公开(公告)号：US20240374605A1

公开(公告)日：2024-11-14

申请号：US18292582

申请日：2022-07-29

Applicant: Foghorn Therapeutics Inc.

Inventor： Ammar Adam ,  Kana Ichikawa ,  Martin F. Hentemann ,  Lan Xu

IPC: A61K31/5377 ,  A61K31/4184 ,  A61K31/497 ,  A61K31/517 ,  A61K31/519 ,  A61K35/17 ,  A61K45/06 ,  A61P35/04

Abstract: The present disclosure features useful methods to treat cancer, e.g., in a subject in need thereof. In some embodiments, the methods described include administering an agent that reduces the level and/or activity of BRM/BRG1 in combination with an immunotherapy. In some embodiments, the immunotherapy is administered concurrently with the agent that reduces the level and/or activity of BRM and/or BRG1 in the subject. In some embodiments, the immunotherapy is administered prior to the agent that reduces the level and/or activity of BRM and/or BRG1 in the subject. In some embodiments, the immunotherapy is administered subsequent to the agent that reduces the level and/or activity of BRM and/or BRG1 in the subject.