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公开(公告)号：US20070264193A1
公开(公告)日：2007-11-15
申请号：US11692681
申请日：2007-03-28
IPC分类号： A61K39/395 , A61B5/00 , C12Q1/06
CPC分类号： G01N33/57492 , A61K2039/507 , C07K16/22 , C07K16/28
摘要： Methods for the treatment of cancer with combination therapies that include anti-VEGF antibodies are provided. Methods for diagnosing resistant tumors are also provided.
摘要翻译： 提供了包括抗VEGF抗体的组合疗法治疗癌症的方法。 还提供了诊断耐药性肿瘤的方法。
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公开(公告)号：US20100239568A1
公开(公告)日：2010-09-23
申请号：US12769004
申请日：2010-04-28
IPC分类号： A61K39/395 , C12Q1/02 , A61K31/7068 , A61P35/00 , A61K31/505
CPC分类号： G01N33/57492 , A61K2039/507 , C07K16/22 , C07K16/28
摘要： Methods for the treatment of cancer with combination therapies that include anti-VEGF antibodies are provided. Methods for diagnosing resistant tumors are also provided.
摘要翻译： 提供了包括抗VEGF抗体的组合疗法治疗癌症的方法。 还提供了诊断耐药性肿瘤的方法。
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公开(公告)号：US20070250941A1
公开(公告)日：2007-10-25
申请号：US11691469
申请日：2007-03-26
IPC分类号： A01K67/027 , C12N5/06 , C07K14/71
CPC分类号： C07K14/71 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509 , C12N2800/30 , C12N2830/008
摘要： Transgenic non-human animals and methods of producing non-human transgenic animals comprising within their genome a conditional targeted mutation in a VEGFR, e.g., VEGFR1 or VEGFR2, gene are provided along with methods and vectors used to produce such animals or cells.
摘要翻译： 提供转基因非人动物以及在其基因组中包含VEGFR1（VEGFR1或VEGFR2）基因中的条件靶向突变的非人转基因动物的生产方法以及用于产生这种动物或细胞的方法和载体。
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公开(公告)号：US20080206243A1
公开(公告)日：2008-08-28
申请号：US12110042
申请日：2008-04-25
IPC分类号： A61K39/395 , A61K38/18
CPC分类号： C07K16/22 , A61K38/1866 , A61K38/1891
摘要： Provided are methods of treating kidney disorders in a subject by administering an effective amount of VEGFR agonist, e.g., a Flt1 agonist to a subject. The agonists are composed of compositions comprising VEGFR agonists, e.g., VEGF, antibodies directed to Flt1, Flt1 ligands, Flt1 small molecule activators, or Flt1 selective agents in a pharmaceutically acceptable carrier for use in activating Flt1.
摘要翻译： 提供了通过向受试者施用有效量的VEGFR激动剂例如Flt1激动剂来治疗受试者的肾脏疾病的方法。 激动剂由包含VEGFR激动剂例如VEGF，针对用于激活Flt1的药学上可接受的载体中的Flt1，Flt1配体，Flt1小分子激活剂或Flt1选择剂的抗体组成。
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公开(公告)号：US20070264259A1
公开(公告)日：2007-11-15
申请号：US11691465
申请日：2007-03-26
IPC分类号： A61K39/395 , A61K38/18 , A61P43/00 , A61K39/00
CPC分类号： C07K16/22 , A61K38/1866 , A61K38/1891
摘要： Provided are methods of treating kidney disorders in a subject by administering an effective amount of VEGFR agonist, e.g., a Flt1 agonist to a subject. The agonists are composed of compositions comprising VEGFR agonists, e.g., VEGF, antibodies directed to Flt1, Flt1 ligands, Flt1 small molecule activators, or Flt1 selective agents in a pharmaceutically acceptable carrier for use in activating Flt1.
摘要翻译： 提供了通过向受试者施用有效量的VEGFR激动剂例如Flt1激动剂来治疗受试者的肾脏疾病的方法。 激动剂由包含VEGFR激动剂例如VEGF，针对用于激活Flt1的药学上可接受的载体中的Flt1，Flt1配体，Flt1小分子激活剂或Flt1选择剂的抗体组成。
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6.发明授权Composition comprising and method of using angiopoietin-like protein 3 ANGPTL3 有权组合物和使用血管生成素样蛋白3 ANGPTL3的方法公开(公告)号：US08541376B2
公开(公告)日：2013-09-24
申请号：US12128545
申请日：2008-05-28
申请人： Napoleone Ferrara , Hans-Peter Gerber , Joe Kowalski , Maria Teresa Pisabarro , Daniel Eric Sherman
发明人： Napoleone Ferrara , Hans-Peter Gerber , Joe Kowalski , Maria Teresa Pisabarro , Daniel Eric Sherman
CPC分类号： C07K14/515 , A61K48/00 , C12N2799/022
摘要： The present invention is directed to methods and means for making and using Angptl3 polypeptides. The invention specifically concerns the use of Angptl3 polypeptides in inducing liver regeneration and angiogenesis. Further methods include the use of Angptl3 polypeptides in the diagnosis and treatment of liver disease. Also provided herein are antibodies which bind to the polypeptides of the present invention.
摘要翻译： 本发明涉及制备和使用Angpt13多肽的方法和手段。 本发明特别涉及Angpt3多肽在诱导肝再生和血管发生中的应用。 其他方法包括使用Angpt3多肽来诊断和治疗肝脏疾病。 本文还提供结合本发明多肽的抗体。
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7.发明申请Composition Comprising and Method of Using Angiopoietin-Like Protein 3 ANGPTL3 审中-公开使用促生长素样蛋白3的组合物和方法ANGPTL3公开(公告)号：US20070134250A1
公开(公告)日：2007-06-14
申请号：US11537567
申请日：2006-09-29
IPC分类号： A61K39/395 , C12Q1/68 , A61K38/55
CPC分类号： C07K14/515 , A61K48/00 , C12N2799/022
摘要： The present invention is directed to methods and means for making and using Angpt13 polypeptides. The invention specifically concerns the use of Angpt13 polypeptides in inducing liver regeneration and angiogenesis. Further methods include the use of Angpt13 polypeptides in the diagnosis and treatment of liver disease. Also provided herein are antibodies which bind to the polypeptides of the present invention.
摘要翻译： 本发明涉及制备和使用Angpt13多肽的方法和手段。 本发明具体涉及Angpt13多肽在诱导肝脏再生和血管生成中的应用。 其他方法包括在诊断和治疗肝脏疾病中使用Angpt13多肽。 本文还提供结合本发明多肽的抗体。
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8.发明授权Composition comprising and method of using angiopoietin-like protein 3 Angptl3 有权组合物和使用血管生成素样蛋白3 Angpt13的方法公开(公告)号：US07267819B2
公开(公告)日：2007-09-11
申请号：US10298461
申请日：2002-11-15
申请人： Napoleone Ferrara , Hans-Peter Gerber , Joe Kowalski , Maria Teresa Pisabarro , Daniel Eric Sherman
发明人： Napoleone Ferrara , Hans-Peter Gerber , Joe Kowalski , Maria Teresa Pisabarro , Daniel Eric Sherman
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K14/515 , A61K48/00 , C12N2799/022
摘要： The present invention is directed to methods and means for making and using Angptl3 polypeptides. The invention specifically concerns the use of Angptl3 polypeptides in inducing liver regeneration and angiogenesis. Further methods include the use of Angptl3 polypeptides in the diagnosis and treatment of liver disease. Also provided herein are antibodies which bind to the polypeptides of the present invention.
摘要翻译： 本发明涉及制备和使用Angpt13多肽的方法和手段。 本发明特别涉及Angpt3多肽在诱导肝再生和血管发生中的应用。 其他方法包括使用Angpt3多肽来诊断和治疗肝脏疾病。 本文还提供结合本发明多肽的抗体。
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公开(公告)号：US20100316652A1
公开(公告)日：2010-12-16
申请号：US12861741
申请日：2010-08-23
申请人： Napoleone Ferrara , Kyung Jin Kim
发明人： Napoleone Ferrara , Kyung Jin Kim
IPC分类号： A61K39/395 , A61P27/02
CPC分类号： C07K16/22 , A61K38/179 , A61K38/1866 , A61K2039/505 , C07K14/475 , C07K16/2863 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention provides human vascular endothelial cell growth factor (hVEGF) antagonists, including monoclonal antibodies, hVEGF receptors, and hVEGF variants that are useful for the treatment of age-related macular degeneration, and other diseases and disorders characterized by undesirable or excessive neovascularization.
摘要翻译： 本发明提供了人类血管内皮细胞生长因子（hVEGF）拮抗剂，包括可用于治疗年龄相关性黄斑变性的单克隆抗体，hVEGF受体和hVEGF变体以及以不良或过度新生血管形成为特征的其它疾病和病症。
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公开(公告)号：US07727536B2
公开(公告)日：2010-06-01
申请号：US11537382
申请日：2006-09-29
CPC分类号： C07K14/52 , A61K38/1866 , C07K14/475 , G01N33/74 , G01N2333/515 , G01N2500/04
摘要： The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
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