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公开(公告)号：US20180134696A1
公开(公告)日：2018-05-17
申请号：US15736235
申请日：2016-06-09
发明人： Raksha Acharya , Duane A. Burnett , Matthew Gregory Bursavich , Andrew Simon Cook , Bryce Alden Harrison , Andrew J. McRiner
IPC分类号： C07D453/02 , A61P25/00
CPC分类号： C07D453/02 , A61P25/00
摘要： The present invention relates to novel aminobenzisoxazole compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of Alpha7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
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公开(公告)号：US20170247393A1
公开(公告)日：2017-08-31
申请号：US15291740
申请日：2016-10-12
发明人： Raksha Acharya , Duane A. Burnett , Matthew Gregory Bursavich , Andrew Simon Cook , Bryce Alden Harrison , Andrew J. McRiner
IPC分类号： C07D498/20 , C07D519/00
CPC分类号： C07D498/20 , C07D519/00
摘要： The present invention relates to novel aminoisoxazoline compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
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3.发明授权公开(公告)号：US10428062B2
公开(公告)日：2019-10-01
申请号：US15233664
申请日：2016-08-10
发明人： Raksha Acharya , Duane A. Burnett , Matthew Gregory Bursavich , Andrew Simon Cook , Bryce Alden Harrison , Andrew J. McRiner
IPC分类号： C07D453/02 , C07D453/00 , A61P25/00
摘要： The present invention relates to novel geminal substituted aminobenzisoxazole compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
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公开(公告)号：US20170066753A1
公开(公告)日：2017-03-09
申请号：US15178626
申请日：2016-06-10
发明人： Raksha Acharya , Duane A. Burnett , Matthew Gregory Bursavich , Andrew Simon Cook , Bryce Alden Harrison , Andrew J. McRiner
IPC分类号： C07D413/14 , C07D417/14 , C07D471/04 , C07D413/04
CPC分类号： C07D413/14 , A61K31/535 , C07D247/02 , C07D271/02 , C07D273/02 , C07D273/04 , C07D413/04 , C07D417/14 , C07D471/04
摘要： The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for using an oxadiazine compound in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of an oxadiazine compound.
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公开(公告)号：US10370370B2
公开(公告)日：2019-08-06
申请号：US15736235
申请日：2016-06-09
发明人： Raksha Acharya , Duane A. Burnett , Matthew Gregory Bursavich , Andrew Simon Cook , Bryce Alden Harrison , Andrew J. McRiner
IPC分类号： C07D453/02 , A61P25/00
摘要： The present invention relates to novel aminobenzisoxazole compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of Alpha7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
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6.发明申请Geminal Substituted Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors 审中-公开Geminal取代的氨基苯并恶唑化合物作为α7-烟酰乙酰胆碱受体的激动剂公开(公告)号：US20170044155A1
公开(公告)日：2017-02-16
申请号：US15233664
申请日：2016-08-10
发明人： Raksha Acharya , Duane A. Burnett , Matthew Gregory Bursavich , Andrew Simon Cook , Bryce Alden Harrison , Andrew J. McRiner
IPC分类号： C07D453/02 , C07D453/00
CPC分类号： C07D453/02 , A61P25/00 , C07D453/00
摘要： The present invention relates to novel geminal substituted aminobenzisoxazole compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
摘要翻译： 本发明涉及新的偕取代的氨基苯异恶唑化合物及其药物组合物，其适合作为α7-nAChR的激动剂或部分激动剂，以及制备这些化合物和组合物的方法，以及这些化合物和组合物在方法中的用途 维持，治疗和/或改善认知功能。 特别地，可以向有需要的患者，例如具有认知缺陷的患者和/或增强认知功能的愿望给予该化合物或组合物的方法，其可从中获益。
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