公开(公告)号：US5250028A

公开(公告)日：1993-10-05

申请号：US741477

申请日：1991-08-09

申请人： Felix Theeuwes ,  Su I. Yum

发明人： Felix Theeuwes ,  Su I. Yum

IPC分类号： A61M5/14 ,  A61M37/00

CPC分类号： A61M5/1407

摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a material which is permeable to the drug but which prevents convective loss of the IV fluid. A transdermal-type drug delivery device is adhered to the semipermeable/microporous wall portion. Drug is delivered by the delivery device through the wall portion using permeation enhancers and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the wall portion or a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the wall portion to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate.

摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。 室壁的一部分由药物可渗透的材料组成，但是防止IV流体的对流损失。 透皮型药物输送装置粘附在半透膜/微孔壁部分上。 药物由输送装置通过使用渗透促进剂的壁部分输送到流动的IV流体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 从装置向IV流体的药物递送速率由药物递送装置中的壁部分或膜层控制。 多个药物递送装置可以粘附到壁部分以递送多种药物或以更高的剂量率递送单一药物。

公开(公告)号：US4985016A

公开(公告)日：1991-01-15

申请号：US311905

申请日：1989-02-15

申请人： Felix Theeuwes ,  Su I. Yum

发明人： Felix Theeuwes ,  Su I. Yum

IPC分类号： A61M39/00 ,  A61M5/14

CPC分类号： A61M5/1407

摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a material which is permeable to the drug but which prevents convective loss of the IV fluid. A transdermal-type drug delivery device is adhered to the semipermeable/microporous wall portion. Drug is delivered by the delivery device through the wall portion and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the wall portion or a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the wall portion to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate.

摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。 室壁的一部分由药物可渗透的材料组成，但是防止IV流体的对流损失。 透皮型药物输送装置粘附在半透膜/微孔壁部分上。 药物由输送装置通过壁部分输送到流动的IV流体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 从装置向IV流体的药物递送速率由药物递送装置中的壁部分或膜层控制。 多个药物递送装置可以粘附到壁部分以递送多种药物或以更高的剂量率递送单一药物。

公开(公告)号：US4969871A

公开(公告)日：1990-11-13

申请号：US311906

申请日：1989-02-15

申请人： Felix Theeuwes ,  Su I. Yum

发明人： Felix Theeuwes ,  Su I. Yum

IPC分类号： A61M5/14

CPC分类号： A61M5/1407

摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a window material which allows the drug to diffuse therethrough but which prevents convective loss of the IV fluid. A flow distributor is provided within the chamber for distributing the flow of IV fluid along the interior surface of the window. A transdermal-type drug delivery device is adhered to the exterior surface of the window. Drug is delivered by the delivery device through the window and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the window itself or by a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the window to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate. A similar window may be placed in an IV bag to deliver a drug into the IV fluid therein.

摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。 室壁的一部分由允许药物扩散通过但防止IV流体的对流损失的窗口材料构成。 在室内提供流动分配器，用于沿着窗口的内表面分配IV流体流。 透皮型药物输送装置粘附在窗户的外表面上。 药物由输送装置通过窗口输送到流动的IV流体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 从装置向IV流体的药物递送速率由窗口本身或药物递送装置中的膜层控制。 多个药物递送装置可以粘附到窗户以递送多种药物或以更高的剂量率递送单一药物。 类似的窗口可以放置在IV袋中以将药物递送到其中的IV流体中。

公开(公告)号：US4938748A

公开(公告)日：1990-07-03

申请号：US239563

申请日：1988-09-01

申请人： Su I. Yum ,  Felix Theeuwes

发明人： Su I. Yum ,  Felix Theeuwes

IPC分类号： A61M25/00 ,  A61F5/441 ,  A61L29/00 ,  A61M1/00

CPC分类号： A61F5/441

摘要： A patient-care apparatus comprising a container for receiving a biological fluid, and a delivery device on the outside of the container, which device comprises a biocide that is released to the container for preventing the multiplication of and/or eliminating the presence of unwanted pathogens in the container.

公开(公告)号：US5045059A

公开(公告)日：1991-09-03

申请号：US568457

申请日：1990-08-15

申请人： Felix Theeuwes ,  Su I. Yum

发明人： Felix Theeuwes ,  Su I. Yum

IPC分类号： A61M5/14

CPC分类号： A61M5/1407

摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a window material which allows the drug to diffuse therethrough but which prevents convective loss of the IV fluid. A flow distributor is provided within the chamber for distributing the flow of IV fluid along the interior surface of the window. A transdermal-type drug delivery device is adhered to the exterior surface of the window. Drug is delivered by the delivery device through the window and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the window itself or by a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the window to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate. A similar window may be placed in an IV bag to deliver a drug into the IV fluid therein.

摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。 室壁的一部分由允许药物扩散通过但防止IV流体的对流损失的窗口材料构成。 在室内提供流动分配器，用于沿着窗口的内表面分配IV流体流。 透皮型药物输送装置粘附在窗户的外表面上。 药物由输送装置通过窗口输送到流动的IV流体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 从装置向IV流体的药物递送速率由窗口本身或药物递送装置中的膜层控制。 多个药物递送装置可以粘附到窗户以递送多种药物或以更高的剂量率递送单一药物。 类似的窗口可以放置在IV袋中以将药物递送到其中的IV流体中。

公开(公告)号：US5151093A

公开(公告)日：1992-09-29

申请号：US605593

申请日：1990-10-29

申请人： Felix Theeuwes ,  Su I. Yum

发明人： Felix Theeuwes ,  Su I. Yum

IPC分类号： A61K9/22 ,  A61M5/145 ,  A61M5/155

CPC分类号： A61M5/155 ,  A61M5/1452 ,  A61M2005/14513

摘要： An osmotically driven syringe (20, 60) is disclosed which can be used to deliver a beneficial agent such as a drug, at varying pre-determined rates over multiple periods of time. The syringe (20, 60) is driven by an osmotic engine (10) having a shaped wall (12) containing an osmotic agent (17) and/or a gas generating means (19), such as an effervescent couple. The wall (12) is composed of a semipermeable and/or microporous material which is permeable to an external liquid (e.g., water) but which is substantially impermeable to the osmotic agent (17) and the gas generated by the gas generating means (19). The wall (12) has a passageway (13) therethrough to provide a flow path for the driving fluid generated by the engine (10). The osmotic agent(s) (17) and/or the gas generating means (19) are placed in the engine (10) in such a way as to drive engine (10) at different pumping rates (R.sub.1, R.sub.2) over sequential periods of time (t.sub.o to t.sub.1 and t.sub.1 to t.sub.2).

摘要翻译： 公开了一种渗透驱动的注射器（20,60），其可以用于在多个时间段内以变化的预定速率递送有益剂例如药物。 注射器（20,60）由渗透引擎（10）驱动，渗透引擎（10）具有包含渗透剂（17）的成形壁（12）和/或诸如泡腾对之类的气体发生装置（19）。 壁（12）由半渗透和/或微孔材料组成，该材料可透过外部液体（例如水），但是渗透剂（17）和由气体发生装置（19）产生的气体基本上是不可渗透的 ）。 壁（12）具有穿过其中的通道（13），以为由发动机（10）产生的驱动流体提供流路。 渗透剂（17）和/或气体发生装置（19）以这样的方式被放置在发动机（10）中，以便在不同的泵送速率（R1，R2）上连续驱动发动机（10） 的时间（到t1到t1到t2）。

公开(公告)号：US4946456A

公开(公告)日：1990-08-07

申请号：US236868

申请日：1988-08-26

申请人： Nathan Roth ,  Su I. Yum ,  Felix Theeuwes

发明人： Nathan Roth ,  Su I. Yum ,  Felix Theeuwes

IPC分类号： A61K9/00 ,  A61K9/22

CPC分类号： A61K9/0004

摘要： An agent dispenser of the fluid imbibing type having a flexible bag within a membrane and in which a wicking or wetting device is in contact with the outer surface of the membrane to keep such outer surface wet at all times for all attitudes of a containment vessel housing the bag and the membrane. The wicking device is in the form of a fabric tube, such as a stretch knit fabric, or a preformed hydrophilic polymeric sleeve, which can be mounted on the outer surface of the membrane and remain in contact with it so long as there is any liquid in the containment vessel. Since the amount of water drawn by the wicking device is controlled by the membrane porosity and the amount of a solute composition in an intermediate layer between the bag and the membrane, the wicking device provides for a continuous controlled delivery of agent from the inner bag of the dispenser.

摘要翻译： 流体吸入型的药剂分配器在膜内具有柔性袋，并且其中芯吸或润湿装置与膜的外表面接触，以使所有这些外表面一直保持在容纳容器壳体的所有态度 袋子和膜。 芯吸装置是织物管的形式，例如拉伸针织织物或预先形成的亲水性聚合物套筒，其可以安装在膜的外表面上并保持与其接触，只要有任何液体 在遏制船上。 由于由芯吸装置吸收的水量由膜孔隙率和袋和膜之间的中间层中的溶质组成的量控制，所以芯吸装置提供从内袋的内袋中连续控制的药剂输送 分配器

公开(公告)号：US5160320A

公开(公告)日：1992-11-03

申请号：US741413

申请日：1991-08-12

申请人： Su I. Yum ,  Felix Theeuwes

发明人： Su I. Yum ,  Felix Theeuwes

IPC分类号： A61M5/14

CPC分类号： A61M5/1407

摘要： An agent formulator (30, 60) for an intravenous administration set (14) is provided. The intravenous administration set (14) includes a container (12) of an IV fluid (13), a drip chamber (22), an agent formulator (30, 60) and an adapter-needle assembly (28). The agent formulator (30, 60) has a fluid inlet (23) and a fluid outlet (25) for maintaining a flow of IV fluid (13 ) therethrough. A portion (36) of the formulator wall (32) is comprised of a window material which allows the agent to diffuse therethrough but which prevents convective loss of the IV fluid (13). A flow distributor (38, 68) is provided within the chamber for distributing the flow of IV fluid (13) along the interior surface of the window (36). A transdermal-type drug delivery device (40) is adhered to the exterior surface of the window (36). Drug is delivered by the delivery device (40) through the window (36) and into the flowing IV fluid (13). The device (40) delivers drug into the IV fluid (13) at a rate that is independent of the flow rate of IV fluid (13) through the formulator (30, 60). The rate of drug delivery from the device (40) into the IV fluid (13) is controlled by either the window (36) itself or by a membrance layer (46) in the drug delivery device (40). A plurality of drug delivery devices (40) may be adhered to the window (36) to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate. A similar window (11) may be placed in a IV bag to deliver a drug into the IV fluid therein.

摘要翻译： PCT No.PCT / US90 / 00880 Sec。 371日期1991年8月12日 102（e）日期1991年8月12日PCT提交1990年02月14日PCT公布。 出版物WO90 / 09201 日期为1990年8月23日。提供了一种用于静脉内给药组（14）的药剂配方（30,60）。 静脉内给药装置（14）包括IV流体（13），滴注室（22），药剂配制器（30,60）和适配器 - 针组件（28）的容器（12）。 药剂配制器（30,60）具有流体入口（23）和流体出口（25），用于维持IV流体（13）流过其中。 配方设计师壁（32）的一部分（36）由窗口材料构成，该窗材料允许试剂在其中扩散，但防止IV流体（13）的对流损失。 流体分配器（38,68）设置在腔室内，用于沿着窗口（36）的内表面分配IV流体（13）的流动。 透皮型药物输送装置（40）粘附到窗（36）的外表面。 药物通过输送装置（40）通过窗口（36）输送到流动的IV流体（13）中。 装置（40）以与通过配制器（30,60）的IV流体（13）的流速无关的速率将药物递送到IV流体（13）中。 从装置（40）进入IV流体（13）的药物递送速率由窗口（36）本身或药物递送装置（40）中的膜层（46）控制。 多个药物递送装置（40）可以粘附到窗口（36）以递送多种药物或以更高的剂量率递送单一药物。 类似的窗口（11）可以放置在IV袋中以将药物递送到其中的IV流体中。

公开(公告)号：US5104390A

公开(公告)日：1992-04-14

申请号：US503017

申请日：1990-04-02

申请人： Su I. Yum ,  Felix Theeuwes

发明人： Su I. Yum ,  Felix Theeuwes

IPC分类号： A61F5/441

CPC分类号： A61F5/441

摘要： A patient-care apparatus comprising a container for receiving a biological fluid, and a delivery device on the outside of the container, which device comprises a biocide that is released to the container for preventing the multiplication of and/or eliminating the presence of unwanted pathogens in the container.

摘要翻译： 包括用于接收生物流体的容器和在容器外部的输送装置的患者保养装置，该装置包括释放到容器中的杀生物剂，用于防止不希望的病原体的增殖和/或消除不需要的病原体的存在 在容器中

公开(公告)号：US4533348A

公开(公告)日：1985-08-06

申请号：US649778

申请日：1984-09-12

申请人： Allan M. Wolfe ,  James M. Davenport ,  Felix Theeuwes ,  Su I. Yum

发明人： Allan M. Wolfe ,  James M. Davenport ,  Felix Theeuwes ,  Su I. Yum

IPC分类号： A61M5/14

CPC分类号： A61M5/1409 ,  Y10T137/4891

摘要： A formulation dispenser is disclosed for use in a parenteral delivery system. The dispenser comprises an inlet for admitting fluid into the dispenser and an outlet for letting fluid leave the dispenser. A beneficial agent is housed in a formulation chamber in the dispenser and a membrane permeable to fluid and agent defines one boundary of the formulation chamber. A piston is slideably disposed in the dispenser for governing the flow of fluid through the dispenser, or for permitting fluid to contact the membrane and enter the formulation chamber for forming a solution containing agent that flows through the outlet into the parenteral system.

摘要翻译： 公开了一种用于肠胃外输送系统的制剂分配器。 分配器包括用于将流体引入分配器的入口和用于使流体离开分配器的出口。 有益剂容纳在分配器中的配制室中，并且可渗透流体和试剂的膜限定配方室的一个边界。 活塞可滑动地设置在分配器中，用于控制通过分配器的流体流动，或者允许流体接触膜并进入配制室，用于形成流过出口的肠溶液系统中的含有溶液的溶液。