公开(公告)号：US20240336945A1

公开(公告)日：2024-10-10

申请号：US18292098

申请日：2022-07-26

申请人： Flagship Pioneering Innovations VI, LLC

发明人： David Arthur Berry ,  Theonie Anastassiadis ,  Christine Elizabeth Hajdin ,  Noubar Boghos Afeyan

IPC分类号： C12P19/34 ,  A61K31/7105 ,  C12N15/10

CPC分类号： C12P19/34 ,  A61K31/7105 ,  C12N15/1003

摘要： The invention relates generally to tRNA-based effector molecules and methods relating thereto.

公开(公告)号：US12121531B2

公开(公告)日：2024-10-22

申请号：US17519120

申请日：2021-11-04

申请人： Flagship Pioneering Innovations VI, LLC

发明人： Theonie Anastassiadis ,  David Charles Donnell Butler ,  Neil Kubica ,  Qingyi Li

IPC分类号： A61K31/7088 ,  A61K31/712 ,  A61K31/7125 ,  C12N15/11 ,  C12N15/67

CPC分类号： A61K31/7088 ,  A61K31/712 ,  A61K31/7125 ,  C12N15/11 ,  C12N15/67 ,  C12N2310/313 ,  C12N2310/321 ,  C12N2310/322

摘要： The invention relates generally to tRNA-based effector molecules having a non-naturally occurring modification and methods relating thereto.

公开(公告)号：US20240175020A1

公开(公告)日：2024-05-30

申请号：US18269450

申请日：2021-12-23

申请人： Flagship Pioneering Innovations VI, LLC

发明人： Theonie Anastassiadis ,  David Charles Donnell Butler ,  Neil Kubica ,  Qingyi Li ,  Armand Gatien Ngounou Wetie ,  Guangliang Wang

IPC分类号： C12N15/113 ,  C12N15/67

CPC分类号： C12N15/113 ,  C12N15/67 ,  C12N2310/351 ,  C12N2320/34

摘要： The invention relates generally to tRNA-based effector molecules (TREMs) comprising an asialoglycoprotein receptor (ASGPR) binding moiety, as well as compositions and methods relating thereto.

公开(公告)号：US20230203509A1

公开(公告)日：2023-06-29

申请号：US17928450

申请日：2021-05-28

申请人： Flagship Pioneering Innovations VI, LLC

发明人： Theonie Anastassiadis ,  David Arthur Berry ,  Christine Elizabeth Hajdin ,  Noubar Boghos Afeyan ,  David Charles Donnell Butler ,  Qingyi Li

IPC分类号： C12N15/67 ,  C12N15/11

CPC分类号： C12N15/67 ,  C12N15/11 ,  C12N2310/10 ,  C12N2320/34

摘要： The disclosure relates generally to uses of tRNA-based effector molecules having a non-naturally occurring modification.

公开(公告)号：US20230203510A1

公开(公告)日：2023-06-29

申请号：US17928463

申请日：2021-05-28

申请人： Flagship Pioneering Innovations VI, LLC

发明人： Theonie Anastassiadis ,  David Charles Donnell Butler ,  Neil Kubica ,  Qingyi Li

IPC分类号： C12N15/67

CPC分类号： C12N15/67

摘要： The disclosure relates generally to methods of modulating a production parameter of an RNA corresponding to, or polypeptide encoded by, a nucleic acid sequence comprising an endogenous ORF having a premature termination codon, comprising administering a tRNA-based effector molecule having a non-naturally occurring modification.

公开(公告)号：US20230054178A1

公开(公告)日：2023-02-23

申请号：US17519120

申请日：2021-11-04

申请人： Flagship Pioneering Innovations VI, LLC

发明人： Theonie Anastassiadis ,  David Charles Donnell Butler ,  Neil Kubica ,  Qingyi Li

IPC分类号： A61K31/7088

摘要： The invention relates generally to tRNA-based effector molecules having a non-naturally occurring modification and methods relating thereto.