公开(公告)号：US20250011361A1

公开(公告)日：2025-01-09

申请号：US18885092

申请日：2024-09-13

Applicant: FUJIFILM Corporation

Inventor： Shintaro TANABE ,  Tatsuya Nitabaru ,  Masashi Yoshimura ,  Keiko Makita ,  Hirofumi Fukunaga

IPC: C07J9/00 ,  A61K9/10 ,  A61K47/14 ,  A61K47/28 ,  C12N15/113 ,  C12N15/88

Abstract: An object of the present invention is to provide a sterol compound capable of realizing an excellent nucleic acid delivery efficiency in a case of being used in a lipid composition, and to provide a lipid composition containing the sterol compound, which is allowed to realize an excellent nucleic acid delivery efficiency. According to the present invention, a compound represented by Formula (1) is provided. In the formula, R201 represents a cyclic hydrocarbon group which may be substituted with one or more substituents, where the substituent is a hydrocarbon group having 1 to 18 carbon atoms.
R102 represents (i) a hydrogen atom, (ii) a hydrocarbon group having 1 to 4 carbon atoms, which may be substituted with one or more substituents selected from OH, SH, COOH, NR106R107, N(R108)C(O)R109, or CF3, (iii) C(O)R103, or (iv) C(O)NR104R105.
The definition of each of the other symbols is as described in the present specification.

公开(公告)号：US20250017858A1

公开(公告)日：2025-01-16

申请号：US18884577

申请日：2024-09-13

Applicant: FUJIFILM Corporation

Inventor： Noriyuki Kasagi ,  Masashi Yoshimura ,  Keiko Makita ,  Shintaro Tanabe ,  Tatsuya Nitabaru

IPC: A61K9/127 ,  A61K31/7088 ,  C12N15/88

Abstract: An object of the present invention is to provide a lipid composition capable of realizing an excellent nucleic acid delivery efficiency. According to the present invention, there is provided a lipid composition containing a compound represented by Formula (1), a lipid represented by Formula (2) or a salt of the lipid, a neutral lipid, a nonionic hydrophilic polymer, and a lipid having a nucleic acid. The definition of each symbol in the formulae is as described in the present specification.