公开(公告)号：US20160370342A1

公开(公告)日：2016-12-22

申请号：US15256997

申请日：2016-09-06

Applicant: Furukawa Electric Co., Ltd.

Inventor： Kenichi KIMURA ,  Jie XU ,  Ken TSUKll ,  Toru TAKAHASHI ,  Mariko MATSUNAGA

IPC: G01N33/487 ,  G01N1/14 ,  G01N21/76 ,  G01N15/14 ,  G01N21/64

Abstract: A screening apparatus for searching for a predetermined microparticle based on optical information emitted from microparticles to selectively pick up the microparticle searched for includes a measurement chip that is made of a light permeable material, the measurement chip having a well formed therein that retains a liquid including at least one microparticle, a measuring section that is configured to acquire optical information emitted by the microparticles retained in the measurement chip, an analyzing section that is configured to analyze the optical information to extract optical information associated with the microparticles retained in the well, a liquid retaining section provided on the measurement chip, a draining section that is configured to drain a liquid retained in the liquid retaining section, an introducing section that introduces a liquid into the liquid retained section, and a liquid level controlling section that controls a liquid level of the liquid retaining section.

Abstract translation: 一种用于根据从微粒发射的光学信息来选择性地拾取所搜索到的微粒的预定微粒的筛选装置，包括由透光材料制成的测量芯片，所述测量芯片具有良好的形状，其中保持包括 至少一个微粒，测量部，其被配置为获取由保留在测量芯片中的微粒发射的光学信息;分析部，其被配置为分析光学信息以提取与保留在所述阱中的微粒相关联的光学信息; 设置在测量芯片上的液体保持部分，用于排出保留在液体保持部分中的液体的排出部分，将液体引入液体保留部分的引入部分，以及控制液体液位的液位控制部分 的液体保持部 。

公开(公告)号：US20190161719A1

公开(公告)日：2019-05-30

申请号：US16262316

申请日：2019-01-30

Applicant: FURUKAWA ELECTRIC CO., LTD.

Inventor： Kenichi KIMURA ,  Ken TSUKII ,  Toru TAKAHASHI ,  Mariko MATSUNAGA ,  Jie XU

IPC: C12M1/00 ,  C12M1/32

Abstract: Provided is a liquid feeding device which can improve collection efficiency of fine particles on an individual particle basis while improvement of workability is realized.A liquid feeding device includes: an introduction portion disposed on one end portion of the liquid feeding device, and configured to introduce a liquid into a closed space; a discharge portion disposed on another end portion of the liquid feeding device, and configured to discharge the liquid supplied into the closed space; and an upper wall provided so as to oppose the upper surface of the chip, and configured to define the closed space. The upper wall has an inclined surface which is provided such that a gap formed between the inclined surface and the chip is reduced from an introduction portion side toward a discharge portion side.

公开(公告)号：US20190039070A1

公开(公告)日：2019-02-07

申请号：US16146792

申请日：2018-09-28

Applicant: Furukawa Electric Co., Ltd.

Inventor： Mariko MATSUNAGA ,  Ken TSUKll ,  Kenichi KIMURA ,  Toru TAKAHASHI ,  Jie XU

IPC: B01L3/00

Abstract: A cell accommodating chip capable of accommodating a plurality of cells includes a substrate composed of a light-transmitting material, and a plurality of wells on at least one of main faces of the substrate, the plurality of wells being capable of accommodating cells. A surface of the cell accommodating chip including the plurality of wells has a low cell adhesion property, and affinity to a specific binding material having affinity to a produced substance produced by a cell accommodated in one of the wells and/or a released substance released by the cell.

公开(公告)号：US20150177121A1

公开(公告)日：2015-06-25

申请号：US14638166

申请日：2015-03-04

Applicant: Furukawa Electric Co., Ltd.

Inventor： Toru TAKAHASHI ,  Ken Tsukii ,  Jie Xu

IPC: G01N15/14 ,  B03B13/02

CPC classification number: G01N15/1459 ,  B03B13/02 ,  G01N15/14 ,  G01N15/1404 ,  G01N2015/1006 ,  G01N2015/1415 ,  G01N2015/1481 ,  G01N2015/149

Abstract: A sample identification sorting apparatus includes an identifying unit having an optical information-measuring section that measures optical information of a sample dispersed in a liquid, and a determining section that determines whether the sample is a target sample or a non-target sample, a sorting unit including a sorting nozzle having a flow path in communication with the flow path of the identifying unit, a liquid waste-collecting section that collects by suction a liquid waste discharged from a sorting nozzle tip, and a container to collect a sorting solution containing a target sample, a moving unit and a control unit that cause the sorting nozzle and/or the collecting container to move relatively based on the optical information. The liquid waste-collecting section has a suction nozzle that sucks a liquid waste containing a non-target sample discharged from the sorting nozzle tip or containing a non-target sample or a non-sortable sample.

Abstract translation: 样本识别分类装置包括：识别单元，具有测量分散在液体中的样本的光学信息的光学信息测量部;判定部，其判定样本是目标样本还是非目标样本;分类 包括具有与所述识别单元的流路连通的流路的分拣喷嘴，通过抽吸收集从分拣喷嘴头排出的废液的废液收集部和容器，收集含有 目标样本，移动单元和控制单元，其使得分类喷嘴和/或收集容器基于光学信息相对移动。 液体废物收集部具有吸嘴，其吸收从分选喷嘴头排出的含有非目标样品或含有非目标样品或不可分类样品的废液的废液。

公开(公告)号：US20220184602A1

公开(公告)日：2022-06-16

申请号：US17425628

申请日：2020-01-23

Applicant: FURUKAWA ELECTRIC CO., LTD.

Inventor： Toru TAKAHASHI ,  Ken TSUKII ,  Kenichi KIMURA ,  Jie XU

IPC: B01L3/00 ,  G01N15/14 ,  G01N1/38

Abstract: An analyte identifying and sorting apparatus for sorting a target analyte based on an identification result of analytes dispersed in a liquid. The apparatus includes an identification unit including an analyte storage section configured to store analytes dispersed in a liquid, a pressure control section configured to feed the liquid to a flow path provided to extend downward from the analyte storage section, a light irradiation section configured to irradiate light to the analytes, an optical information measurement section measuring optical information of the analytes, and a determination section determining whether the analyte is a target analyte or a non-target analyte based on the optical information. Also included is a sorting unit that includes a sorting nozzle connected to the identification unit and sorts a sorted solution containing the target analyte to the vessel, an effluent collection section having a suction nozzle to suck and collect an effluent involving an effluent discharged from a tip of the sorting nozzle, and a collection vessel configured to collect the sorted solution containing the target analyte. A moving unit moves the sorting nozzle and/or the collection vessel, a control unit moves the sorting nozzle and/or the collection vessel based on the optical information, and a stirring unit including a stirring member in an inner space of the analyte storage section.

公开(公告)号：US20190031993A1

公开(公告)日：2019-01-31

申请号：US16146764

申请日：2018-09-28

Applicant: Furukawa Electric Co., Ltd.

Inventor： Mariko MATSUNAGA ,  Ken TSUKll ,  Kenichi KIMURA ,  Toru TAKAHASHI ,  Jie XU ,  Takayuki MATSUMOTO ,  Kohta IGARASHI

IPC: C12M1/00 ,  C12M1/32 ,  G01N33/50

Abstract: A cell accommodating chip is adapted for use in a screening apparatus for searching for a predetermined cell based on optical information emitted from a substance on the cell accommodating chip and selectively collecting the cell searched for. The cell accommodating chip includes a substrate composed of a light-transmitting material, and a plurality of wells capable of accommodating cells, the plurality of wells being provided on at least one of main faces of the substrate. A surface of the cell accommodating chip having the plurality of wells is coated with a specific polymer having a crosslinked structure.