention is to provide a tumor therapeutic agent and a kit which have superior antitumor effects as compared with gemcitabine, a taxane antitumor agent, and a combination therapy thereof which have been put on the market. According to the present invention, there is provided a tumor therapeutic agent obtained by combining a taxane antitumor agent with a liposome composition in which gemcitabine or a salt thereof is contained in a liposome.
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10.发明申请公开(公告)号：US20210213051A1
公开(公告)日：2021-07-15
申请号：US17219064
申请日：2021-03-31
Applicant: FUJIFILM Corporation
Inventor： Ken OKADA , Susumu SHIMOYAMA , Mikinaga MORI
IPC: A61K33/243 , A61K9/127 , A61K31/4745 , A61K31/704 , A61K31/404 , A61K31/282 , A61P35/00
Abstract: An object of the present invention is to provide a pharmaceutical formulation obtained by combining a liposome composition, in which liposomes encapsulate a drug, with a platinum preparation. According to the present invention, there is provided a pharmaceutical formulation including (A) a liposome composition in combination with (B) a platinum preparation, in which the liposome composition includes, as constitutional components of a liposome membrane, a hydrophilic polymer-modified diacylphosphatidylethanolamine; a dihydrosphingomyelin; and cholesterols, the liposome composition includes a drug and has an inner water phase containing ammonium sulfate, a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more, and the liposome composition and the platinum preparation are administered simultaneously or sequentially.
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