公开(公告)号：US09145415B2

公开(公告)日：2015-09-29

申请号：US14516337

申请日：2014-10-16

Applicant: FUJIFILM Corporation

Inventor： Masaru Takasaki ,  Toshiaki Tsujino ,  Shintarou Tanabe ,  Megumi Ookubo ,  Kimihiko Sato ,  Atsush Hirai ,  Daisuke Terada ,  Shinsuke Inuki ,  Shinsuke Mizumoto

IPC: A61K31/505 ,  C07D471/04 ,  C07D403/12 ,  C07D401/14 ,  C07D213/74 ,  C07D401/12 ,  C07D405/12 ,  C07D239/48 ,  C07D239/49 ,  C07D409/12 ,  C07D401/06 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  A61K31/44

CPC classification number: C07D471/04 ,  A61K31/44 ,  A61K31/505 ,  C07D213/74 ,  C07D239/48 ,  C07D239/49 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The object is to provide an Fms-like tyrosine kinase 3 (FLT3) inhibitor useful as a therapeutic agent for acute myeloid leukemia (AML). A novel nitrogen-containing heterocyclic compound represented by the general formula [1] or a salt thereof is provided. The compound or a salt thereof of the present invention can be used as an active ingredient of a pharmaceutical composition for a treatment of a disease or condition relating to FLT3, such as acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL).

Abstract translation: 目的是提供可用作急性骨髓性白血病（AML）治疗剂的Fms样酪氨酸激酶3（FLT3）抑制剂。 提供了由通式[1]表示的新型含氮杂环化合物或其盐。 本发明的化合物或其盐可以用作治疗与FLT3有关的疾病或病症的药物组合物的活性成分，例如急性骨髓性白血病（AML）和急性早幼粒细胞白血病（APL）。

公开(公告)号：US09783536B2

公开(公告)日：2017-10-10

申请号：US14795568

申请日：2015-07-09

Applicant: FUJIFILM Corporation

Inventor： Hidetomo Furuyama ,  Hideki Kurihara ,  Takahiro Terao ,  Daisuke Nakagawa ,  Shintaro Tanabe ,  Takayuki Kato ,  Masahiko Yamamoto ,  Shinichiro Sekine ,  Tomoyuki Mashiko ,  Shinsuke Inuki ,  Satoshi Ueda

IPC: C07D519/00 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: A compound represented by Formula [1](in the formula, Z1 represents N, CH, or the like; X1 represents NH or the like; R1 represents a heteroaryl group or the like; each of R2, R3, and R4 represents a hydrogen atom, a halogen atom, an alkoxy group, or the like; and R5 represents a heteroaryl group or the like) or salt thereof.