1,5-NAPHTHYRIDINE DERIVATIVE OR SALT THEREOF
    1.
    发明申请
    1,5-NAPHTHYRIDINE DERIVATIVE OR SALT THEREOF 有权
    1,5-萘啶衍生物或其盐

    公开(公告)号:US20140142302A1

    公开(公告)日:2014-05-22

    申请号:US14166105

    申请日:2014-01-28

    CPC classification number: C07D471/04 A61K31/4375 C07D519/00 C07F7/10

    Abstract: A 1,5-naphthyridine derivative represented by Formula [1] (in which R1, R2, R3, R4 and R5 represent a hydrogen atom, -L-Z (in which Z represents a non-aromatic heterocyclic group or the like; and L represents a single bond or the like), or the like, R6 represents -L-Z or the like, R7 and R8 represent a hydrogen atom or the like, and Q represents an oxygen atom or the like), or a salt thereof has an excellent inhibitory activity with respect to the PI3K-AKT pathway and the Ras-Raf-MEK-ERK pathway, and is useful for treatments such as prophylactic treatments and therapeutic treatments of diseases in which the PI3K-AKT pathway and the Ras-Raf-MEK-ERK pathway are involved.

    Abstract translation: 由式[1]表示的1,5-萘啶衍生物(其中R 1,R 2,R 3,R 4和R 5表示氢原子,-LZ(其中Z表示非芳香族杂环基等),L表示 单键等)等,R6表示-LZ等,R7和R8表示氢原子等,Q表示氧原子等)或其盐具有优异的抑制性 相对于PI3K-AKT途径和Ras-Raf-MEK-ERK途径的活性,可用于治疗PI3K-AKT途径和Ras-Raf-MEK-ERK的疾病的预防性治疗和治疗性治疗 涉及到途径。

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