公开(公告)号：US20240180941A1

公开(公告)日：2024-06-06

申请号：US18495450

申请日：2023-10-26

申请人： Flagship Pioneering Innovations V, Inc.

发明人： Steven John TAYLOR ,  John Robert PROUDFOOT ,  Mi-Jeong KIM ,  Kathleen NUDEL ,  Timothy F. BRIGGS ,  Afrand KAMALI SARVESTANI ,  Leonard BUCKBINDER ,  Bernard LANTER ,  Ferdinand Edward MASSARI ,  Koji YASUDA ,  Spencer Cory PECK ,  Cheri SNEDEKER ,  Diana LE ,  Jessica ALEXANDER ,  Anna LIANG ,  Dinara GUNASEKERA ,  David Arthur BERRY ,  John Patrick CASEY, JR.

IPC分类号： A61K31/7028 ,  A61K45/06 ,  A61P3/10

CPC分类号： A61K31/7028 ,  A61K45/06 ,  A61P3/10

摘要： Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.

公开(公告)号：US20220110960A1

公开(公告)日：2022-04-14

申请号：US17557772

申请日：2021-12-21

申请人： Flagship Pioneering Innovations V, Inc.

发明人： Steven John TAYLOR ,  Mi-Jeong KIM ,  Kathleen NUDEL ,  Timothy F. BRIGGS ,  Koji YASUDA ,  Leonard BUCKBINDER ,  Bernard LANTER ,  Spencer Cory PECK ,  Cheri SNEDEKER ,  Angela SHE ,  Jessica ALEXANDER ,  Anna LIANG ,  Jenny LIU ,  Dinara GUNASEKERA ,  David Arthur BERRY ,  John Patrick CASEY, JR. ,  Amir H. MOAREFI

IPC分类号： A61K31/7036 ,  A61P37/06 ,  A61K9/00 ,  A61K31/191 ,  A61K31/196 ,  A61K31/353 ,  A61K31/519

摘要： Disclosed herein are acylated active agents and methods of their use, e.g., for modulating an autoimmunity marker or for treating an autoimmune disorder.

公开(公告)号：US20210177877A1

公开(公告)日：2021-06-17

申请号：US16950120

申请日：2020-11-17

申请人： Flagship Pioneering Innovations V, Inc.

发明人： Steven John TAYLOR ,  John Robert PROUDFOOT ,  Mi-Jeong KIM ,  Kathleen NUDEL ,  Timothy F. BRIGGS ,  Afrand KAMALI SARVESTANI ,  Leonard BUCKBINDER ,  Bernard LANTER ,  Ferdinand Edward MASSARI ,  Koji YASUDA ,  Spencer Cory PECK ,  Cheri SNEDEKER ,  Diana LE ,  Jessica ALEXANDER ,  Anna LIANG ,  Dinara GUNASEKERA ,  David Arthur BERRY ,  John Patrick CASEY, JR.

IPC分类号： A61K31/7028 ,  A61P3/10 ,  A61K45/06

摘要： Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.

公开(公告)号：US20210299079A1

公开(公告)日：2021-09-30

申请号：US17337595

申请日：2021-06-03

申请人： Flagship Pioneering Innovations V, Inc.

发明人： John Patrick CASEY, JR. ,  David Arthur BERRY ,  Jessica Elizabeth ALEXANDER ,  Timothy BRIGGS ,  Leonard BUCKBINDER ,  Dinara Shashanka GUNASEKERA ,  Afrand KAMALI SARVESTANI ,  Mi-Jeong KIM ,  Bernard LANTER ,  Anna LIANG ,  Kathleen NUDEL ,  Spencer Cory PECK ,  Cheri ROSS ,  Steven John TAYLOR ,  Koji YASUDA

IPC分类号： A61K31/225 ,  A61K47/54 ,  A61P25/28 ,  A61P37/06

摘要： Disclosed are conjugates of monomethyl fumarate and a carrier group or aminocarrier group, or a pharmaceutically acceptable salt thereof. In the conjugates, monomethyl fumarate acyl is covalently bonded to the carrier group or aminocarrier group through a carbon-oxygen bond that is cleavable in vivo. The carrier group may include a core, e.g., a monosaccharide, a sugar acid (e.g., acid monosaccharide), a sugar alcohol, or a catechin polyphenol. The aminocarrier group may include a core, e.g., an aminomonosaccharide. The carrier group or aminocarrier group may include, e.g., at least one short chain fatty acid acyl, at least one tryptophan analogue, at least one ketone body, or at least one pre-ketone body. Also disclosed are pharmaceutical compositions containing the conjugates and methods of their use.

公开(公告)号：US20210283157A1

公开(公告)日：2021-09-16

申请号：US17319285

申请日：2021-05-13

申请人： Flagship Pioneering Innovations V, Inc.

发明人： Steven John TAYLOR ,  Mi-Jeong KIM ,  Kathleen NUDEL ,  Timothy F. BRIGGS ,  Koji YASUDA ,  Leonard BUCKBINDER ,  Bernard LANTER ,  Spencer Cory PECK ,  Cheri SNEDEKER ,  Angela SHE ,  Jessica ALEXANDER ,  Anna LIANG ,  Jenny LIU ,  Dinara GUNASEKERA ,  David Arthur BERRY ,  John Patrick CASEY, JR. ,  Amir H. MOAREFI

IPC分类号： A61K31/7036 ,  A61P37/06 ,  A61K9/00 ,  A61K31/191 ,  A61K31/196 ,  A61K31/353 ,  A61K31/519

摘要： Disclosed herein are acylated active agents and methods of their use, e.g., for modulating an autoimmunity marker or for treating an autoimmune disorder.