公开(公告)号：US20120115808A1

公开(公告)日：2012-05-10

申请号：US13291294

申请日：2011-11-08

申请人： Francesco DELLA VALLE ,  Luciano De Petrocellis ,  Sabatino Maione ,  Vincenzo Di Marzo ,  Maria Federica Della Valle

发明人： Francesco DELLA VALLE ,  Luciano De Petrocellis ,  Sabatino Maione ,  Vincenzo Di Marzo ,  Maria Federica Della Valle

IPC分类号： A61K31/165 ,  A61K31/728 ,  A61P29/00 ,  A61K31/201

CPC分类号： A61K31/165 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0048 ,  A61K9/006 ,  A61K9/0095 ,  A61K9/06 ,  A61K9/7038 ,  A61K31/07 ,  A61K31/194 ,  A61K31/728 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to topical preparations containing N-palmitoyl-vanillamide having hyperalgesic activity. In particular, the invention relates to N-palmitoyl-vanillamide for use in the treatment of pathologies selected from: post-herpetic neuralgia, neuralgia of trigeminus, occipital neuralgia, dental neuralgia, glottopharyngeal neuralgia, uremic neuralgia, diabetic neuralgia, headache of different origin, neuropathic itch, neurogenic itch, uremic itch, vulvodinia, vulvar vestibulitis, ano-rectal pain and itch, balano-preputial pain and itch, painful urogenital disorders of dogs and cats, psoriasis-associated pruritus and pain, itching skin diseases (e.g. atopic dermatitis) in the human and veterinary field, muscular pain, pain of the tendon, osteoarthritis associated pain in humans, dogs and cats; painful eye diseases in the human and veterinary field, inflammatory pathologies of the oral cavity in the human and veterinary field.

摘要翻译： 本发明涉及具有过敏反应活性的N-棕榈酰 - 香草酰胺的局部制剂。 特别地，本发明涉及用于治疗选自以下的病理学的N-棕榈酰基 - 香草酰胺：疱疹后神经痛，三叉神经痛神经痛，枕骨神经痛，牙齿神经痛，咽喉神经痛，尿毒症神经痛，糖尿病性神经痛，不同来源的头痛 ，神经性瘙痒，神经源性瘙痒，尿毒症瘙痒，外阴阴道炎，外阴前庭炎，直肠疼痛和瘙痒，巴拉阴性疼痛和瘙痒，狗和猫的疼痛性泌尿生殖器疾病，牛皮癣相关性瘙痒和疼痛，瘙痒性皮肤病 人类和兽医领域的肌肉炎，肌肉疼痛，肌腱疼痛，人类，狗和猫中的骨关节炎相关疼痛; 人类和兽医领域的痛苦的眼睛疾病，人类和兽医领域的口腔炎症病理。

公开(公告)号：US08546352B2

公开(公告)日：2013-10-01

申请号：US13291294

申请日：2011-11-08

申请人： Francesco Della Valle ,  Luciano De Petrocellis ,  Sabatino Maione ,  Vincenzo Di Marzo ,  Maria Federica Della Valle

发明人： Francesco Della Valle ,  Luciano De Petrocellis ,  Sabatino Maione ,  Vincenzo Di Marzo ,  Maria Federica Della Valle

IPC分类号： A61K31/165

CPC分类号： A61K31/165 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0048 ,  A61K9/006 ,  A61K9/0095 ,  A61K9/06 ,  A61K9/7038 ,  A61K31/07 ,  A61K31/194 ,  A61K31/728 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to topical preparations containing N-palmitoyl-vanillamide having hyperalgesic activity. In particular, the invention relates to N-palmitoyl-vanillamide for use in the treatment of pathologies selected from: post-herpetic neuralgia, neuralgia of trigeminus, occipital neuralgia, dental neuralgia, glottopharyngeal neuralgia, uremic neuralgia, diabetic neuralgia, headache of different origin, neuropathic itch, neurogenic itch, uremic itch, vulvodinia, vulvar vestibulitis, ano-rectal pain and itch, balano-preputial pain and itch, painful urogenital disorders of dogs and cats, psoriasis-associated pruritus and pain, itching skin diseases (e.g. atopic dermatitis) in the human and veterinary field, muscular pain, pain of the tendon, osteoarthritis associated pain in humans, dogs and cats; painful eye diseases in the human and veterinary field, inflammatory pathologies of the oral cavity in the human and veterinary field.

摘要翻译： 本发明涉及具有过敏反应活性的N-棕榈酰 - 香草酰胺的局部制剂。 特别地，本发明涉及用于治疗选自以下的病理学的N-棕榈酰基 - 香草酰胺：疱疹后神经痛，三叉神经痛神经痛，枕骨神经痛，牙齿神经痛，咽喉神经痛，尿毒症神经痛，糖尿病性神经痛，不同来源的头痛 ，神经性瘙痒，神经源性瘙痒，尿毒症瘙痒，外阴阴道炎，外阴前庭炎，直肠疼痛和瘙痒，巴拉阴性疼痛和瘙痒，狗和猫的疼痛性泌尿生殖器疾病，牛皮癣相关性瘙痒和疼痛，瘙痒性皮肤病 人类和兽医领域的肌肉炎，肌肉疼痛，肌腱疼痛，人类，狗和猫中的骨关节炎相关疼痛; 人类和兽医领域的痛苦的眼睛疾病，人类和兽医领域的口腔炎症病理。

公开(公告)号：US09895342B2

公开(公告)日：2018-02-20

申请号：US14118563

申请日：2012-05-18

申请人： Sabatino Maione ,  Francesco Rossi ,  Geoffrey Guy ,  Colin Stott ,  Tetsuro Kikuchi

发明人： Sabatino Maione ,  Francesco Rossi ,  Geoffrey Guy ,  Colin Stott ,  Tetsuro Kikuchi

IPC分类号： A61K31/05 ,  A61K31/352

CPC分类号： A61K31/352 ,  A61K31/05

摘要： The present invention relates to cannabinoids for use in the treatment of neuropathic pain. Preferably the cannabinoids are one or more phytocannabinoids of: cannabigerol (CBG), cannabichromene (CBC), cannabidivarin (CBDV) or tetrahydrocannabivarin (THCV). More preferably the phytocannabinoids are isolated and/or purified from cannabis plant extracts.