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公开(公告)号：US07429462B2
公开(公告)日：2008-09-30
申请号：US11706809
申请日：2007-02-15
IPC分类号： C12Q1/54
CPC分类号： G01N33/6893 , G01N33/66 , G01N2800/042
摘要： The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.
摘要翻译： 本发明提供体内筛选测定和用于快速筛选糖尿病的体外筛选测定。 本发明的方法包括确定患者眼部流体中的第一葡萄糖浓度; 向患者口服负荷的碳水化合物; 在口服施用碳水化合物之后，在小于50分钟的时间段确定患者眼液中的第二葡萄糖浓度; 将第二葡萄糖浓度与第一葡萄糖浓度进行比较以确定患者是否可能是糖尿病。 本发明的方法通过使用本发明的试剂盒进行。 该试剂盒包括：（1）葡萄糖感测眼科装置和使用葡萄糖感测眼科装置筛查糖尿病的说明书; 或（2）两种或更多种泪液收集装置，以及与葡萄糖特异性反应以形成可检测信号的检测剂组合物。 葡萄糖感测眼科装置包括与葡萄糖特异性和可逆地相互作用以形成以浓度依赖性方式变化的可检测光学信号的测试剂组合物。
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公开(公告)号：US07244394B2
公开(公告)日：2007-07-17
申请号：US10654196
申请日：2003-09-03
IPC分类号： G01N21/00 , G01N31/22 , C08F16/06 , C08F116/06 , C08F216/06 , A61M35/00
CPC分类号： A61B10/0045 , A61B2010/0067
摘要： The invention, in one aspect, provides a strip for tear collection. The strip has a first end and an opposite second end and preferably has substantially uniform cross-sections from the first end to the second end. The strip is made of a hydrogel material in substantially dry state. The strip is characterized by having a substantially uniform swelling along the hydrogel strip from the first end to the second end when fully wicked by a tear fluid and by having a correlation between the volume of tear uptake by said strip and the length of the wicked end portion of said strip. A strip of the invention is useful for assay of an analyte of interest in a tear fluid. The invention also provides a method and kits for assaying an analyte of interest (e.g., lactoferrin, glucose, herpes simplex virus, hormones, etc.).
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公开(公告)号：US08268763B2
公开(公告)日：2012-09-18
申请号：US12310189
申请日：2007-08-14
IPC分类号： C11D3/386
CPC分类号： C11D3/0078 , A61L12/082 , A61L12/124 , A61L12/142 , A61L12/143 , C11D3/38 , C11D3/38618 , C11D3/40 , C11D3/48
摘要： The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention comprises a colored lens care solution including a colored protein and a proteolytic enzyme. The kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention relies upon a color change to indicate the completion of disinfection and cleaning of contact lenses.
摘要翻译： 本发明提供一种用于消毒和清洁隐形眼镜的镜片护理套件。 本发明的镜片护理套件包括着色透镜护理溶液，其包括着色蛋白质和蛋白水解酶。 本发明的试剂盒允许客户在视觉上识别何时他们的镜片消毒，清洁并准备穿戴。 本发明依赖于颜色变化来指示隐形眼镜的消毒和清洁的完成。
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4.发明授权公开(公告)号：US08091568B2
公开(公告)日：2012-01-10
申请号：US12310190
申请日：2007-08-14
申请人： Jennifer Dawn Lane , Dawn A. Smith
发明人： Jennifer Dawn Lane , Dawn A. Smith
IPC分类号： B08B3/04
CPC分类号： A61L12/124 , A61L12/086 , A61L12/142 , C11D3/0078 , Y10S134/901
摘要： The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention is relied on color change, due to temporally photo-bleaching of a colored lens care solution, to indicate the readiness of disinfection and cleaning of contact lenses.
摘要翻译： 本发明提供一种用于消毒和清洁隐形眼镜的镜片护理套件。 本发明的镜片护理套件允许客户在视觉上识别镜片何时消毒，清洁并准备穿戴。 由于彩色透镜护理溶液的暂时照相漂白，本发明依赖于颜色变化，以指示隐形眼镜的消毒和清洁的准备。
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公开(公告)号：US08062607B2
公开(公告)日：2011-11-22
申请号：US12309347
申请日：2007-07-13
IPC分类号： A61L9/00 , B01J19/00 , G01D11/26 , A45C11/04 , B65D73/00 , B65D83/04 , B65D35/00 , A61K7/075 , A61K9/00 , G01N31/00 , A01K43/00
CPC分类号： C11D3/0078 , A61L12/086 , A61L12/124 , A61L12/142 , C11D1/345 , C11D3/1246 , C11D3/128 , C11D3/14 , C11D3/3726 , C11D3/3947 , C11D3/40 , C11D11/0058 , Y10S134/901 , Y10S514/839 , Y10S514/84
摘要： The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention is relied on color change to indicate the readiness of disinfection and cleaning of contact lenses.
摘要翻译： 本发明提供一种用于消毒和清洁隐形眼镜的镜片护理套件。 本发明的镜片护理套件允许客户在视觉上识别镜片何时消毒，清洁并准备穿戴。 本发明依赖于颜色变化来指示隐形眼镜的消毒和清洁的准备。
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公开(公告)号：US20090324466A1
公开(公告)日：2009-12-31
申请号：US12309347
申请日：2007-07-13
IPC分类号： A61L12/08
CPC分类号： C11D3/0078 , A61L12/086 , A61L12/124 , A61L12/142 , C11D1/345 , C11D3/1246 , C11D3/128 , C11D3/14 , C11D3/3726 , C11D3/3947 , C11D3/40 , C11D11/0058 , Y10S134/901 , Y10S514/839 , Y10S514/84
摘要： The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention is relied on color change to indicate the readiness of disinfection and cleaning of contact lenses.
摘要翻译： 本发明提供一种用于消毒和清洁隐形眼镜的镜片护理套件。 本发明的镜片护理套件允许客户在视觉上识别镜片何时消毒，清洁并准备穿戴。 本发明依赖于颜色变化来指示隐形眼镜的消毒和清洁的准备。
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公开(公告)号：US20090247443A1
公开(公告)日：2009-10-01
申请号：US12310189
申请日：2007-08-14
IPC分类号： C11D3/40
CPC分类号： C11D3/0078 , A61L12/082 , A61L12/124 , A61L12/142 , A61L12/143 , C11D3/38 , C11D3/38618 , C11D3/40 , C11D3/48
摘要： The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention comprises a colored lens care solution including a colored protein and a proteolytic enzyme. The kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention relies upon a color change to indicate the completion of disinfection and cleaning of contact lenses.
摘要翻译： 本发明提供一种用于消毒和清洁隐形眼镜的镜片护理套件。 本发明的镜片护理套件包括着色透镜护理溶液，其包括着色蛋白质和蛋白水解酶。 本发明的试剂盒允许客户在视觉上识别何时他们的镜片消毒，清洁并准备穿戴。 本发明依赖于颜色变化来指示隐形眼镜的消毒和清洁的完成。
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8.发明申请公开(公告)号：US20090199878A1
公开(公告)日：2009-08-13
申请号：US12310190
申请日：2007-08-14
申请人： Jennifer Dawn Lane , Dawn A. Smith
发明人： Jennifer Dawn Lane , Dawn A. Smith
CPC分类号： A61L12/124 , A61L12/086 , A61L12/142 , C11D3/0078 , Y10S134/901
摘要： The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention is relied on color change, due to temporally photo-bleaching of a colored lens care solution, to indicate the readiness of disinfection and cleaning of contact lenses.
摘要翻译： 本发明提供一种用于消毒和清洁隐形眼镜的镜片护理套件。 本发明的镜片护理套件允许客户在视觉上识别镜片何时消毒，清洁并准备穿戴。 由于彩色透镜护理溶液的暂时照相漂白，本发明依赖于颜色变化，以指示隐形眼镜的消毒和清洁的准备。
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