公开(公告)号：US20060129139A1

公开(公告)日：2006-06-15

申请号：US11353842

申请日：2006-02-14

申请人： Felix Theeuwes ,  Ben Eckenhoff ,  Bonnie Dennis

发明人： Felix Theeuwes ,  Ben Eckenhoff ,  Bonnie Dennis

IPC分类号： A61K9/22

CPC分类号： A61K9/0004

摘要： An osmotic delivery system having a space-efficient piston is provided. The enclosure has an interior holding the piston, a protein or polypeptide, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmopolymer from the protein or polypeptide. The piston has a recess that receives at least a portion of the osmotic agent. The osmotic agent imbibes liquid from a surrounding environment to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.

摘要翻译： 提供了具有节省空间的活塞的渗透输送系统。 外壳具有保持活塞，蛋白质或多肽和渗透剂的内部。 活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。 可移动密封将渗透聚合物与蛋白质或多肽分开。 活塞具有容纳渗透剂的至少一部分的凹部。 渗透剂吸收来自周围环境的液体以使活塞移动，从而导致有益剂从胶囊的输送。

公开(公告)号：US20070203476A1

公开(公告)日：2007-08-30

申请号：US11743185

申请日：2007-05-02

申请人： Felix Theeuwes ,  Ben Eckenhoff ,  Bonnie Dennis

发明人： Felix Theeuwes ,  Ben Eckenhoff ,  Bonnie Dennis

IPC分类号： A61K9/22

CPC分类号： A61K9/0004

摘要： An osmotic delivery system having a space-efficient piston is provided. The enclosure has an interior holding the piston, a protein or polypeptide, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmopolymer from the protein or peptide. The piston has a recess that receives at least a portion of the osmotic agent. The osmotic agent imbibes liquid from a surrounding environment to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.

摘要翻译： 提供了具有节省空间的活塞的渗透输送系统。 外壳具有保持活塞，蛋白质或多肽和渗透剂的内部。 活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。 可移动密封将渗透聚合物与蛋白质或肽分离。 活塞具有容纳渗透剂的至少一部分的凹部。 渗透剂吸收来自周围环境的液体以使活塞移动，从而导致有益剂从胶囊的输送。

公开(公告)号：US20050085797A1

公开(公告)日：2005-04-21

申请号：US10959489

申请日：2004-10-05

申请人： Felix Theeuwes ,  Ben Eckenhoff ,  Bonnie Dennis

发明人： Felix Theeuwes ,  Ben Eckenhoff ,  Bonnie Dennis

IPC分类号： A61M37/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/52 ,  A61M1/14 ,  A61M1/16

CPC分类号： A61K9/0004

摘要： An osmotic delivery system having a space-efficient piston is provided. The enclosure has an interior holding the piston, a beneficial agent, and an osmopolymer including a tablet. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmopolymer from the beneficial agent. The piston has a recess that receives at least a portion of the osmopolymer. The osmopolymer imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.

摘要翻译： 提供了具有节省空间的活塞的渗透输送系统。 外壳具有保持活塞的内部，有益剂和包含片剂的渗透聚合物。 活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。 可移动密封件将渗透聚合物与有益剂分离。 活塞具有容纳至少一部分渗透聚合物的凹部。 渗透聚合物通过半透水体吸收来自周围环境的液体，以引起活塞移动，从而导致有益剂从胶囊的输送。

公开(公告)号：US06544252B1

公开(公告)日：2003-04-08

申请号：US09472600

申请日：1999-12-27

申请人： Felix Theeuwes ,  Ben Eckenhoff

发明人： Felix Theeuwes ,  Ben Eckenhoff

IPC分类号： A61K922

CPC分类号： A61K9/0004

摘要： An osmotic delivery system having a space efficient piston. The capsule has an interior holding the piston, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The moveable seal separates the osmotic agent from the beneficial agent. The piston has a recess that receives at least a portion of the osmotic agent. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.

摘要翻译： 具有空间高效活塞的渗透输送系统。 胶囊具有保持活塞的内部，有益剂和渗透剂。 活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。 可移动密封件将渗透剂与有益剂分离。 活塞具有容纳渗透剂的至少一部分的凹部。 渗透剂通过半透水体吸收来自周围环境的液体，引起活塞移动，从而导致有益剂从胶囊的输送。

公开(公告)号：US06872201B2

公开(公告)日：2005-03-29

申请号：US10354142

申请日：2003-01-30

申请人： Felix Theeuwes ,  Bonnie Burdett Dennis

发明人： Ben Eckenhoff

IPC分类号： A61M37/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/52 ,  A61M1/14 ,  A61M1/16 ,  A61K13/00

CPC分类号： A61K9/0004

摘要： An osmotic delivery system having a space-efficient piston is provided. The enclosure has an interior holding the position, a beneficial agent, and an osmotic agent including a tablet. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a recess that receives at least a portion of the osmotic agent. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.

摘要翻译： 提供了具有节省空间的活塞的渗透输送系统。 外壳具有保持该位置的内部，有益剂和包含片剂的渗透剂。 活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。 可移动密封件将渗透剂与有益剂分离。 活塞具有容纳渗透剂的至少一部分的凹部。 渗透剂通过半透水体吸收来自周围环境的液体，引起活塞移动，从而导致有益剂从胶囊的输送。