公开(公告)号：US11191804B2

公开(公告)日：2021-12-07

申请号：US16960417

申请日：2018-12-28

Applicant: FUJITA ACADEMY

Inventor： Kazuhiro Sugihara ,  Naohiro Kanayama ,  Toshiaki Shibata ,  Yuichiro Onodera

IPC: A61K38/10 ,  A61K47/64 ,  A61P35/00 ,  A61P43/00 ,  C07K7/08

Abstract: An object of the present invention is to provide a peptide drug that is able to selectively induce apoptosis in target cells. The present invention is a cytocidal agent containing a fusion peptide of an endosome escape peptide and an apoptosis-inducing peptide, which consists of an amino acid sequence represented by SEQ ID NO: 1, and the said cytocidal agent as a therapeutic agent for a disease caused by abnormal proliferation of cells.

公开(公告)号：US11357819B2

公开(公告)日：2022-06-14

申请号：US16640248

申请日：2018-08-23

Applicant: FUJITA ACADEMY

Inventor： Kazuhiro Sugihara ,  Naohiro Kanayama ,  Yuichiro Onodera ,  Toshiaki Shibata ,  Michiko Fukuda ,  Motohiro Nonaka

IPC: A61K38/10 ,  A61K47/66 ,  A61P35/00

Abstract: The present invention is a cytocidal agent including a peptide consisting of an amino acid sequence represented by SEQ ID NO: 1 and a site selectively binding to a target molecule, in which the peptide consisting of an amino acid sequence represented by SEQ ID NO: 1 is a peptide exclusively consisting of L-amino acids, a peptide in which, in amino acid sequences represented by SEQ ID NO: 1, the first to the 14th amino acids are D-amino acids, and the 15th to 19th amino acids are L-amino acids, a peptide in which, in amino acid sequences represented by SEQ ID NO: 1, the first to 14th amino acids are L-amino acids, and the 15th to the 19th amino acids are D-amino acids, or a peptide exclusively consisting of D-amino acids.