公开(公告)号：US20140142302A1

公开(公告)日：2014-05-22

申请号：US14166105

申请日：2014-01-28

Applicant: FUJIFILM Corporation

Inventor： Hidetomo FURUYAMA ,  Hideki KURIHARA ,  Kentarou FURUYA ,  Takahiro TERAO ,  Shinichirou SEKINE ,  Daisuke NAKAGAWA

IPC: C07D471/04 ,  C07F7/10 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/4375 ,  C07D519/00 ,  C07F7/10

Abstract: A 1,5-naphthyridine derivative represented by Formula [1] (in which R1, R2, R3, R4 and R5 represent a hydrogen atom, -L-Z (in which Z represents a non-aromatic heterocyclic group or the like; and L represents a single bond or the like), or the like, R6 represents -L-Z or the like, R7 and R8 represent a hydrogen atom or the like, and Q represents an oxygen atom or the like), or a salt thereof has an excellent inhibitory activity with respect to the PI3K-AKT pathway and the Ras-Raf-MEK-ERK pathway, and is useful for treatments such as prophylactic treatments and therapeutic treatments of diseases in which the PI3K-AKT pathway and the Ras-Raf-MEK-ERK pathway are involved.

Abstract translation: 由式[1]表示的1,5-萘啶衍生物（其中R 1，R 2，R 3，R 4和R 5表示氢原子，-LZ（其中Z表示非芳香族杂环基等），L表示 单键等）等，R6表示-LZ等，R7和R8表示氢原子等，Q表示氧原子等）或其盐具有优异的抑制性 相对于PI3K-AKT途径和Ras-Raf-MEK-ERK途径的活性，可用于治疗PI3K-AKT途径和Ras-Raf-MEK-ERK的疾病的预防性治疗和治疗性治疗 涉及到途径。