公开(公告)号：US10004636B2

公开(公告)日：2018-06-26

申请号：US15230275

申请日：2016-08-05

Applicant: Forsight Vision5, Inc.

Inventor： Yair Alster ,  Eugene de Juan, Jr. ,  Cary J. Reich ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  K. Angela Macfarlane ,  Douglas Sutton

IPC: A61F9/00 ,  A61M35/00 ,  A61K9/00 ,  A61K31/19 ,  A61K31/407 ,  A61K31/4178 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/43 ,  A61K31/55 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/56 ,  A61K31/568 ,  A61K31/573 ,  A61K31/58 ,  A61K31/7036 ,  A61K38/00 ,  A61M31/00 ,  A61K31/335

CPC classification number: A61F9/0026 ,  A61F9/0017 ,  A61K9/0051 ,  A61K31/19 ,  A61K31/335 ,  A61K31/407 ,  A61K31/4178 ,  A61K31/43 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/55 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/56 ,  A61K31/568 ,  A61K31/573 ,  A61K31/58 ,  A61K31/7036 ,  A61K38/00 ,  A61M31/002

Abstract: A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.

公开(公告)号：US09937073B2

公开(公告)日：2018-04-10

申请号：US14600505

申请日：2015-01-20

Applicant: ForSight Vision5, Inc.

Inventor： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela Macfarlane ,  Janelle Chang ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  Douglas Sutton ,  Alexander J. Gould

IPC: A61F9/00 ,  A61K9/00 ,  A61B17/00 ,  A61L27/02 ,  A61L27/16 ,  A61K47/34

CPC classification number: A61F9/0017 ,  A61B17/00234 ,  A61K9/0051 ,  A61K47/34 ,  A61L27/025 ,  A61L27/16

Abstract: A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

公开(公告)号：US10736774B2

公开(公告)日：2020-08-11

申请号：US16003857

申请日：2018-06-08

Applicant: ForSight Vision5, Inc.

Inventor： Yair Alster ,  Eugene de Juan, Jr. ,  Cary J. Reich ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  K. Angela Macfarlane ,  Douglas Sutton

IPC: A61F9/00 ,  A61K31/55 ,  A61K31/5377 ,  A61K31/5575 ,  A61K31/407 ,  A61K31/58 ,  A61K38/00 ,  A61K31/5415 ,  A61K31/43 ,  A61K31/19 ,  A61K31/557 ,  A61K31/4178 ,  A61K31/7036 ,  A61K31/573 ,  A61K31/568 ,  A61K9/00 ,  A61M31/00 ,  A61K31/335 ,  A61K31/56

Abstract: A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.

公开(公告)号：US20200038240A1

公开(公告)日：2020-02-06

申请号：US16599828

申请日：2019-10-11

Applicant: ForSight Vision5, Inc.

Inventor： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela Macfarlane ,  Janelle Chang ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  Douglas Sutton ,  Alexander J. Gould

IPC: A61F9/00 ,  A61L27/16 ,  A61L27/02 ,  A61B17/00 ,  A61K9/00

Abstract: A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.