公开(公告)号：US11154534B2

公开(公告)日：2021-10-26

申请号：US16448069

申请日：2019-06-21

Applicant: FUJIFILM Corporation

Inventor： Yuta Yoshino ,  Hayato Ogura ,  Mikinaga Mori ,  Taisuke Endo ,  Kentaro Numajiri ,  Ritsuko Hori

IPC: A61K31/4045 ,  A61K9/127 ,  A61K35/00

Abstract: An object of the present invention is to provide a lipid particle composition containing panobinostat or a salt thereof and exhibiting a high bone marrow-targeting capability, and a pharmaceutical composition including the lipid particle composition. According to the present invention, provided is a lipid particle composition containing panobinostat or a salt thereof, in which a lipid particle contains a phospholipid and cholesterol.

公开(公告)号：US12220482B2

公开(公告)日：2025-02-11

申请号：US17140502

申请日：2021-01-04

Applicant: FUJIFILM Corporation

Inventor： Takahiro Sekiguchi ,  Mikinaga Mori ,  Kentaro Numajiri ,  Hiroyuki Kitaoka

IPC: A61K9/127 ,  A61K31/7068

Abstract: An object of the present invention is to provide a liposome composition containing a liposome having an excellent leakage rate of a nucleic acid analog anticancer agent, and a method for producing the same. According to the present invention, there are provided a liposome composition containing a liposome which (1) contains a nucleic acid analog anticancer agent and in which (2) a content ratio of a lysophospholipid contained in a lipid forming the liposome with respect to a total amount of phospholipids other than the lysophospholipid contained in the lipid forming the liposome is 0.01 mol % to 5 mol % and (3) a nucleic acid analog anticancer agent/lipid ratio is 2 mass % to 10 mass %, and a method for producing the same.