公开(公告)号：US20170042812A1

公开(公告)日：2017-02-16

申请号：US15336131

申请日：2016-10-27

Applicant: FUJIFILM Corporation

Inventor： Makoto ONO ,  Kohei ONO ,  Yuuko IGARASI

IPC: A61K9/127 ,  A61K31/7068

CPC classification number: A61K9/127 ,  A61K8/14 ,  A61K9/1271 ,  A61K9/1277 ,  A61K31/7068 ,  A61K47/10 ,  A61K47/14 ,  A61K2800/10 ,  A61Q19/00 ,  B01J13/125 ,  Y10S977/773 ,  Y10S977/906 ,  Y10S977/907

Abstract: Provided is a method for producing a liposome having safety and stability. According to the present invention, it is possible to provide a method for producing a liposome, including a step of mixing an oil phase with at least one lipid dissolved in an organic solvent and a water phase and stirring an aqueous solution containing the lipids, and a step of evaporating the organic solvent from the aqueous solution containing the liposomes obtained in the stirring step, in which the organic solvent is a mixed solvent of a water-soluble organic solvent and an ester-based organic solvent.

Abstract translation: 提供一种具有安全性和稳定性的脂质体的制造方法。 根据本发明，可以提供一种生产脂质体的方法，包括将油相与溶于有机溶剂中的至少一种脂质和水相混合并搅拌含有脂质的水溶液的步骤，以及 从在搅拌步骤中得到的含有脂质体的水溶液中蒸发有机溶剂的步骤，其中有机溶剂是水溶性有机溶剂和酯类有机溶剂的混合溶剂。