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11 条记录 (耗时 0.054 秒)

    Integrated catalytic converter and flexible endcone assembly
    3.
    发明申请
    Integrated catalytic converter and flexible endcone assembly 审中-公开
    集成式催化转化器和柔性端塞组件

    公开(公告)号：US20050036927A1

    公开(公告)日：2005-02-17

    申请号：US10952296

    申请日：2004-09-28

    申请人： Gregory Roth

    发明人： Gregory Roth

    IPC分类号： F01N3/28 ,  F01N13/18 ,  B01D53/92 ,  B01D53/94

    CPC分类号： F01N13/1816 ,  F01N3/2853 ,  F01N3/2857 ,  Y10T29/49345

    摘要： An catalytic converter is integrated with a flexible endcone to form an assembly. The assembly comprises a catalytic converter with a flexible endcone integrated connected to one end of the catalytic converter, which is optionally attached to a mounting flange or exhaust pipe. The endcone comprises a flexible bellow containing a plurality of undulating ribs. The flexible bellow is secured to an end of the catalytic converter at one or more interface points along the periphery of the flexible endcone assembly.

    摘要翻译： 催化转化器与柔性端塞一体化以形成组件。 组件包括具有与催化转化器的一端集成连接的柔性内胆的催化转化器，其可选地附接到安装法兰或排气管。 内胆包括含有多个起伏肋的柔性波纹管。 柔性波纹管在沿着柔性端框组件的周边的一个或多个界面点处固定到催化转化器的端部。

    6,7-epoxy paclitaxels
    4.
    发明授权
    6,7-epoxy paclitaxels 失效
    6,7环氧紫杉醇

    公开(公告)号：US5395850A

    公开(公告)日：1995-03-07

    申请号：US212468

    申请日：1994-03-10

    申请人： Gregory Roth

    发明人： Gregory Roth

    IPC分类号： A61K31/335 ,  A61P35/00 ,  C07D493/08 ,  A61K31/34 ,  A61K31/38 ,  C07D305/00

    CPC分类号： C07D493/08

    摘要： The present invention provides paclitaxel derivatives of formula I ##STR1## in which R.sup.1 is --COR.sup.z, in which R.sup.z is RR.sup.o N--, RHN--, RO-- or R;R.sup.2 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, or a radical of the formula --W--R.sup.x in which W is a bond, C.sub.2-6 alkenediyl, or --(CH.sub.2).sub.t --, in which t is one to six; and R.sup.x is naphthyl, phenyl, or heteroaryl, and furthermore R.sup.x can be optionally substituted with one to three same or different C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen or --CF.sub.3 groups;R and R.sup.o are independently C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl, C.sub.2-6 alkynyl, or phenyl, optionally substituted with one to three same or different C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen or --CF.sub.3 groups.Also provided by this invention are pharmaceutical formulations (compositions) and a method of treating mammalian tumors with a compound of formula I.

    摘要翻译： 本发明提供式I的紫杉醇衍生物，其中R1是-CORz，其中Rz是RRoN-，RHN-，RO-或R; R 2是C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-6环烷基或式-W-Rx的基团，其中W是键，C 2-6亚烯基或 - （CH 2）t - 其中t为1至6; 并且Rx是萘基，苯基或杂芳基，此外Rx可任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或-CF 3基团取代; R和R 4独立地为C 1-6烷基，C 2-6烯基，C 3-6环烷基，C 2-6炔基或苯基，任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或 - CF3组。 本发明还提供了药物制剂（组合物）和用式I化合物治疗哺乳动物肿瘤的方法。

    Ketone substituted benzimidazole compounds
    5.
    发明申请
    Ketone substituted benzimidazole compounds 审中-公开
    酮取代的苯并咪唑化合物

    公开(公告)号：US20050176792A1

    公开(公告)日：2005-08-11

    申请号：US11035876

    申请日：2005-01-07

    申请人： Kevin Moriarty ,  Lei Qiao ,  Gregory Roth

    发明人： Kevin Moriarty ,  Lei Qiao ,  Gregory Roth

    IPC分类号： A61K31/4184 ,  A61K31/42 ,  C07D235/30 ,  C07D413/02 ,  C07D45/02

    CPC分类号： C07D235/30

    摘要： Disclosed are ketone substituted benzimidazole compounds of formula(I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.

    摘要翻译： 公开了式（I）的酮取代的苯并咪唑化合物：其中R 1，R 2，R 3，R 4， SUB＆gt;和X＆lt; a＆gt;在本文中定义。 本发明的化合物抑制Itk激酶，因此可用于治疗涉及炎症，免疫学障碍和过敏性疾病的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。