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公开(公告)号：US08940320B2
公开(公告)日：2015-01-27
申请号：US12091925
申请日：2006-10-17
CPC分类号： A61C8/0013 , A61C8/0016
摘要： The invention relates to a dental implant, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterized in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component. The invention also relates to a method for producing a dental implant of this type and to a specific composition, which can be used to produce a coating of this type.
摘要翻译： 本发明涉及一种牙科植入物，其包括至少在植入时与硬组织和/或软组织接触的表面区域中的涂层。 为了确保涂层（二膦酸盐）中包含的活性成分被释放到周围组织中，或者以适当的速度以可控的方式在后者中起作用，其特征在于其包含双膦酸盐，各自的药学上相容的盐或 除了至少一种选自含有支链或直链，取代或未取代的饱和或部分不饱和或不饱和的C 10 -C 30烷基 - ，烯基，烷基芳基 - ，芳基 - ，环烷基 - ，烷基环烷基 - 烷基环芳基羧酸盐，磷酸盐或硫酸盐或其混合物和/或水溶性离子聚合物组分。 本发明还涉及这种类型的牙科植入物的制造方法以及可用于制造这种类型的涂层的特定组合物。
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公开(公告)号：US20110053113A1
公开(公告)日：2011-03-03
申请号：US12919678
申请日：2009-02-23
IPC分类号： A61C13/00 , B05D1/02 , B05D1/18 , A61K31/366
CPC分类号： A61L27/34 , A61K31/366 , A61K47/61
摘要： What is described is an implant that comprises a coating, at least in areas, in the implanted state in the surface areas that are at least directly in contact with skin and/or soft tissue. The implant is preferably characterized in that the coating comprises both a statin, such as simvastatin, in the hydrolyzed or unhydrolyzed form, or pharmaceutically compatible salts thereof, as well as at least one other component selected from the group consisting of branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl, alkenyl, alkylaryl, aryl, cycloalkyl, alkylcycloalkyl, alkylcycloaryl amines or mixtures thereof and/or at least one water-soluble ionic polymer component. A method for production such an implant is also described as well as a composition that can be used in such a method.
摘要翻译： 描述的是植入物，其至少在表面区域中至少在植入状态的区域中至少直接与皮肤和/或软组织接触的涂层。 优选的植入物的特征在于，所述涂层包含水解或未水解形式的他汀类药物，例如辛伐他汀，或其药学上相容的盐，以及至少一种选自支链或直链，取代的其它组分 或未取代的饱和或部分不饱和的C 10 -C 30烷基，烯基，烷基芳基，芳基，环烷基，烷基环烷基，烷基环芳基胺或其混合物和/或至少一种水溶性离子聚合物组分。 还描述了用于生产这种植入物的方法以及可以在这种方法中使用的组合物。
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公开(公告)号：US20090130177A1
公开(公告)日：2009-05-21
申请号：US12091925
申请日：2006-10-17
CPC分类号： A61C8/0013 , A61C8/0016
摘要： The invention relates to a dental implant, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterised in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component. The invention also relates to a method for producing a dental implant of this type and to a specific composition, which can be used to produce a coating of this type.
摘要翻译： 本发明涉及一种牙科植入物，其包括至少在植入时与硬组织和/或软组织接触的表面区域中的涂层。 为了确保涂层（二膦酸盐）中包含的活性成分被释放到周围组织中或者以适当速度以受控的方式在后者中起作用，其特征在于其包含双膦酸盐，各自的药学上相容的盐或 除了至少一种选自含有支链或直链，取代或未取代的饱和或部分不饱和或不饱和的C 10 -C 30烷基 - ，烯基，烷基芳基 - ，芳基 - ，环烷基 - ，烷基环烷基 - 烷基环芳基羧酸盐，磷酸盐或硫酸盐或其混合物和/或水溶性离子聚合物组分。 本发明还涉及这种类型的牙科植入物的制造方法以及可用于制造这种类型的涂层的特定组合物。
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公开(公告)号：US20080286328A1
公开(公告)日：2008-11-20
申请号：US12091902
申请日：2006-10-17
CPC分类号： A61L27/32 , A61L27/54 , A61L2300/112 , A61L2300/606
摘要： The invention relates to an implant, e.g. a stent, bone replacement material, a prosthesis, a scaffold or similar, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterised in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component. The invention also relates to a method for producing an implant of this type and to a specific composition, which can be used to produce a coating of this type.
摘要翻译： 本发明涉及植入物，例如 支架，骨置换材料，假体，支架或类似物，其包括至少在植入时与硬组织和/或软组织接触的那些表面区域中的涂层。 为了确保涂层（二膦酸盐）中包含的活性成分被释放到周围组织中，或者以适当的速度以可控的方式在后者中起作用，其特征在于其包含双膦酸盐，各自的药学上相容的盐或 除了至少一种选自含有支链或直链，取代或未取代的饱和或部分不饱和或不饱和的C 10 -C 30烷基 - ，烯基，烷基芳基 - ，芳基 - ，环烷基 - ，烷基环烷基 - 烷基环芳基羧酸盐，磷酸盐或硫酸盐或其混合物和/或水溶性离子聚合物组分。 本发明还涉及一种用于生产这种类型的植入物和特定组合物的方法，其可用于制备这种类型的涂层。
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公开(公告)号：US09050391B2
公开(公告)日：2015-06-09
申请号：US12091902
申请日：2006-10-17
CPC分类号： A61L27/32 , A61L27/54 , A61L2300/112 , A61L2300/606
摘要： The invention relates to an implant, e.g. a stent, bone replacement material, a prosthesis, a scaffold or similar, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterized in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component. The invention also relates to a method for producing an implant of this type and to a specific composition, which can be used to produce a coating of this type.
摘要翻译： 本发明涉及植入物，例如 支架，骨置换材料，假体，支架或类似物，其包括至少在植入时与硬组织和/或软组织接触的那些表面区域中的涂层。 为了确保涂层（二膦酸盐）中包含的活性成分被释放到周围组织中，或者以适当的速度以可控的方式在后者中起作用，其特征在于其包含双膦酸盐，各自的药学上相容的盐或 除了至少一种选自含有支链或直链，取代或未取代的饱和或部分不饱和或不饱和的C 10 -C 30烷基 - ，烯基，烷基芳基 - ，芳基 - ，环烷基 - ，烷基环烷基 - 烷基环芳基羧酸盐，磷酸盐或硫酸盐或其混合物和/或水溶性离子聚合物组分。 本发明还涉及一种用于生产这种类型的植入物和特定组合物的方法，其可用于制备这种类型的涂层。
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公开(公告)号：US08414958B2
公开(公告)日：2013-04-09
申请号：US12919678
申请日：2009-02-23
IPC分类号： A61L33/00
CPC分类号： A61L27/34 , A61K31/366 , A61K47/61
摘要： What is described is an implant that comprises a coating, at least in areas, in the implanted state in the surface areas that are at least directly in contact with skin and/or soft tissue. The implant is preferably characterized in that the coating comprises both a statin, such as simvastatin, in the hydrolyzed or unhydrolyzed form, or pharmaceutically compatible salts thereof, as well as at least one other component selected from the group consisting of branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl, alkenyl, alkylaryl, aryl, cycloalkyl, alkylcycloalkyl, alkylcycloaryl amines or mixtures thereof and/or at least one water-soluble ionic polymer component. A method for production such an implant is also described as well as a composition that can be used in such a method.
摘要翻译： 描述的是植入物，其至少在表面区域中至少在植入状态的区域中至少直接与皮肤和/或软组织接触的涂层。 优选的植入物的特征在于，所述涂层包含水解或未水解形式的他汀类药物，例如辛伐他汀，或其药学上相容的盐，以及至少一种选自支链或直链，取代的其它组分 或未取代的饱和或部分不饱和的C 10 -C 30烷基，烯基，烷基芳基，芳基，环烷基，烷基环烷基，烷基环芳基胺或其混合物和/或至少一种水溶性离子聚合物组分。 还描述了用于生产这种植入物的方法以及可以在这种方法中使用的组合物。
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