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公开(公告)号:US20230190816A1
公开(公告)日:2023-06-22
申请号:US17790597
申请日:2020-11-26
Inventor: Akihiko TAGUCHI , Yuko OGAWA , Yuka OKINAKA , Masanori FUKUSHIMA , Atsuo YAMANAKA
CPC classification number: A61K35/28 , A61P9/10 , A61P25/00 , A61K2035/124
Abstract: The effect of physical exercise performed on a physical function of a subject with an irreversibly reduced physical function is promoted. Bone marrow mononuclear cells, CD34-positive cells, CD133-positive cells, or stem cells are contained. The central and peripheral nerves communicate intimately with each other. When these cells are administered to a subject, and the subject performs an appropriate physical exercise, the reduced physical function can be dramatically improved. The physical exercise .is, for example, physical exercise that stimulates both of brain and peripheral nerves based on the interactive biofeedback theory. Thus, for example, when bone marrow mononuclear cells are administered to a patient with a sequela of cerebral infarction, and the patient performs an appropriate physical exercise, the effect of functional recovery from the sequela of the cerebral infarction is promoted.
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公开(公告)号:US20240299458A1
公开(公告)日:2024-09-12
申请号:US18575031
申请日:2022-06-30
Inventor: Akihiko TAGUCHI , Akie TAURA , Yuka OKINAKA , Yuko OGAWA , Takafumi KIMURA , Mitsunobu TANAKA , Kazuta YASUI , Akihiro FUCHIZAKI , Teruhito YASUI
IPC: A61K35/28 , A61P9/04 , A61P9/10 , C12N5/0789 , C12N13/00
CPC classification number: A61K35/28 , A61P9/04 , A61P9/10 , C12N5/0647 , C12N13/00
Abstract: The present invention relates to a pharmaceutical composition comprising a population of cells including irradiated hematopoietic stem cells, and a method for producing the pharmaceutical composition, specifically, a pharmaceutical composition for treating an ischemic disease, comprising a population of cells including irradiated hematopoietic stem cells, wherein the irradiation is irradiation at 50 Gy or less, and a method for producing the pharmaceutical composition.
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