公开(公告)号：US20230219932A1

公开(公告)日：2023-07-13

申请号：US18048426

申请日：2022-10-20

Applicant: FUJIFILM Corporation

Inventor： Yoshinori KANAZAWA ,  Ryo FUJIWARA ,  Kenji SHIROKANE ,  Kousuke WATANABE ,  Yuki ARAI ,  Kazuoki KOMIYAMA ,  Hiroaki TANAKA

IPC: C07D403/08 ,  C07D471/04

CPC classification number: C07D403/08 ,  C07D471/04

Abstract: There are provided a compound of Formula (1) and a labeled biological substance having the compound.





Z1 and Z2 represent a specific 6-membered ring. However, at least one of Z1 or Z2 is a benzene ring having a specific substituent at an ortho position with respect to a nitrogen atom to which L1 or L2 is bonded, or a specific nitrogen-containing 6-membered ring in which a ring-constituting atom located at the ortho position is a nitrogen atom.
R1 to R4, R11 to R13, L1, L2, and R21 represents specific groups, and n, α1, α2, and m represent specific numbers.
The compound has at least one structure represented by —(CH2—CH2—O)m-R21 on a heterocyclic ring and has at least one substituent capable of being bonded to a carboxy group or a biological substance at a specific position, and in a case where at least one of Z1 or Z2 is the specific nitrogen-containing 6-membered ring, the specific substituents may be bonded to each other to form a ring.

公开(公告)号：US20220283170A1

公开(公告)日：2022-09-08

申请号：US17742378

申请日：2022-05-11

Applicant: FUJIFILM Corporation

Inventor： Kousuke WATANABE ,  Yoshinori KANAZAWA ,  Ryo FUJIWARA ,  Kenji SHIROKANE ,  Hiroaki TANAKA ,  Yuki ARAI ,  Kazuoki KOMIYAMA

IPC: G01N33/58 ,  C09K11/06 ,  C09B23/01 ,  C09B23/06 ,  C09B23/10

Abstract: Provided are any one of the following compounds and a fluorescently labeled biological substance having this compound. R1 to R27, L11, L12, and X+ represent a specific group, and at least one of R1 to R4 represents a substituted alkyl group.
In a case where at least one of R1 to R4 is an alkyl group having a carboxy group or a substituent capable of being bonded to a biological substance, at least one of R11 to R27 is an alkyl group or an aryl group, or at least one of R1 to R4, which does not correspond to the alkyl group having a carboxy group or an alkyl group having a substituent capable of being bonded to a biological substance, is an alkyl group having a sulfoalkyl group through a single bond or a linking group.
The total of n1 to n4 is an integer of 3 or more, and m=n1+n2+n3+n4−1 is satisfied.
At least one of R1 to R4, R13, L11 or L12 in Formula (1) and at least one of R1 to R4, R24, L11, or L12 in Formula (2) have a specific substituent.

公开(公告)号：US20210072157A1

公开(公告)日：2021-03-11

申请号：US17016419

申请日：2020-09-10

Applicant: FUJIFILM Corporation

Inventor： Yuki ARAI

IPC: G01N21/64 ,  G01N21/84 ,  G02B5/20

Abstract: A fluorescence imaging device includes a display unit that displays an operation screen receiving an operation input, and the display unit displays a setting operation screen including a parameter setting field in which a parameter relating to blue shift correction for correcting shade of a sample image caused by a difference in an incidence angle of fluorescence emitted from each sample at each position where the fluorescence is incident on an optical filter is to be set.

公开(公告)号：US20230324372A1

公开(公告)日：2023-10-12

申请号：US18185450

申请日：2023-03-17

Applicant: FUJIFILM Corporation

Inventor： Yoshinobu MIURA ,  Yuki ARAI

IPC: G01N21/78 ,  B01L3/00 ,  G01N33/52

CPC classification number: G01N33/525 ,  B01L3/5023 ,  G01N21/78 ,  B01L2200/16 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0803

Abstract: An analysis device uses an analysis chip having two regions of a first region, which has a reagent reacting with a substance to be tested, and a second region, which does not have the reagent, and includes a first light source that irradiates the first region with light from a first surface side, a second light source that irradiates the second region with light from a second surface side, a first photodetector that detects first output light and that outputs a first detection signal corresponding to the first output light, a second photodetector that detects second output light and that outputs a second detection signal corresponding to the second output light, and a processor that acquires the first detection signal, acquires the second detection signal, and corrects the first detection signal with the second detection signal to derive a concentration of the substance to be tested.