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    Methods for Treating Kidney Disorders
    4.
    发明申请
    Methods for Treating Kidney Disorders 审中-公开
    肾脏疾病治疗方法

    公开(公告)号：US20080206243A1

    公开(公告)日：2008-08-28

    申请号：US12110042

    申请日：2008-04-25

    申请人： Megan Baldwin ,  Hans-Peter Gerber ,  Napoleone Ferrara

    发明人： Megan Baldwin ,  Hans-Peter Gerber ,  Napoleone Ferrara

    IPC分类号： A61K39/395 ,  A61K38/18

    CPC分类号： C07K16/22 ,  A61K38/1866 ,  A61K38/1891

    摘要： Provided are methods of treating kidney disorders in a subject by administering an effective amount of VEGFR agonist, e.g., a Flt1 agonist to a subject. The agonists are composed of compositions comprising VEGFR agonists, e.g., VEGF, antibodies directed to Flt1, Flt1 ligands, Flt1 small molecule activators, or Flt1 selective agents in a pharmaceutically acceptable carrier for use in activating Flt1.

    摘要翻译： 提供了通过向受试者施用有效量的VEGFR激动剂例如Flt1激动剂来治疗受试者的肾脏疾病的方法。 激动剂由包含VEGFR激动剂例如VEGF，针对用于激活Flt1的药学上可接受的载体中的Flt1，Flt1配体，Flt1小分子激活剂或Flt1选择剂的抗体组成。

    METHODS FOR TREATING KIDNEY DISORDERS
    5.
    发明申请
    METHODS FOR TREATING KIDNEY DISORDERS 审中-公开
    治疗恶心病的方法

    公开(公告)号：US20070264259A1

    公开(公告)日：2007-11-15

    申请号：US11691465

    申请日：2007-03-26

    申请人： Megan Baldwin ,  Hans-Peter Gerber ,  Napoleone Ferrara

    发明人： Megan Baldwin ,  Hans-Peter Gerber ,  Napoleone Ferrara

    IPC分类号： A61K39/395 ,  A61K38/18 ,  A61P43/00 ,  A61K39/00

    CPC分类号： C07K16/22 ,  A61K38/1866 ,  A61K38/1891

    摘要： Provided are methods of treating kidney disorders in a subject by administering an effective amount of VEGFR agonist, e.g., a Flt1 agonist to a subject. The agonists are composed of compositions comprising VEGFR agonists, e.g., VEGF, antibodies directed to Flt1, Flt1 ligands, Flt1 small molecule activators, or Flt1 selective agents in a pharmaceutically acceptable carrier for use in activating Flt1.

    摘要翻译： 提供了通过向受试者施用有效量的VEGFR激动剂例如Flt1激动剂来治疗受试者的肾脏疾病的方法。 激动剂由包含VEGFR激动剂例如VEGF，针对用于激活Flt1的药学上可接受的载体中的Flt1，Flt1配体，Flt1小分子激活剂或Flt1选择剂的抗体组成。

    Methods and compositions for activating or inhibiting vegf-d and vegf-c
    6.
    发明申请
    Methods and compositions for activating or inhibiting vegf-d and vegf-c 失效
    激活或抑制vegf-d和vegf-c的方法和组合物

    公开(公告)号：US20050282228A1

    公开(公告)日：2005-12-22

    申请号：US10522232

    申请日：2003-07-21

    申请人： Bradley Mccoll ,  Megan Baldwin ,  Steven Stacker ,  Narc Achen

    发明人： Bradley Mccoll ,  Megan Baldwin ,  Steven Stacker ,  Narc Achen

    IPC分类号： A61K38/48 ,  C07K16/22 ,  C12Q1/37 ,  G01N33/53

    CPC分类号： A61K38/484 ,  A61K2039/505 ,  C07K16/22 ,  C12Q1/37 ,  G01N2333/475 ,  G01N2333/71 ,  G01N2333/96433 ,  G01N2500/02 ,  G01N2500/04

    摘要： Methods for activating endothelial growth factors VEGF-C or VEGF-D with plasmin, and methods of treatment comprising administering a phamarceutical compositions comprising plasmin. Also disclosed are methods for screening for inhibitors of activation of the growth factors by plasmin, and method of treatment by blocking activation of VEGF-C/D activation by plasmin. Further disclosed are methods for screening for other proteases that activate VEGF-C/D, and for inhibitors of such activation. The invention further includes inhibitors of plasmin activity and methods of treating patients in need thereof with said inhibitors.

    摘要翻译： 用纤溶酶激活内皮生长因子VEGF-C或VEGF-D的方法和治疗方法包括施用包含纤溶酶的络合物组合物。 还公开了用于筛选纤溶酶激活生长因子抑制剂的方法，以及通过阻断纤溶酶的VEGF-C / D活化激活的方法。 进一步公开的是筛选其它激活VEGF-C / D的蛋白酶的方法，以及用于这种活化抑制剂的方法。 本发明还包括纤溶酶活性抑制剂和用所述抑制剂治疗有需要的患者的方法。