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公开(公告)号：US20060276491A9
公开(公告)日：2006-12-07
申请号：US10715773
申请日：2003-11-17
申请人： Fatih Uckun , Elise Sudbeck , Marina Cetkovic , Ravi Malaviya , Xing-Ping Liu
发明人： Fatih Uckun , Elise Sudbeck , Marina Cetkovic , Ravi Malaviya , Xing-Ping Liu
IPC分类号： A61K31/517 , C07D239/72
CPC分类号： A61K31/00 , A61K31/505 , A61K31/517 , C07D239/74 , C07D239/94
摘要： The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.
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公开(公告)号：US06495556B2
公开(公告)日：2002-12-17
申请号：US09812098
申请日：2001-03-19
IPC分类号： A61K3152
CPC分类号： A61K31/00 , A61K31/505 , A61K31/517 , C07D239/74 , C07D239/94
摘要： The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.
摘要翻译： 本发明提供了可用于治疗白血病和淋巴瘤的新型JAK-3抑制剂。 这些化合物也可用于治疗或预防皮肤癌，以及晒伤和UVB诱导的皮肤炎症。 此外，本发明的化合物可防止UVB辐射的免疫抑制作用，并且可用于治疗或预防自身免疫性疾病，炎症和移植排斥。 本发明还提供了包含本发明化合物的药物组合物，以及它们使用的治疗方法。
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公开(公告)号：US06469013B2
公开(公告)日：2002-10-22
申请号：US09858824
申请日：2001-05-16
IPC分类号： A61K31517
CPC分类号： A61K31/00 , A61K31/505 , A61K31/517 , C07D239/74 , C07D239/94
摘要： The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.
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公开(公告)号：US06313129B1
公开(公告)日：2001-11-06
申请号：US09378093
申请日：1999-08-20
IPC分类号： A61K31517
CPC分类号： A61K31/00 , A61K31/505 , A61K31/517 , C07D239/74 , C07D239/94
摘要： The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.
摘要翻译： 本发明提供了可用于治疗白血病和淋巴瘤的新型JAK-3抑制剂。 这些化合物也可用于治疗或预防皮肤癌，以及晒伤和UVB诱导的皮肤炎症。 此外，本发明的化合物可防止UVB辐射的免疫抑制作用，并且可用于治疗或预防自身免疫性疾病，炎症和移植排斥。 本发明还提供了包含本发明化合物的药物组合物，以及它们使用的治疗方法。
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