公开(公告)号：US20240361301A1

公开(公告)日：2024-10-31

申请号：US18687654

申请日：2022-09-09

Applicant: Flagship Pioneering Innovations VI, LLC

Inventor： Morag Helen STEWART ,  Angeliki CHALKIADAKI ,  Yuge JI ,  Fabian Alexander WOLF ,  Nicholas McCartney PLUGIS ,  Poorya HOSSEINI ,  Inna LIPCHINA ,  Sophie Andrea TRITSCHLER

IPC: G01N33/50 ,  A61K45/06 ,  C12N5/071

CPC classification number: G01N33/5088 ,  A61K45/06 ,  C12N5/0679 ,  G01N33/5023 ,  C12N2503/04 ,  C12N2533/90

Abstract: The present disclosure relates, inter alia, to perturbagens and methods for directing a change in the cell state of an intestinal stem cell and/or a basal cell. It also relates to methods for increasing a quantity of goblet progenitors, goblet cells, Paneth cells, and/or enteroendocrine cells or immediate progenitors thereof and/or the ratios thereof, and methods for decreasing the function and quantity of goblet cells or immediate progenitors thereof. Further, the present disclosure relates to methods for treating diseases or disorders characterized by, at least, abnormal function, abnormal ratios and/or abnormal numbers of goblet progenitors, goblet cells, Paneth cells, and/or enteroendocrine cells, or immediate progenitors thereof.