公开(公告)号：US20060129139A1

公开(公告)日：2006-06-15

申请号：US11353842

申请日：2006-02-14

申请人： Felix Theeuwes ,  Ben Eckenhoff ,  Bonnie Dennis

发明人： Felix Theeuwes ,  Ben Eckenhoff ,  Bonnie Dennis

IPC分类号： A61K9/22

CPC分类号： A61K9/0004

摘要： An osmotic delivery system having a space-efficient piston is provided. The enclosure has an interior holding the piston, a protein or polypeptide, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmopolymer from the protein or polypeptide. The piston has a recess that receives at least a portion of the osmotic agent. The osmotic agent imbibes liquid from a surrounding environment to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.

摘要翻译： 提供了具有节省空间的活塞的渗透输送系统。 外壳具有保持活塞，蛋白质或多肽和渗透剂的内部。 活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。 可移动密封将渗透聚合物与蛋白质或多肽分开。 活塞具有容纳渗透剂的至少一部分的凹部。 渗透剂吸收来自周围环境的液体以使活塞移动，从而导致有益剂从胶囊的输送。

公开(公告)号：US06544252B1

公开(公告)日：2003-04-08

申请号：US09472600

申请日：1999-12-27

申请人： Felix Theeuwes ,  Ben Eckenhoff

发明人： Felix Theeuwes ,  Ben Eckenhoff

IPC分类号： A61K922

CPC分类号： A61K9/0004

摘要： An osmotic delivery system having a space efficient piston. The capsule has an interior holding the piston, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The moveable seal separates the osmotic agent from the beneficial agent. The piston has a recess that receives at least a portion of the osmotic agent. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.

摘要翻译： 具有空间高效活塞的渗透输送系统。 胶囊具有保持活塞的内部，有益剂和渗透剂。 活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。 可移动密封件将渗透剂与有益剂分离。 活塞具有容纳渗透剂的至少一部分的凹部。 渗透剂通过半透水体吸收来自周围环境的液体，引起活塞移动，从而导致有益剂从胶囊的输送。

公开(公告)号：US20070203476A1

公开(公告)日：2007-08-30

申请号：US11743185

申请日：2007-05-02

申请人： Felix Theeuwes ,  Ben Eckenhoff ,  Bonnie Dennis

发明人： Felix Theeuwes ,  Ben Eckenhoff ,  Bonnie Dennis

IPC分类号： A61K9/22

CPC分类号： A61K9/0004

摘要： An osmotic delivery system having a space-efficient piston is provided. The enclosure has an interior holding the piston, a protein or polypeptide, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmopolymer from the protein or peptide. The piston has a recess that receives at least a portion of the osmotic agent. The osmotic agent imbibes liquid from a surrounding environment to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.

摘要翻译： 提供了具有节省空间的活塞的渗透输送系统。 外壳具有保持活塞，蛋白质或多肽和渗透剂的内部。 活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。 可移动密封将渗透聚合物与蛋白质或肽分离。 活塞具有容纳渗透剂的至少一部分的凹部。 渗透剂吸收来自周围环境的液体以使活塞移动，从而导致有益剂从胶囊的输送。

公开(公告)号：US20050085797A1

公开(公告)日：2005-04-21

申请号：US10959489

申请日：2004-10-05

申请人： Felix Theeuwes ,  Ben Eckenhoff ,  Bonnie Dennis

发明人： Felix Theeuwes ,  Ben Eckenhoff ,  Bonnie Dennis

IPC分类号： A61M37/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/52 ,  A61M1/14 ,  A61M1/16

CPC分类号： A61K9/0004

摘要： An osmotic delivery system having a space-efficient piston is provided. The enclosure has an interior holding the piston, a beneficial agent, and an osmopolymer including a tablet. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmopolymer from the beneficial agent. The piston has a recess that receives at least a portion of the osmopolymer. The osmopolymer imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.

摘要翻译： 提供了具有节省空间的活塞的渗透输送系统。 外壳具有保持活塞的内部，有益剂和包含片剂的渗透聚合物。 活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。 可移动密封件将渗透聚合物与有益剂分离。 活塞具有容纳至少一部分渗透聚合物的凹部。 渗透聚合物通过半透水体吸收来自周围环境的液体，以引起活塞移动，从而导致有益剂从胶囊的输送。

公开(公告)号：US20130028953A1

公开(公告)日：2013-01-31

申请号：US13486711

申请日：2012-06-01

申请人： Su II Yum ,  Felix Theeuwes

发明人： Su II Yum ,  Felix Theeuwes

IPC分类号： A61K9/70 ,  A61P29/00 ,  A61K31/4535

CPC分类号： A61K9/703 ,  A61F2013/0296 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7084 ,  A61K31/445 ,  A61K31/4535 ,  A61M35/00

摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.

摘要翻译： 提供了通过皮肤施用舒芬太尼的透皮递送系统。 当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。 该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂， 优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。 还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。

公开(公告)号：US08246977B2

公开(公告)日：2012-08-21

申请号：US11665813

申请日：2005-10-21

申请人： Su Il Yum ,  Felix Theeuwes

发明人： Su Il Yum ,  Felix Theeuwes

IPC分类号： A61K9/70 ,  A61K31/445

CPC分类号： A61K9/703 ,  A61F2013/0296 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7084 ,  A61K31/445 ,  A61K31/4535 ,  A61M35/00

摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.

摘要翻译： 提供了通过皮肤施用舒芬太尼的透皮递送系统。 当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。 该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂， 优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。 还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。

公开(公告)号：US20100016267A1

公开(公告)日：2010-01-21

申请号：US10592886

申请日：2005-03-15

申请人： Felix Theeuwes ,  Arthur J. Tipton

发明人： Felix Theeuwes ,  Arthur J. Tipton

IPC分类号： A61K31/58 ,  A61P27/00

CPC分类号： A61K9/0043

摘要： Pharmaceutical compositions for delivering a drug to a sinus in a subject are provided. The compositions are formed by the combination of a carrier material and a drug and are specially adapted for delivery to a sinus. The compositions have no fixed shape, and the carrier material serves to increase the viscosity or specific volume of the composition after introduction of the composition into the sinus. Also provided are methods for delivering a drug to a subject. The methods entail administering a pharmaceutical composition according to the present invention directly to a sinus. The drug is then released from the composition to the sinus. The pharmaceutical compositions can be administered to a sinus in liquid form, for example, as a suspension or solution using standard techniques. Also provided is the use of a carrier material in the manufacture of a drug delivery composition. The drug delivery composition is for delivering a drug to a sinus in a subject. The composition comprises the carrier material combined with the drug to be delivered, and has no fixed shape. After the composition is introduced into a sinus, the carrier material serves to increase the viscosity or specific volume of the composition.

摘要翻译： 提供用于将药物递送至受试者的窦的药物组合物。 组合物通过载体材料和药物的组合形成，并且特别适于递送至窦。 组合物没有固定的形状，并且载体材料用于在将组合物引入窦内后增加组合物的粘度或比体积。 还提供了将药物递送到受试者的方法。 所述方法需要将根据本发明的药物组合物直接给予鼻窦。 然后将药物从组合物释放到窦。 药物组合物可以以液体形式施用于窦，例如使用标准技术作为悬浮液或溶液施用。 还提供了载体材料在制备药物递送组合物中的用途。 药物递送组合物用于将药物递送至受试者的窦。 该组合物包含与待输送药物结合的载体材料，并且不具有固定形状。 在将组合物引入窦中之后，载体材料用于增加组合物的粘度或比体积。

公开(公告)号：US20080260811A1

公开(公告)日：2008-10-23

申请号：US11888661

申请日：2007-07-31

申请人： Su Il Yum ,  Felix Theeuwes

发明人： Su Il Yum ,  Felix Theeuwes

IPC分类号： A61K31/4436 ,  A61K9/70 ,  A61P43/00

CPC分类号： A61K31/4535 ,  A61F2013/0296 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7084

摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.

摘要翻译： 提供了通过皮肤施用舒芬太尼的透皮递送系统。 当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。 该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂， 优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。 还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。

公开(公告)号：US20080175890A1

公开(公告)日：2008-07-24

申请号：US11888650

申请日：2007-07-31

申请人： Su Il Yum ,  Felix Theeuwes

发明人： Su Il Yum ,  Felix Theeuwes

IPC分类号： A61K31/4535 ,  A61K9/70 ,  A61P31/00

CPC分类号： A61K31/4535 ,  A61F2013/0296 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7084

摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.

公开(公告)号：US20070167932A1

公开(公告)日：2007-07-19

申请号：US11726517

申请日：2007-03-21

申请人： Felix Theeuwes ,  Su Yum

发明人： Felix Theeuwes ,  Su Yum

IPC分类号： A61K9/22

CPC分类号： A61M25/00 ,  A61M25/0043 ,  A61M2025/0057 ,  A61M2025/105 ,  A61M2025/1086

摘要： The invention provides a local concentration management system (LCMS) for delivery of highly concentrated therapeutic agent formulations. The LCMS comprises a device comprising an elongate body defining a lumen between its proximal and distal ends, and a diffuser element, a dilutor element, or both. The diffuser element, which is selectively permeable to the agent, is operatively associated with the elongate body so that agent flows through the elongate body, and into and through the diffuser element to exit the system. The dilutor element can be operatively associated with the system to be in fluid communication with the elongate body lumen, a diffusion space defined by a diffuser element inner wall, or both. The dilutor element is selectively water permeable, but substantially impermeable to agent, to provide for dilution of the agent during transit through the system. The LCMS system is designed to disperse and/or dilute the drug delivery stream.

摘要翻译： 本发明提供了用于递送高度浓缩的治疗剂制剂的局部浓度管理系统（LCMS）。 LCMS包括装置，其包括在其近端和远端之间限定内腔的细长主体，以及扩散器元件，稀释元件或两者。 对试剂选择性渗透的扩散器元件可与细长体可操作地连接，使得试剂流过细长体并进入并通过扩散器元件以离开系统。 稀释元件可以与系统可操作地相关联以与细长体腔流体连通，由扩散器元件内壁或两者限定的扩散空间。 稀释剂元件选择性地是水可渗透的，但是对试剂基本上是不可渗透的，以便在通过系统运输期间提供试剂的稀释。 LCMS系统被设计成分散和/或稀释药物输送流。