公开(公告)号：US08460361B2

公开(公告)日：2013-06-11

申请号：US11180165

申请日：2005-07-13

Applicant: Forrest D. Whitcher ,  Makoto Takeuchi

Inventor： Forrest D. Whitcher ,  Makoto Takeuchi

IPC: A61F2/06

CPC classification number: C23C14/34 ,  A61F2/82 ,  A61F2210/0014 ,  A61F2240/001 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00059 ,  A61F2310/00071 ,  A61F2310/00089 ,  A61F2310/00095 ,  A61F2310/00113 ,  A61F2310/00131 ,  A61F2310/00149 ,  A61F2310/00155 ,  A61L31/022 ,  C23C14/0005 ,  C23C14/562

Abstract: A method of forming a medical device, the method including the steps of providing a substrate, depositing a metallic layer on the substrate by a vapor deposition process, and removing the metallic layer from the substrate. The metallic layer thus removed is the medical device or serves as a basis for forming the medical device. In another aspect, the present invention includes a medical device formed by the process of the present invention.

公开(公告)号：US06589266B2

公开(公告)日：2003-07-08

申请号：US09908318

申请日：2001-07-18

Applicant: Forrest D. Whitcher ,  Alan Kaganov ,  Sally C. Thornton

Inventor： Forrest D. Whitcher ,  Alan Kaganov ,  Sally C. Thornton

IPC: A61M2900

CPC classification number: A61F2/01 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/0067

Abstract: A thrombosis filter configured for placement within a blood vessel lumen. The thrombosis filter of the present invention includes a body element, a plurality of struts, and a surface treatment. The surface treatment, comprised in part of an anti-proliferative or anti-angiogenic drug, is applied to portions of the thrombosis filter in order to regulate neointimal growth around the thrombosis filter and its anchor elements. The thrombosis filter may further contain a first and a second surface treatment layer. The first surface treatment layer possesses endothelial cell growth enhancing properties, while the second surface treatment layer includes the anti-proliferative or anti-angiogenic drug. The surface treatment may alternatively be applied to a substrate, which in turn is applied to the filter.

Abstract translation: 构造成用于放置在血管腔内的血栓形成过滤器。 本发明的血栓形成过滤器包括身体元件，多个支柱和表面处理。 部分抗增殖或抗血管生成药物的表面处理被应用于血栓形成过滤器的部分，以调节血栓形成过滤器及其锚定元件周围的新生内膜生长。 血栓形成过滤器还可以包含第一和第二表面处理层。 第一表面处理层具有内皮细胞生长增强特性，而第二表面处理层包括抗增殖或抗血管生成药物。 表面处理可以替代地施加到衬底，衬底又被施加到过滤器。

公开(公告)号：US06416530B2

公开(公告)日：2002-07-09

申请号：US09904259

申请日：2001-07-12

Applicant: Robert B. DeVries ,  Hannah Shu Kim ,  Naroun Soun ,  Forrest D. Whitcher ,  Mark W. Wolfson

Inventor： Robert B. DeVries ,  Hannah Shu Kim ,  Naroun Soun ,  Forrest D. Whitcher ,  Mark W. Wolfson

IPC: A61M2900

CPC classification number: A61F2/01 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2250/0071

Abstract: A thrombus filter which can be securely fixed in a selected location in the vascular system of a patient and removed when no longer required. The thrombus filter includes a plurality of struts which radiate from a body portion to form the generally conical shape of the thrombus filter. The thrombus filter includes anchor members joined to the free end of each strut. The thrombus filter includes an insulating layer substantially covering the thrombus filter including the body portion, the struts and the anchor members. The insulating layer includes an opening proximate the anchor members. The opening in the insulating layer creates a conductive path between the thrombus filter and the patient's body. When removal of the thrombus filter is desired, a first electrical conductor forms an electrical connection with the body portion of the thrombus filter. A second electrical conductor forms an electrical connection with the patient's body. A power supply is used to selectively apply a voltage differential between the thrombus filter and the body of the patient. This voltage differential induces an electrical current the flow of electrical current between the thrombus filter and the patient's blood causes the electrolytic corrosion of the thrombus filter proximate the opening in the insulating layer. When the bond between the struts of the thrombus filter and the anchors is cut through or weakened, the thrombus filter may be pulled into the lumen of a retrieval catheter. Removal of the thrombus filter from the patient's body is completed by withdrawing the retrieval catheter from the patient's blood vessel.

公开(公告)号：US06342063B1

公开(公告)日：2002-01-29

申请号：US09491273

申请日：2000-01-26

Applicant: Robert B. DeVries ,  Hannah Shu Kim ,  Naroun Soun ,  Forrest D. Whitcher ,  Mark W. Wolfson

Inventor： Robert B. DeVries ,  Hannah Shu Kim ,  Naroun Soun ,  Forrest D. Whitcher ,  Mark W. Wolfson

IPC: A61M2900

CPC classification number: A61F2/01 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2250/0071

Abstract: A thrombus filter which can be securely fixed in a selected location in the vascular system of a patient and removed when no longer required. The thrombus filter includes a plurality of struts which radiate from a body portion to form the generally conical shape of the thrombus filter. The thrombus filter includes anchor members joined to the free end of each strut. The thrombus filter includes an insulating layer substantially covering the thrombus filter including the body portion, the struts and the anchor members. The insulating layer includes an opening proximate the anchor members. The opening in the insulating layer creates a conductive path between the thrombus filter and the patient's body. When removal of the thrombus filter is desired, a first electrical conductor forms an electrical connection with the body portion of the thrombus filter. A second electrical conductor forms an electrical connection with the patient's body. A power supply is used to selectively apply a voltage differential between the thrombus filter and the body of the patient. This voltage differential induces an electrical current the flow of electrical current between the thrombus filter and the patient's blood causes the electrolytic corrosion of the thrombus filter proximate the opening in the insulating layer. When the bond between the struts of the thrombus filter and the anchors is cut through or weakened, the thrombus filter may be pulled into the lumen of a retrieval catheter. Removal of the thrombus filter from the patient's body is completed by withdrawing the retrieval catheter from the patient's blood vessel.

Abstract translation: 一种血栓过滤器，其可以牢固地固定在患者的血管系统中的选定位置，并且在不再需要时被去除。 血栓过滤器包括从主体部分辐射以形成血栓过滤器的大致圆锥形状的多个支柱。 血栓过滤器包括连接到每个支柱的自由端的锚定构件。 血栓过滤器包括基本上覆盖包括主体部分，支柱和锚定构件的血栓过滤器的绝缘层。 绝缘层包括靠近锚构件的开口。 绝缘层中的开口在血栓过滤器和患者身体之间形成导电路径。 当需要去除血栓过滤器时，第一电导体与血栓过滤器的主体部分形成电连接。 第二电导体与患者的身体形成电连接。 使用电源来选择性地在血栓过滤器和患者身体之间施加电压差。 该电压差引起电流，血栓过滤器和患者血液之间的电流流动导致邻近绝缘层开口处的血栓过滤器的电解腐蚀。 当血栓过滤器的支柱和锚固件之间的连接被切断或削弱时，血栓过滤器可以被拉入回收导管的内腔。 通过从患者血管中取出取出导管来完成从患者体内去除血栓滤过器。

公开(公告)号：US06273901B1

公开(公告)日：2001-08-14

申请号：US09371305

申请日：1999-08-10

Applicant: Forrest D. Whitcher ,  Alan Kaganov ,  Sally C. Thornton

Inventor： Forrest D. Whitcher ,  Alan Kaganov ,  Sally C. Thornton

IPC: A61M2900

CPC classification number: A61F2/01 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/0067

Abstract: A thrombosis filter configured for placement within a blood vessel lumen. The thrombosis filter of the present invention includes a body element, a plurality of struts, and a surface treatment. The surface treatment, comprised in part of an anti-proliferative or anti-angiogenic drug, is applied to portions of the thrombosis filter in order to regulate neointimal growth around the thrombosis filter and its anchor elements. The thrombosis filter may further contain a first and a second surface treatment layer. The first surface treatment layer possesses endothelial cell growth enhancing properties, while the second surface treatment layer includes the anti-proliferative or anti-angiogenic drug. The surface treatment may alternatively be applied to a substrate, which in turn is applied to the filter.