公开(公告)号：US20210024543A1

公开(公告)日：2021-01-28

申请号：US17063110

申请日：2020-10-05

Applicant: FUJIFILM Corporation

Inventor： Muneo SHOJI ,  Kentaro FURUYA ,  Kei MATSUURA ,  Tomofumi NAKAE

IPC: C07D499/897 ,  A61P31/04

Abstract: An object of the present invention is to provide a compound and a pharmaceutical composition which exhibit strong antibacterial activity against Gram-negative bacteria and drug-resistant Gram-negative bacteria. A compound represented by General Formula [1] (the reference signs in Formula have the same definitions as those described in the present specification) or a salt thereof has strong antibacterial activity against Gram-negative bacteria such as Pseudomonas aeruginosa and drug-resistant Gram-negative bacteria including multidrug-resistant Pseudomonas aeruginosa, and the pharmaceutical composition containing the compound or a salt thereof is useful as an antibacterial agent.

公开(公告)号：US20190077761A1

公开(公告)日：2019-03-14

申请号：US15743758

申请日：2016-07-15

Applicant: FUJIFILM Corporation ,  TOYAMA CHEMICAL CO., LTD.

Inventor： Tadashi TANAKA ,  Masataka FUJINO ,  Kentaro FURUYA

IPC: C07D215/48 ,  C07D215/38 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D409/12 ,  C07D413/04 ,  C07D413/14 ,  A61P37/02

Abstract: A compound represented by the general formula, or a salt thereof, has exceptional CXCL10 inhibitory activity and is useful as a treatment agent for the prevention and/or treatment, etc., of diseases involving overproduction of CXCL10. In the formula: R1 is a C1-6 alkyl group, etc.; R2 is a hydrogen atom, etc.; R3 is a halogen atom, etc.; Z1, Z2, and Z3 are CH, etc.; X1 is CONH, etc.; ring A is a phenyl group, etc.; R4 is a halogen atom, etc.; and m is an integer of 0-5.

公开(公告)号：US20200239495A1

公开(公告)日：2020-07-30

申请号：US16839563

申请日：2020-04-03

Applicant: FUJIFILM Corporation

Inventor： Muneo SHOJI ,  Kentaro FURUYA ,  Kei MATSUURA ,  Hiromi HAYASHI ,  Tetsuya MATSUSHITA ,  Hirofumi OMURA

IPC: C07D499/897

Abstract: An object of the present invention is to provide a compound and a pharmaceutical composition which exhibit strong antibacterial activity against Gram-negative bacteria and drug-resistant Gram-negative bacteria. According to the present invention, a compound represented by General Formula [1] (the reference signs in the formula have the same definitions as those described in the present specification) or a salt thereof has strong antibacterial activity against Gram-negative bacteria such as Pseudomonas aeruginosa and drug-resistant Gram-negative bacteria including multidrug-resistant Pseudomonas aeruginosa, and the pharmaceutical composition containing the compound or a salt thereof is useful as an antibacterial agent.

公开(公告)号：US20190314360A1

公开(公告)日：2019-10-17

申请号：US16453393

申请日：2019-06-26

Applicant: FUJIFILM Corporation ,  FUJIFILM Toyama Chemical Co., Ltd. ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Keiko MAKITA ,  Kazunori SAEKI ,  Tadashi TANAKA ,  Masataka FUJINO ,  Tohru NATSUME ,  Kentaro FURUYA

IPC: A61K31/4704 ,  A61K31/5377 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/497 ,  A61P35/02 ,  A61P35/00

Abstract: It is an object of the present invention to provide an antitumor agent, which is further excellent as a treatment agent used in the prevention and/or therapy of tumor associated with a bromodomain, and also to provide a bromodomain inhibitor, which is useful as a treatment agent for diseases or states associated with a bromodomain.An antitumor agent and a bromodomain inhibitor, comprising a compound represented by the following formula, have an excellent bromodomain inhibitory activity and are useful as treatment agents in the prevention and/or therapy of tumor associated with a bromodomain, and the like: wherein R1 represents a C1-6 alkyl group, etc.; R2 represents a hydrogen atom, etc.; R3 represents a halogen atom, etc.; Z1, Z2 and Z3 each represent CH, etc.; X1 represents CONH, etc.; Ring A represents a phenyl group, etc.; R4 represents a halogen atom, etc.; and m represents an integer from 0 to 5.