公开(公告)号：US11154534B2

公开(公告)日：2021-10-26

申请号：US16448069

申请日：2019-06-21

Applicant: FUJIFILM Corporation

Inventor： Yuta Yoshino ,  Hayato Ogura ,  Mikinaga Mori ,  Taisuke Endo ,  Kentaro Numajiri ,  Ritsuko Hori

IPC: A61K31/4045 ,  A61K9/127 ,  A61K35/00

Abstract: An object of the present invention is to provide a lipid particle composition containing panobinostat or a salt thereof and exhibiting a high bone marrow-targeting capability, and a pharmaceutical composition including the lipid particle composition. According to the present invention, provided is a lipid particle composition containing panobinostat or a salt thereof, in which a lipid particle contains a phospholipid and cholesterol.

公开(公告)号：US12285525B2

公开(公告)日：2025-04-29

申请号：US17112239

申请日：2020-12-04

Applicant: FUJIFILM Corporation

Inventor： Shintaro Tanabe ,  Masahiko Yamamoto ,  Kimihiko Sato ,  Motomasa Takahashi ,  Kazuhiro Tsuna ,  Yasutaka Tasaki ,  Taisuke Endo ,  Issei Doi ,  Hirofumi Fukunaga

IPC: A61K9/127 ,  A61K9/1272 ,  A61K9/1278 ,  C07C219/06 ,  C12N15/88

Abstract: An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided. In the formula, X represents —NR1— or —O—, R1 represents a hydrogen atom, a hydrocarbon group, or the like, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group, groups in any one or more pairs among R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is equal to or greater than 1, and c+d is equal to or greater than 1.