公开(公告)号：US08497368B2

公开(公告)日：2013-07-30

申请号：US13389912

申请日：2010-08-10

申请人： Feng He ,  Miao Dai ,  Xingnian Fu ,  Yue Li ,  Lei Liu ,  Yuan Mi ,  Yao-chang Xu ,  Guoliang Xun ,  Zhengtian Yu ,  Ji Yue Zhang

发明人： Feng He ,  Miao Dai ,  Xingnian Fu ,  Yue Li ,  Lei Liu ,  Yuan Mi ,  Yao-chang Xu ,  Guoliang Xun ,  Zhengtian Yu ,  Ji Yue Zhang

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61P35/00 ,  A61P19/02

CPC分类号： C07D487/04

摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

摘要翻译： 本发明涉及式（I）的化合物及其盐：其中取代基如说明书中所定义; 用于治疗人或动物体的式（I）化合物，特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物，任选在组合配偶体存在下的药物组合物，以及制备式（I）化合物的方法。

公开(公告)号：US20120142681A1

公开(公告)日：2012-06-07

申请号：US13389912

申请日：2010-08-10

申请人： Feng He ,  Miao Dai ,  Xingnian Fu ,  Yue Li ,  Lei Liu ,  Yuan Mi ,  Yao-chang Xu ,  Guoliang Xun ,  Zhengtian Yu ,  Ji Yue Zhang

发明人： Feng He ,  Miao Dai ,  Xingnian Fu ,  Yue Li ,  Lei Liu ,  Yuan Mi ,  Yao-chang Xu ,  Guoliang Xun ,  Zhengtian Yu ,  Ji Yue Zhang

IPC分类号： A61K31/5377 ,  A61K31/5025 ,  A61P29/00 ,  A61K31/4985 ,  A61K31/53 ,  A61P35/00 ,  C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04

摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

摘要翻译： 本发明涉及式（I）的化合物及其盐：其中取代基如说明书中所定义; 用于治疗人或动物体的式（I）化合物，特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物，任选在组合配偶体存在下的药物组合物，以及制备式（I）化合物的方法。

公开(公告)号：US08507676B2

公开(公告)日：2013-08-13

申请号：US13567386

申请日：2012-08-06

申请人： Miao Dai ,  Xingnian Fu ,  Feng He ,  Lei Jiang ,  Yue Li ,  Fang Liang ,  Lei Liu ,  Yuan Mi ,  Yao-Chang Xu ,  Guoliang Xun ,  Xiaoxia Yan ,  Zhengtian Yu ,  Ji Yue Zhang

发明人： Miao Dai ,  Xingnian Fu ,  Feng He ,  Lei Jiang ,  Yue Li ,  Fang Liang ,  Lei Liu ,  Yuan Mi ,  Yao-Chang Xu ,  Guoliang Xun ,  Xiaoxia Yan ,  Zhengtian Yu ,  Ji Yue Zhang

IPC分类号： C07D487/04 ,  C07D403/12 ,  A61K31/4985 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

摘要翻译： 本发明涉及式（I）的化合物及其盐：其中取代基如说明书中所定义; 用于治疗人或动物体的式（I）化合物，特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物，任选在组合配偶体存在下的药物组合物，以及制备式（I）化合物的方法。

公开(公告)号：US08410264B2

公开(公告)日：2013-04-02

申请号：US12859653

申请日：2010-08-19

申请人： Miao Dai ,  Xingnian Fu ,  Feng He ,  Lei Jiang ,  Yue Li ,  Fang Liang ,  Lei Liu ,  Yuan Mi ,  Yao-chang Xu ,  Guoliang Xun ,  Xiaoxia Yan ,  Zhengtian Yu ,  Ji Yue Zhang

发明人： Miao Dai ,  Xingnian Fu ,  Feng He ,  Lei Jiang ,  Yue Li ,  Fang Liang ,  Lei Liu ,  Yuan Mi ,  Yao-chang Xu ,  Guoliang Xun ,  Xiaoxia Yan ,  Zhengtian Yu ,  Ji Yue Zhang

IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

公开(公告)号：US09580437B2

公开(公告)日：2017-02-28

申请号：US14977273

申请日：2015-12-21

申请人： Ho Man Chan ,  Xiang-Ju Justin Gu ,  Ying Huang ,  Ling Li ,  Yuan Mi ,  Wei Qi ,  Martin Sendzik ,  Yongfeng Sun ,  Long Wang ,  Zhengtian Yu ,  Hailong Zhang ,  Ji Yue (Jeff) Zhang ,  Man Zhang ,  Qiong Zhang ,  Kehao Zhao

发明人： Ho Man Chan ,  Xiang-Ju Justin Gu ,  Ying Huang ,  Ling Li ,  Yuan Mi ,  Wei Qi ,  Martin Sendzik ,  Yongfeng Sun ,  Long Wang ,  Zhengtian Yu ,  Hailong Zhang ,  Ji Yue (Jeff) Zhang ,  Man Zhang ,  Qiong Zhang ,  Kehao Zhao

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06 ,  A61K31/5377

CPC分类号： A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06 ,  C07D487/04

摘要： A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

摘要翻译： 提供式（I）化合物或其药学上可接受的盐，其已被证明可用于治疗PRC2介导的疾病或病症：其中R1，R2，R3，R4，R5和n如所定义 这里。

公开(公告)号：US20060074102A1

公开(公告)日：2006-04-06

申请号：US11129624

申请日：2005-05-13

申请人： Kevin Cusack ,  Jose-Andres Salmeron-Garcia ,  Thomas Gordon ,  Claude Barberis ,  Hamish Allen ,  Agniezka Bischoff ,  Anna Ericsson ,  Michael Friedman ,  Dawn George ,  Gregory Roth ,  Robert Talanian ,  Christine Thomas ,  Grier Wallace ,  Neil Wishart ,  Zhengtian Yu

发明人： Kevin Cusack ,  Jose-Andres Salmeron-Garcia ,  Thomas Gordon ,  Claude Barberis ,  Hamish Allen ,  Agniezka Bischoff ,  Anna Ericsson ,  Michael Friedman ,  Dawn George ,  Gregory Roth ,  Robert Talanian ,  Christine Thomas ,  Grier Wallace ,  Neil Wishart ,  Zhengtian Yu

IPC分类号： A61K31/4743 ,  C07D498/02

CPC分类号： C07D471/04 ,  A61K31/4743 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  Y02A50/481

摘要： A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

摘要翻译： 式（I）的化合物或其药学上可接受的盐，其中取代基如本文所定义，其可用作激酶抑制剂。