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    LIPID COMPOSITION
    1.
    发明申请
    LIPID COMPOSITION 有权

    公开(公告)号：US20220273817A1

    公开(公告)日：2022-09-01

    申请号：US17743584

    申请日：2022-05-13

    Applicant: FUJIFILM Corporation

    Inventor： Takahiro SEKIGUCHI ,  Taisuke ENDO ,  Shun KANEUMI ,  Masaki NORO ,  Shintaro TANABE ,  Masahiko YAMAMOTO

    IPC: A61K48/00 ,  A61K47/28 ,  A61K47/10 ,  A61K47/14

    Abstract: An object of the present invention is to provide a lipid composition capable of achieving excellent nucleic acid delivery for a wide variety of nucleic acids. According to the present invention, there is provided a lipid composition containing a first lipid which is a lipid represented by Formula (1) or a salt thereof, sterols, and nucleic acid, in which a ratio of the number of moles of the first lipid in the lipid composition to the number of moles of sterols in the lipid composition is 0.300 or more and less than 1.299. In the formula, X represents —NR1— or —O—, R1 represents a hydrogen atom, a hydrocarbon group, or the like, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group, groups in any one or more pairs among R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is 1 or more, and c+d is 1 or more.

    LIPID COMPOSITION
    2.
    发明申请
    LIPID COMPOSITION 有权

    公开(公告)号：US20220096381A1

    公开(公告)日：2022-03-31

    申请号：US17457793

    申请日：2021-12-06

    Applicant: FUJIFILM Corporation

    Inventor： Taisuke ENDO ,  Shun KANEUMI ,  Masaki NORO ,  Shintaro TANABE ,  Masahiko YAMAMOTO

    IPC: A61K9/127 ,  A61K31/7105 ,  A61K47/10 ,  A61K47/28 ,  A61K47/18 ,  A61K47/24

    Abstract: An object of the present invention is to provide a lipid composition making it possible to achieve excellent delivery of nucleic acids. According to the present invention, there is provided a lipid composition containing a lipid represented by Formula (1) or a salt thereof, a nonionic lipid, a lipid having a nonionic hydrophilic polymer structure, and a nucleic acid, in which the lipid composition contains or does not contain a zwitterionic lipid, and in a case where (A) represents a molar ratio in percentage of the lipid represented by Formula (1) or a salt thereof to total lipids constituting the lipid composition and (B) represents a molar ratio in percentage of the zwitterionic lipid to total lipids constituting the lipid composition, (A) and (B) satisfy 40

    COMPOUND OR SALT THEREOF AND LIPID PARTICLES
    3.
    发明申请
    COMPOUND OR SALT THEREOF AND LIPID PARTICLES 有权

    公开(公告)号：US20210085604A1

    公开(公告)日：2021-03-25

    申请号：US17112239

    申请日：2020-12-04

    Applicant: FUJIFILM Corporation

    Inventor： Shintaro TANABE ,  Masahiko YAMAMOTO ,  Kimihiko SATO ,  Motomasa TAKAHASHI ,  Kazuhiro TSUNA ,  Yasutaka TASAKI ,  Taisuki ENDO ,  Issei DOI ,  Hirofumi FUKUNAGA

    IPC: A61K9/127 ,  C12N15/88 ,  C07C219/06

    Abstract: An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided. In the formula, X represents —NR1— or —O—, R represents a hydrogen atom, a hydrocarbon group, or the like, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group, groups in any one or more pairs among R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is equal to or greater than 1, and c+d is equal to or greater than 1.

    COMPOUND AND LIPID COMPOSITION
    4.
    发明申请
    COMPOUND AND LIPID COMPOSITION 有权

    公开(公告)号：US20250011361A1

    公开(公告)日：2025-01-09

    申请号：US18885092

    申请日：2024-09-13

    Applicant: FUJIFILM Corporation

    Inventor： Shintaro TANABE ,  Tatsuya Nitabaru ,  Masashi Yoshimura ,  Keiko Makita ,  Hirofumi Fukunaga

    IPC: C07J9/00 ,  A61K9/10 ,  A61K47/14 ,  A61K47/28 ,  C12N15/113 ,  C12N15/88

    Abstract: An object of the present invention is to provide a sterol compound capable of realizing an excellent nucleic acid delivery efficiency in a case of being used in a lipid composition, and to provide a lipid composition containing the sterol compound, which is allowed to realize an excellent nucleic acid delivery efficiency. According to the present invention, a compound represented by Formula (1) is provided. In the formula, R201 represents a cyclic hydrocarbon group which may be substituted with one or more substituents, where the substituent is a hydrocarbon group having 1 to 18 carbon atoms.
    R102 represents (i) a hydrogen atom, (ii) a hydrocarbon group having 1 to 4 carbon atoms, which may be substituted with one or more substituents selected from OH, SH, COOH, NR106R107, N(R108)C(O)R109, or CF3, (iii) C(O)R103, or (iv) C(O)NR104R105.
    The definition of each of the other symbols is as described in the present specification.

    COMPOUND OR SALT THEREOF AND LIPID PARTICLES
    5.
    发明公开
    COMPOUND OR SALT THEREOF AND LIPID PARTICLES 审中-公开

    公开(公告)号：US20240315970A1

    公开(公告)日：2024-09-26

    申请号：US18443959

    申请日：2024-02-16

    Applicant: FUJIFILM Corporation

    Inventor： Shintaro TANABE ,  Masahiko YAMAMOTO ,  Kimihiko SATO ,  Motomasa TAKAHASHI ,  Kazuhiro TSUNA ,  Yasutaka TASAKI ,  Taisuke ENDO ,  Issei DOI ,  Hirofumi FUKUNAGA

    IPC: A61K9/127 ,  C07C219/06 ,  C12N15/88

    CPC classification number: A61K9/1272 ,  A61K9/1278 ,  C07C219/06 ,  C12N15/88

    Abstract: An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided.




    In the formula, X represents —NR1— or —O—, R1 represents a hydrogen atom, a hydrocarbon group, or the like, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group,



    groups in any one or more pairs among R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is equal to or greater than 1, and c+d is equal to or greater than 1.

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